Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384492775> ?p ?o ?g. }
- W4384492775 endingPage "546" @default.
- W4384492775 startingPage "538" @default.
- W4384492775 abstract "MicroRNAs (miRNAs) and circulating cell-free mitochondrial DNA (ccf-mtDNA) have attracted interest as biological markers of affective disorders. In response to stress, it is known that miRNAs in mitochondria diffuse out of the cytoplasm alongside mtDNA; however, this process has not yet been identified. We hypothesized that miRNAs derived from specific cell nuclei cause mitochondrial damage and mtDNA fragmentation under MDD-associated stress conditions. A comprehensive analysis of the plasma miRNA levels and quantification of the plasma ccf-mtDNA copy number were performed in 69 patients with depression to determine correlations and identify genes and pathways interacting with miRNAs. The patients were randomly assigned to receive either selective serotonin reuptake inhibitors (SSRI) or mirtazapine. Their therapeutic efficacy over four weeks was evaluated in relation to miRNAs correlated with ccf-mtDNA copy number. The expression levels of the five miRNAs showed a significant positive correlation with the ccf-mtDNA copy number after correcting for multiple testing. These miRNAs are involved in gene expression related to thyroid hormone synthesis, the Hippo signaling pathway, vasopressin-regulated water reabsorption, and lysine degradation. Of these five miRNAs, miR-6068 and miR-4708-3p were significantly associated with the SSRI and mirtazapine treatment outcomes, respectively. This study did not show comparison with a healthy group. The expression levels of specific miRNAs were associated with ccf-mtDNA copy number in untreated depressed patients; moreover, these miRNAs were linked to antidepressant treatment outcomes. These findings are expected to lead to the elucidation of new pathological mechanism of depression." @default.
- W4384492775 created "2023-07-18" @default.
- W4384492775 creator A5009945280 @default.
- W4384492775 creator A5015711180 @default.
- W4384492775 creator A5019930073 @default.
- W4384492775 creator A5025981807 @default.
- W4384492775 creator A5032624282 @default.
- W4384492775 creator A5038401080 @default.
- W4384492775 creator A5048873795 @default.
- W4384492775 creator A5058118992 @default.
- W4384492775 creator A5066514910 @default.
- W4384492775 creator A5072854278 @default.
- W4384492775 creator A5076672133 @default.
- W4384492775 date "2023-10-01" @default.
- W4384492775 modified "2023-10-14" @default.
- W4384492775 title "Relationship between circulating mitochondrial DNA and microRNA in patients with major depression" @default.
- W4384492775 cites W1114871325 @default.
- W4384492775 cites W144423133 @default.
- W4384492775 cites W1514530409 @default.
- W4384492775 cites W1535419310 @default.
- W4384492775 cites W1967776532 @default.
- W4384492775 cites W1984120803 @default.
- W4384492775 cites W2012573908 @default.
- W4384492775 cites W2014205721 @default.
- W4384492775 cites W2029387743 @default.
- W4384492775 cites W2052922251 @default.
- W4384492775 cites W2061378977 @default.
- W4384492775 cites W2065527667 @default.
- W4384492775 cites W2065692954 @default.
- W4384492775 cites W2076693703 @default.
- W4384492775 cites W2092897692 @default.
- W4384492775 cites W2110684718 @default.
- W4384492775 cites W2112914821 @default.
- W4384492775 cites W2122742102 @default.
- W4384492775 cites W2148760296 @default.
- W4384492775 cites W2171672882 @default.
- W4384492775 cites W2191745121 @default.
- W4384492775 cites W2478017657 @default.
- W4384492775 cites W2509205468 @default.
- W4384492775 cites W2563086086 @default.
- W4384492775 cites W2585543838 @default.
- W4384492775 cites W2616216901 @default.
- W4384492775 cites W2624213438 @default.
- W4384492775 cites W2731022850 @default.
- W4384492775 cites W2780537000 @default.
- W4384492775 cites W2789855059 @default.
- W4384492775 cites W2791217032 @default.
- W4384492775 cites W2803941007 @default.
- W4384492775 cites W2896914467 @default.
- W4384492775 cites W2911679685 @default.
- W4384492775 cites W2944647162 @default.
- W4384492775 cites W3006535601 @default.
- W4384492775 cites W3012538260 @default.
- W4384492775 cites W3041491016 @default.
- W4384492775 cites W3091777431 @default.
- W4384492775 cites W3139250185 @default.
- W4384492775 cites W3170605229 @default.
- W4384492775 cites W3190680223 @default.
- W4384492775 cites W3210662747 @default.
- W4384492775 cites W4205900283 @default.
- W4384492775 cites W4220671154 @default.
- W4384492775 cites W4225773342 @default.
- W4384492775 cites W4234896620 @default.
- W4384492775 cites W4254455346 @default.
- W4384492775 cites W4318066558 @default.
- W4384492775 doi "https://doi.org/10.1016/j.jad.2023.07.073" @default.
- W4384492775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37467797" @default.
- W4384492775 hasPublicationYear "2023" @default.
- W4384492775 type Work @default.
- W4384492775 citedByCount "0" @default.
- W4384492775 crossrefType "journal-article" @default.
- W4384492775 hasAuthorship W4384492775A5009945280 @default.
- W4384492775 hasAuthorship W4384492775A5015711180 @default.
- W4384492775 hasAuthorship W4384492775A5019930073 @default.
- W4384492775 hasAuthorship W4384492775A5025981807 @default.
- W4384492775 hasAuthorship W4384492775A5032624282 @default.
- W4384492775 hasAuthorship W4384492775A5038401080 @default.
- W4384492775 hasAuthorship W4384492775A5048873795 @default.
- W4384492775 hasAuthorship W4384492775A5058118992 @default.
- W4384492775 hasAuthorship W4384492775A5066514910 @default.
- W4384492775 hasAuthorship W4384492775A5072854278 @default.
- W4384492775 hasAuthorship W4384492775A5076672133 @default.
- W4384492775 hasBestOaLocation W43844927751 @default.
- W4384492775 hasConcept C104317684 @default.
- W4384492775 hasConcept C126322002 @default.
- W4384492775 hasConcept C134018914 @default.
- W4384492775 hasConcept C145059251 @default.
- W4384492775 hasConcept C24586158 @default.
- W4384492775 hasConcept C2779177272 @default.
- W4384492775 hasConcept C2781068410 @default.
- W4384492775 hasConcept C2781161787 @default.
- W4384492775 hasConcept C54355233 @default.
- W4384492775 hasConcept C60644358 @default.
- W4384492775 hasConcept C71924100 @default.
- W4384492775 hasConcept C86803240 @default.
- W4384492775 hasConceptScore W4384492775C104317684 @default.
- W4384492775 hasConceptScore W4384492775C126322002 @default.
- W4384492775 hasConceptScore W4384492775C134018914 @default.