FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384492854> ?p ?o ?g. }

• W4384492854 abstract "Abstract At the center of the hippocampal tri-synaptic loop are synapses formed between mossy fiber (MF) terminals from granule cells in the dentate gyrus (DG) and proximal dendrites of CA3 pyramidal neurons. However, the molecular mechanism regulating the development and function of these synapses is poorly understood. In this study, we showed that neurotrophin-3 (NT3) was expressed in nearly all mature granule cells but not CA3 cells. We selectively deleted the NT3-encoding Ntf3 gene in the DG during the 1 st two postnatal weeks to generate a Ntf3 conditional knockout (Ntf3-cKO). Ntf3-cKO mice had normal hippocampal cytoarchitecture but displayed elevated anxiety level and impairments in contextual memory, spatial reference memory and nest building. As MF-CA3 synapses are essential for encoding of contextual memory, we examined synaptic transmission at these synapses using ex vivo electrophysiological recordings. We found that Ntf3-cKO mice showed impaired basal synaptic transmission due to deficits in excitatory postsynaptic currents mediated by AMPA receptors but normal presynaptic function and intrinsic excitability of CA3 pyramidal neurons. Consistent with this selective postsynaptic deficit, Ntf3-cKO mice had fewer and smaller thorny excrescences on proximal apical dendrites of CA3 neurons and lower GluR1 levels in the stratum lucidum area where MF-CA3 synapses reside but normal MF terminals, compared with control mice. Thus, our study indicates that NT3 expressed in the dentate gyrus is crucial for the postsynaptic structure and function of MF-CA3 synapses and hippocampal-dependent memory." @default.
• W4384492854 created "2023-07-18" @default.
• W4384492854 creator A5020421436 @default.
• W4384492854 creator A5035599351 @default.
• W4384492854 creator A5053643671 @default.
• W4384492854 creator A5053949053 @default.
• W4384492854 creator A5073135506 @default.
• W4384492854 date "2023-07-17" @default.
• W4384492854 modified "2023-10-16" @default.
• W4384492854 title "Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and contextual memory" @default.
• W4384492854 cites W1580685922 @default.
• W4384492854 cites W1867891474 @default.
• W4384492854 cites W1928590576 @default.
• W4384492854 cites W1963940970 @default.
• W4384492854 cites W1966734514 @default.
• W4384492854 cites W1967963204 @default.
• W4384492854 cites W1969692986 @default.
• W4384492854 cites W1969854375 @default.
• W4384492854 cites W1970720793 @default.
• W4384492854 cites W1971358085 @default.
• W4384492854 cites W1971776075 @default.
• W4384492854 cites W1996553105 @default.
• W4384492854 cites W2004552741 @default.
• W4384492854 cites W2012423618 @default.
• W4384492854 cites W2019969295 @default.
• W4384492854 cites W2023625164 @default.
• W4384492854 cites W2026717174 @default.
• W4384492854 cites W2027699509 @default.
• W4384492854 cites W2028346421 @default.
• W4384492854 cites W2029205914 @default.
• W4384492854 cites W2030563656 @default.
• W4384492854 cites W2036284062 @default.
• W4384492854 cites W2042754457 @default.
• W4384492854 cites W2043335534 @default.
• W4384492854 cites W2050032667 @default.
• W4384492854 cites W2064798254 @default.
• W4384492854 cites W2064963461 @default.
• W4384492854 cites W2070003250 @default.
• W4384492854 cites W2071358265 @default.
• W4384492854 cites W2072147769 @default.
• W4384492854 cites W2078686168 @default.
• W4384492854 cites W2078740239 @default.
• W4384492854 cites W2092284040 @default.
• W4384492854 cites W2093831527 @default.
• W4384492854 cites W2095391379 @default.
• W4384492854 cites W2104135721 @default.
• W4384492854 cites W2106179675 @default.
• W4384492854 cites W2112927743 @default.
• W4384492854 cites W2127810309 @default.
• W4384492854 cites W2128574573 @default.
• W4384492854 cites W2132506406 @default.
• W4384492854 cites W2139481908 @default.
• W4384492854 cites W2142686469 @default.
• W4384492854 cites W2150473092 @default.
• W4384492854 cites W2152541584 @default.
• W4384492854 cites W2157226283 @default.
• W4384492854 cites W2188820648 @default.
• W4384492854 cites W2207017804 @default.
• W4384492854 cites W2305686128 @default.
• W4384492854 cites W2410446460 @default.
• W4384492854 cites W2574596077 @default.
• W4384492854 cites W2787647862 @default.
• W4384492854 cites W2960829865 @default.
• W4384492854 cites W3014983981 @default.
• W4384492854 cites W3015724479 @default.
• W4384492854 cites W3154601095 @default.
• W4384492854 cites W3158834932 @default.
• W4384492854 doi "https://doi.org/10.1101/2023.07.16.549236" @default.
• W4384492854 hasPublicationYear "2023" @default.
• W4384492854 type Work @default.
• W4384492854 citedByCount "0" @default.
• W4384492854 crossrefType "posted-content" @default.
• W4384492854 hasAuthorship W4384492854A5020421436 @default.
• W4384492854 hasAuthorship W4384492854A5035599351 @default.
• W4384492854 hasAuthorship W4384492854A5053643671 @default.
• W4384492854 hasAuthorship W4384492854A5053949053 @default.
• W4384492854 hasAuthorship W4384492854A5073135506 @default.
• W4384492854 hasBestOaLocation W43844928541 @default.
• W4384492854 hasConcept C112592302 @default.
• W4384492854 hasConcept C148762608 @default.
• W4384492854 hasConcept C160268369 @default.
• W4384492854 hasConcept C169760540 @default.
• W4384492854 hasConcept C170493617 @default.
• W4384492854 hasConcept C17077164 @default.
• W4384492854 hasConcept C197341189 @default.
• W4384492854 hasConcept C200170125 @default.
• W4384492854 hasConcept C2776464000 @default.
• W4384492854 hasConcept C55493867 @default.
• W4384492854 hasConcept C61174792 @default.
• W4384492854 hasConcept C86803240 @default.
• W4384492854 hasConceptScore W4384492854C112592302 @default.
• W4384492854 hasConceptScore W4384492854C148762608 @default.
• W4384492854 hasConceptScore W4384492854C160268369 @default.
• W4384492854 hasConceptScore W4384492854C169760540 @default.
• W4384492854 hasConceptScore W4384492854C170493617 @default.
• W4384492854 hasConceptScore W4384492854C17077164 @default.
• W4384492854 hasConceptScore W4384492854C197341189 @default.
• W4384492854 hasConceptScore W4384492854C200170125 @default.
• W4384492854 hasConceptScore W4384492854C2776464000 @default.
• W4384492854 hasConceptScore W4384492854C55493867 @default.

• next