FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384493273> ?p ?o ?g. }

• W4384493273 endingPage "2126" @default.
• W4384493273 startingPage "2116" @default.
• W4384493273 abstract "Circ_0000376 could promote non-small cell lung cancer (NSCLC) progression; however, the role of circ_0000376 in paclitaxel (PTX) resistance of NSCLC is still unknown.Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot were applied for measuring circ_0000376, microRNA-1298-5p (miR-1298-5p), and karyopherin subunit alpha 4 (KPNA4) expression. The half inhibitory concentration (IC50) of PTX was assessed by cell counting kit-8 assay. 5-ethynyl-2'-deoxyuridine assay, wound healing assay, transwell assay, and flow cytometry were performed to measure the proliferation, migration, invasion, and apoptosis of cells. The regulatory mechanisms of circ_0000376, miR-1298-5p, and KPNA4 were validated by dual-luciferase reporter assay, RNA immunoprecipitation assay, and rescue experiments. Xenograft assay was used for the functional analysis of circ_0000376 in vivo.Circ_0000376 and KPNA4 expressions were upregulated, while miR-1298-5p expression was downregulated in PTX-resistant tissues and cells. Circ_0000376 depletion promoted PTX sensitivity and apoptosis, while suppressing the proliferation, migration, and invasion of PTX-resistant NSCLC cells. Furthermore, circ_0000376 could modulate KPNA4 expression by sponging miR-1298-5p. Rescue experiments showed that miR-1298-5p inhibition reversed the circ_0000376 depletion-mediated anticancer effects and PTX sensitivity. Moreover, miR-1298-5p inhibited PTX resistance and tumorigenesis of PTX-resistant cells, which were abolished by KPNA4 overexpression. In addition, circ_0000376 knockdown suppressed tumor growth and enhanced PTX sensitivity in vivo.Circ_0000376 facilitated PTX resistance and tumorigenesis of NSCLC by miR-1298-5p/KPNA4 axis, suggesting an underlying therapeutic strategy for NSCLC." @default.
• W4384493273 created "2023-07-18" @default.
• W4384493273 creator A5003019825 @default.
• W4384493273 creator A5047417325 @default.
• W4384493273 creator A5068325469 @default.
• W4384493273 creator A5072509956 @default.
• W4384493273 creator A5073570261 @default.
• W4384493273 date "2023-07-16" @default.
• W4384493273 modified "2023-09-27" @default.
• W4384493273 title "Circular <scp>RNA</scp> circ_0000376 promotes paclitaxel resistance and tumorigenesis of non‐small cell lung cancer via positively modulating <scp>KPNA4</scp> by sponging <scp>miR</scp>‐1298‐5p" @default.
• W4384493273 cites W2990601320 @default.
• W4384493273 cites W2999883676 @default.
• W4384493273 cites W3014312696 @default.
• W4384493273 cites W3031491161 @default.
• W4384493273 cites W3044106093 @default.
• W4384493273 cites W3080281062 @default.
• W4384493273 cites W3081062051 @default.
• W4384493273 cites W3097689927 @default.
• W4384493273 cites W3102889097 @default.
• W4384493273 cites W3104751490 @default.
• W4384493273 cites W3118261989 @default.
• W4384493273 cites W3118539953 @default.
• W4384493273 cites W3128641327 @default.
• W4384493273 cites W3131184953 @default.
• W4384493273 cites W3161282402 @default.
• W4384493273 cites W3177432860 @default.
• W4384493273 cites W3183401853 @default.
• W4384493273 cites W3184037783 @default.
• W4384493273 cites W3196241326 @default.
• W4384493273 cites W3196452118 @default.
• W4384493273 cites W3199945255 @default.
• W4384493273 cites W3203535862 @default.
• W4384493273 cites W4206427904 @default.
• W4384493273 cites W4206811227 @default.
• W4384493273 cites W4384493273 @default.
