Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384460003> ?p ?o ?g. }
- W4384460003 endingPage "108212" @default.
- W4384460003 startingPage "108212" @default.
- W4384460003 abstract "The last decade has witnessed great progress in the field of adoptive cell therapies, with the authorization of Kymriah (tisagenlecleucel) in 2017 by the Food and Drug Administration (FDA) as a crucial stepstone. Since then, five more CAR-T therapies have been approved for the treatment of hematological malignancies. While a great step forward to treating several types of blood cancers, CAR-T cell therapies are still associated with severe side-effect such as Graft-versus-Host Disease (GvHD), cytokine release syndrome (CRS) and neurotoxicity. Because of this, there has been continued interest in Natural Killer cells which avoid these side-effects while offering the possibility to generate allogeneic cell therapies. Similar to T-cells, NK cells can be genetically modified to improve their therapeutic efficacy in a variety of ways. In contrast to T cells, viral transduction of NK cells is remains inefficient and induces cytotoxic effects. Viral vectors also require a lengthy and expensive product development process and is accompanied by certain risks such as insertional mutagenesis. Therefore, non-viral transfection technologies are avidly being developed aimed at addressing these shortcomings of viral vectors. In this review we will present an overview of the potential of NK cells in cancer immunotherapies and the non-viral transfection technologies that have been explored to engineer them." @default.
- W4384460003 created "2023-07-16" @default.
- W4384460003 creator A5028407212 @default.
- W4384460003 creator A5033035322 @default.
- W4384460003 creator A5035116198 @default.
- W4384460003 creator A5056217966 @default.
- W4384460003 date "2023-11-01" @default.
- W4384460003 modified "2023-10-09" @default.
- W4384460003 title "Non-viral engineering of NK cells" @default.
- W4384460003 cites W1871540872 @default.
- W4384460003 cites W1954860593 @default.
- W4384460003 cites W1966156756 @default.
- W4384460003 cites W2004822121 @default.
- W4384460003 cites W2052605694 @default.
- W4384460003 cites W2070672521 @default.
- W4384460003 cites W2078519876 @default.
- W4384460003 cites W2087894311 @default.
- W4384460003 cites W2122459559 @default.
- W4384460003 cites W2145794545 @default.
- W4384460003 cites W2208560199 @default.
- W4384460003 cites W2319353123 @default.
- W4384460003 cites W2531550383 @default.
- W4384460003 cites W2554094503 @default.
- W4384460003 cites W2603369913 @default.
- W4384460003 cites W2749329560 @default.
- W4384460003 cites W2792523566 @default.
- W4384460003 cites W2794892435 @default.
- W4384460003 cites W2808166290 @default.
- W4384460003 cites W2885020841 @default.
- W4384460003 cites W2887418427 @default.
- W4384460003 cites W2898894410 @default.
- W4384460003 cites W2901575037 @default.
- W4384460003 cites W2952253205 @default.
- W4384460003 cites W2954372406 @default.
- W4384460003 cites W2965141141 @default.
- W4384460003 cites W2966747394 @default.
- W4384460003 cites W2967298159 @default.
- W4384460003 cites W2970667447 @default.
- W4384460003 cites W2974876532 @default.
- W4384460003 cites W2980981340 @default.
- W4384460003 cites W2999972782 @default.
- W4384460003 cites W3010399752 @default.
- W4384460003 cites W3016907174 @default.
- W4384460003 cites W3021671449 @default.
- W4384460003 cites W3024225839 @default.
- W4384460003 cites W3043781639 @default.
- W4384460003 cites W3080714131 @default.
- W4384460003 cites W3083908906 @default.
- W4384460003 cites W3113146435 @default.
- W4384460003 cites W3119901427 @default.
- W4384460003 cites W3121016072 @default.
- W4384460003 cites W3125249990 @default.
- W4384460003 cites W3134297015 @default.
- W4384460003 cites W3148101350 @default.
- W4384460003 cites W3157903242 @default.
- W4384460003 cites W3158278756 @default.
- W4384460003 cites W3158771720 @default.
- W4384460003 cites W3158980431 @default.
- W4384460003 cites W3169972885 @default.
- W4384460003 cites W3171571522 @default.
- W4384460003 cites W3188940990 @default.
- W4384460003 cites W3200265151 @default.
- W4384460003 cites W3208335437 @default.
- W4384460003 cites W3217808407 @default.
- W4384460003 cites W4223562536 @default.
- W4384460003 cites W4226098344 @default.
- W4384460003 cites W4255069196 @default.
- W4384460003 cites W4297977523 @default.
- W4384460003 doi "https://doi.org/10.1016/j.biotechadv.2023.108212" @default.
- W4384460003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37454745" @default.
- W4384460003 hasPublicationYear "2023" @default.
- W4384460003 type Work @default.
- W4384460003 citedByCount "0" @default.
- W4384460003 crossrefType "journal-article" @default.
- W4384460003 hasAuthorship W4384460003A5028407212 @default.
- W4384460003 hasAuthorship W4384460003A5033035322 @default.
- W4384460003 hasAuthorship W4384460003A5035116198 @default.
- W4384460003 hasAuthorship W4384460003A5056217966 @default.
- W4384460003 hasConcept C10882517 @default.
- W4384460003 hasConcept C154317977 @default.
- W4384460003 hasConcept C202751555 @default.
- W4384460003 hasConcept C203014093 @default.
- W4384460003 hasConcept C2777701055 @default.
- W4384460003 hasConcept C28328180 @default.
- W4384460003 hasConcept C3875195 @default.
- W4384460003 hasConcept C502942594 @default.
- W4384460003 hasConcept C54009773 @default.
- W4384460003 hasConcept C54355233 @default.
- W4384460003 hasConcept C55493867 @default.
- W4384460003 hasConcept C71924100 @default.
- W4384460003 hasConcept C81885089 @default.
- W4384460003 hasConcept C86803240 @default.
- W4384460003 hasConcept C8891405 @default.
- W4384460003 hasConcept C95444343 @default.
- W4384460003 hasConceptScore W4384460003C10882517 @default.
- W4384460003 hasConceptScore W4384460003C154317977 @default.
- W4384460003 hasConceptScore W4384460003C202751555 @default.
- W4384460003 hasConceptScore W4384460003C203014093 @default.