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- W4384461285 abstract "The dynamics of infectious disease in a population critically involves both within-host pathogen replication and between host pathogen transmission. While modeling efforts have recently explored how within-host dynamics contribute to shaping population transmission, fewer have explored how ongoing circulation of an epidemic infectious disease can impact within-host immunological dynamics. We present a simple, influenza-inspired model that explores the potential for re-exposure during a single, ongoing outbreak to shape individual immune response and epidemiological potential in non-trivial ways. We show how even a simplified system can exhibit complex ongoing dynamics and sensitive thresholds in behavior. We also find epidemiological stochasticity likely plays a critical role in reinfection or in the maintenance of individual immunological protection over time." @default.
- W4384461285 created "2023-07-16" @default.
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- W4384461285 date "2023-09-01" @default.
- W4384461285 modified "2023-09-26" @default.
- W4384461285 title "An immuno-epidemiological model for transient immune protection: A case study for viral respiratory infections" @default.
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- W4384461285 doi "https://doi.org/10.1016/j.idm.2023.07.004" @default.
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