• W4384493273 doi "https://doi.org/10.1111/1759-7714.14994" @default.
• W4384493273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37455373" @default.
• W4384493273 hasPublicationYear "2023" @default.
• W4384493273 type Work @default.
• W4384493273 citedByCount "1" @default.
• W4384493273 countsByYear W43844932732023 @default.
• W4384493273 crossrefType "journal-article" @default.
• W4384493273 hasAuthorship W4384493273A5003019825 @default.
• W4384493273 hasAuthorship W4384493273A5047417325 @default.
• W4384493273 hasAuthorship W4384493273A5068325469 @default.
• W4384493273 hasAuthorship W4384493273A5072509956 @default.
• W4384493273 hasAuthorship W4384493273A5073570261 @default.
• W4384493273 hasBestOaLocation W43844932731 @default.
• W4384493273 hasConcept C104317684 @default.
• W4384493273 hasConcept C121608353 @default.
• W4384493273 hasConcept C127561419 @default.
• W4384493273 hasConcept C145059251 @default.
• W4384493273 hasConcept C153911025 @default.
• W4384493273 hasConcept C173396325 @default.
• W4384493273 hasConcept C190283241 @default.
• W4384493273 hasConcept C2777292972 @default.
• W4384493273 hasConcept C502942594 @default.
• W4384493273 hasConcept C54355233 @default.
• W4384493273 hasConcept C553184892 @default.
• W4384493273 hasConcept C55493867 @default.
• W4384493273 hasConcept C555283112 @default.
• W4384493273 hasConcept C62112901 @default.
• W4384493273 hasConcept C71924100 @default.
• W4384493273 hasConcept C86803240 @default.
• W4384493273 hasConceptScore W4384493273C104317684 @default.
• W4384493273 hasConceptScore W4384493273C121608353 @default.
• W4384493273 hasConceptScore W4384493273C127561419 @default.
• W4384493273 hasConceptScore W4384493273C145059251 @default.
• W4384493273 hasConceptScore W4384493273C153911025 @default.
• W4384493273 hasConceptScore W4384493273C173396325 @default.
• W4384493273 hasConceptScore W4384493273C190283241 @default.
• W4384493273 hasConceptScore W4384493273C2777292972 @default.
• W4384493273 hasConceptScore W4384493273C502942594 @default.
• W4384493273 hasConceptScore W4384493273C54355233 @default.
• W4384493273 hasConceptScore W4384493273C553184892 @default.
• W4384493273 hasConceptScore W4384493273C55493867 @default.
• W4384493273 hasConceptScore W4384493273C555283112 @default.
• W4384493273 hasConceptScore W4384493273C62112901 @default.
• W4384493273 hasConceptScore W4384493273C71924100 @default.
• W4384493273 hasConceptScore W4384493273C86803240 @default.
• W4384493273 hasIssue "22" @default.
• W4384493273 hasLocation W43844932731 @default.
• W4384493273 hasLocation W43844932732 @default.
• W4384493273 hasLocation W43844932733 @default.
• W4384493273 hasOpenAccess W4384493273 @default.
• W4384493273 hasPrimaryLocation W43844932731 @default.
• W4384493273 hasRelatedWork W1983015622 @default.
• W4384493273 hasRelatedWork W2033672302 @default.
• W4384493273 hasRelatedWork W2354760635 @default.
• W4384493273 hasRelatedWork W2494327966 @default.
• W4384493273 hasRelatedWork W2573992804 @default.
• W4384493273 hasRelatedWork W2765489800 @default.
• W4384493273 hasRelatedWork W3010357773 @default.
• W4384493273 hasRelatedWork W3206974297 @default.
• W4384493273 hasRelatedWork W4235347117 @default.
• W4384493273 hasRelatedWork W4282555464 @default.
• W4384493273 hasVolume "14" @default.
• W4384493273 isParatext "false" @default.

• next