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• W4384470360 endingPage "115686" @default.
• W4384470360 startingPage "115686" @default.
• W4384470360 abstract "Cannabinoids are compounds found in the cannabis sativa plant. Cannabinoids, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), have potential therapeutic benefits in various medical conditions. Some can activate the cannabinoid receptors type-1 and -2 (CB1 and CB2), that are part of the endocannabinoid system (ECS), alongside the endocannabinoids and their metabolic enzymes. The ECS regulates physiological and cognitive processes and is a potential therapeutic target for a wide range of health conditions like chronic pain, anxiety, and neurodegenerative diseases. Synthetic cannabinoids, are associated with serious health risks, including addiction, psychosis, and death. Nonetheless, some of these molecules are also being explored for pharmacological applications. Angiogenesis is the process of forming new blood vessels from existing ones, crucial for growth, repair, and tissue maintenance. Dysregulation of this process is associated with several diseases, including cancer, diabetic retinopathy and reproductive pathologies, such as preeclampsia. Recent data suggests that cannabinoids may affect angiogenesis. Here, we reviewed their impact on pro-angiogenic factors, extracellular matrix enzymes and inhibitors, immune-inflammatory responses, angiogenic pathways and functional assays, focusing on the main compounds for each cannabinoid class: THC and CBD for phytocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG) for endocannabinoids and WIN-55, JWH-133, XLR-11, LYR-7 and LYR-8, for the synthetic cannabinoids. Despite conflicting reports about the actions of phytocannabinoids and endocannabinoids on angiogenesis, the ability to modulate the angiogenic process is undoubtedly confirmed. This may open a new therapeutical route for angiogenesis-related pathologies. In addition, synthetic cannabinoids present anti-angiogenic actions in several cell models, hinting their potential as anti-angiogenic drugs." @default.
• W4384470360 created "2023-07-17" @default.
• W4384470360 creator A5057712329 @default.
• W4384470360 creator A5066092179 @default.
• W4384470360 creator A5076327069 @default.
• W4384470360 creator A5090176261 @default.
• W4384470360 date "2023-09-01" @default.
• W4384470360 modified "2023-10-15" @default.
• W4384470360 title "Unveiling the angiogenic effects of cannabinoids: Enhancers or inhibitors?" @default.
• W4384470360 cites W1246635139 @default.
• W4384470360 cites W1527271824 @default.
• W4384470360 cites W1873396443 @default.
• W4384470360 cites W1940834207 @default.
• W4384470360 cites W1966414426 @default.
• W4384470360 cites W1973544026 @default.
• W4384470360 cites W1985859986 @default.
• W4384470360 cites W1989073099 @default.
• W4384470360 cites W1989737013 @default.
• W4384470360 cites W1992112921 @default.
• W4384470360 cites W1999023281 @default.
• W4384470360 cites W1999252121 @default.
• W4384470360 cites W2000292756 @default.
• W4384470360 cites W2002771508 @default.
• W4384470360 cites W2004220006 @default.
• W4384470360 cites W2009987061 @default.
• W4384470360 cites W2012641148 @default.
• W4384470360 cites W2018008610 @default.
• W4384470360 cites W2024653583 @default.
• W4384470360 cites W2026252047 @default.
• W4384470360 cites W2029775732 @default.
• W4384470360 cites W2036412371 @default.
• W4384470360 cites W2056188558 @default.
• W4384470360 cites W2075894678 @default.
• W4384470360 cites W2076415360 @default.
• W4384470360 cites W2077129920 @default.
• W4384470360 cites W2082886056 @default.
• W4384470360 cites W2083034715 @default.
• W4384470360 cites W2105293618 @default.
• W4384470360 cites W2106328972 @default.
• W4384470360 cites W2110458254 @default.
• W4384470360 cites W2117692326 @default.
• W4384470360 cites W2118629170 @default.
• W4384470360 cites W2120227293 @default.
• W4384470360 cites W2122435011 @default.
• W4384470360 cites W2123927868 @default.
• W4384470360 cites W2131008692 @default.
• W4384470360 cites W2131734586 @default.
• W4384470360 cites W2132860096 @default.
• W4384470360 cites W2138787512 @default.
• W4384470360 cites W2144229884 @default.
• W4384470360 cites W2144328304 @default.
• W4384470360 cites W2160291493 @default.
• W4384470360 cites W2160905168 @default.
• W4384470360 cites W2163087750 @default.
• W4384470360 cites W2163307816 @default.
• W4384470360 cites W2171275714 @default.
• W4384470360 cites W2198075473 @default.
• W4384470360 cites W2218595127 @default.
• W4384470360 cites W2317982666 @default.
• W4384470360 cites W2587553356 @default.
• W4384470360 cites W2621112208 @default.
• W4384470360 cites W2766734319 @default.
• W4384470360 cites W2782156109 @default.
• W4384470360 cites W2803607493 @default.
• W4384470360 cites W2809489644 @default.
• W4384470360 cites W2886046928 @default.
• W4384470360 cites W2899281139 @default.
• W4384470360 cites W2901552564 @default.
• W4384470360 cites W2983881420 @default.
• W4384470360 cites W2997891042 @default.
• W4384470360 cites W3036120527 @default.
• W4384470360 cites W3039099747 @default.
• W4384470360 cites W3082979654 @default.
• W4384470360 cites W3092463790 @default.
• W4384470360 cites W3094227856 @default.
• W4384470360 cites W3099132326 @default.
• W4384470360 cites W3117437033 @default.
• W4384470360 cites W3127619168 @default.
• W4384470360 cites W3148122758 @default.
• W4384470360 cites W3160646321 @default.
• W4384470360 cites W3183953302 @default.
• W4384470360 cites W3198987798 @default.
• W4384470360 cites W3200878533 @default.
• W4384470360 cites W3202684981 @default.
• W4384470360 cites W3205686052 @default.
• W4384470360 cites W3212070111 @default.
• W4384470360 cites W3213840032 @default.
• W4384470360 cites W3217573203 @default.
• W4384470360 cites W4200575060 @default.
• W4384470360 cites W4200607409 @default.
• W4384470360 cites W4211001418 @default.
• W4384470360 cites W4220800229 @default.
• W4384470360 cites W4224046478 @default.
• W4384470360 cites W4224212432 @default.
• W4384470360 cites W4224286201 @default.
• W4384470360 cites W4225813444 @default.
• W4384470360 cites W4226017576 @default.
• W4384470360 cites W4239769024 @default.

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