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• W4384460923 endingPage "104956" @default.
• W4384460923 startingPage "104956" @default.
• W4384460923 abstract "We investigated linkages among BCS prior to calving and placentome concentrations of metabolites, proteins in one‑carbon metabolism (OCM) and protein synthesis, and nutrient transport. Multiparous Holstein cows retrospectively divided by prepartal BCS at -4 weeks relative to parturition into high BCS (HBCS = 3.58 ± 0.23; n = 9) or normal BCS (NBCS = 3.02 ± 0.17; n = 13) were used. BCS was assessed using a 5-point scale (1 = thin, 5 = fat). Four placentomes per cow were collected at delivery and frozen in liquid N. Western blotting was used for protein abundance. Cystathionine-β-synthase (CBS) and betaine-homocysteine-S-methyltransferase (BHMT) activity were measured via 14C assays. Amino acids (AA) and metabolites in OCM were measured by liquid chromatography mass spectrometry (LC-MS). Compared with NBCS cows, the cellular stress sensor p-eIF2α was more than 2-fold greater (P = 0.04) in HBCS. Abundance of the AA-catabolism enzyme branched-chain α-ketoacid dehydrogenase complex was lower (P = 0.05) in HBCS cows. Although BHMT activity did not differ, greater concentration of betaine (P = 0.01) and lower (P = 0.05) concentration of dimethylglycine in HBCS cows suggested reduced flux through the methionine cycle. Despite a lack of difference in CBS activity, lower concentrations of cystathionine (P = 0.03) and hypotaurine (P = 0.04) along with lower cysteine and the tendency for lower total GSH (P = 0.10) in HBCS cows suggested a decrease in transsulfuration. Overall, associations between OCM in placentomes and BCS at calving exist. Identifying mechanisms responsible for these effects merits further research." @default.
• W4384460923 created "2023-07-16" @default.
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• W4384460923 date "2023-09-01" @default.
• W4384460923 modified "2023-10-15" @default.
• W4384460923 title "Body condition prepartum and its association with term placentome nutrient transporters, one‑carbon metabolism pathway activity, and intermediate metabolites in Holstein cows" @default.
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• W4384460923 doi "https://doi.org/10.1016/j.rvsc.2023.104956" @default.
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