Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384498339> ?p ?o ?g. }
- W4384498339 abstract "Hypoxia, low, non-physiological oxygen tension is a key regulator of tumor microenvironment, determining the pathological tumor vascularization. Alleviation of hypoxia through vessel normalization may be a promising therapeutic approach. We aimed to assess the role of low oxygen tension in PTEN-related pathways and proangiogenic response, in vitro, in two different tumor cell lines, focusing on potential therapeutic targets for tumor vessel normalization. Downregulation of PTEN in hypoxia mediates the activation of distinct mechanisms: cytoplasmic pAKT activation in melanoma and pMDM2 modulation in kidney cancer. We show that hypoxia-induced proangiogenic potential was stronger in Renca cells than B16 F10—confirmed by a distinct secretory potential and different ability to affect endothelial cells functions. Therefore, the impact of hypoxia on PTEN-mediated regulation may determine the therapeutic targets and effectiveness of vessel normalization and intrinsic characteristics of cancer cell have to be taken into account when designing treatment." @default.
- W4384498339 created "2023-07-18" @default.
- W4384498339 creator A5023025710 @default.
- W4384498339 creator A5077933847 @default.
- W4384498339 creator A5081419733 @default.
- W4384498339 creator A5087876704 @default.
- W4384498339 date "2023-07-17" @default.
- W4384498339 modified "2023-09-30" @default.
- W4384498339 title "Comparative analysis of the effect of hypoxia in two different tumor cell models shows the differential involvement of PTEN control of proangiogenic pathways" @default.
- W4384498339 cites W1520563745 @default.
- W4384498339 cites W1603230122 @default.
- W4384498339 cites W1921980522 @default.
- W4384498339 cites W1978139448 @default.
- W4384498339 cites W1978506033 @default.
- W4384498339 cites W1980013575 @default.
- W4384498339 cites W1981895579 @default.
- W4384498339 cites W1982085952 @default.
- W4384498339 cites W1999429023 @default.
- W4384498339 cites W2005964931 @default.
- W4384498339 cites W2010353217 @default.
- W4384498339 cites W2025036947 @default.
- W4384498339 cites W2027217537 @default.
- W4384498339 cites W2051023783 @default.
- W4384498339 cites W2055324254 @default.
- W4384498339 cites W2068912983 @default.
- W4384498339 cites W2074991531 @default.
- W4384498339 cites W2105385506 @default.
- W4384498339 cites W2115852392 @default.
- W4384498339 cites W2118263932 @default.
- W4384498339 cites W2126810504 @default.
- W4384498339 cites W2135838271 @default.
- W4384498339 cites W2136023563 @default.
- W4384498339 cites W2140088548 @default.
- W4384498339 cites W2143654068 @default.
- W4384498339 cites W2144101264 @default.
- W4384498339 cites W2152757414 @default.
- W4384498339 cites W2159283304 @default.
- W4384498339 cites W2170429710 @default.
- W4384498339 cites W2253213520 @default.
- W4384498339 cites W2337422219 @default.
- W4384498339 cites W2593850356 @default.
- W4384498339 cites W2732699482 @default.
- W4384498339 cites W2790339676 @default.
- W4384498339 cites W2810166643 @default.
- W4384498339 cites W2895088015 @default.
- W4384498339 cites W2903346602 @default.
- W4384498339 cites W2921552993 @default.
- W4384498339 cites W2949316146 @default.
- W4384498339 cites W2957053522 @default.
- W4384498339 cites W2975142399 @default.
- W4384498339 cites W2983881420 @default.
- W4384498339 cites W3015009229 @default.
- W4384498339 cites W3037575062 @default.
- W4384498339 cites W3130650015 @default.
- W4384498339 cites W3132176281 @default.
- W4384498339 cites W3138747175 @default.
- W4384498339 cites W4250428608 @default.
- W4384498339 cites W4280609960 @default.
- W4384498339 cites W4315754639 @default.
- W4384498339 cites W4322617808 @default.
- W4384498339 doi "https://doi.org/10.1139/bcb-2023-0047" @default.
- W4384498339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37459649" @default.
- W4384498339 hasPublicationYear "2023" @default.
- W4384498339 type Work @default.
- W4384498339 citedByCount "1" @default.
- W4384498339 countsByYear W43844983392023 @default.
- W4384498339 crossrefType "journal-article" @default.
- W4384498339 hasAuthorship W4384498339A5023025710 @default.
- W4384498339 hasAuthorship W4384498339A5077933847 @default.
- W4384498339 hasAuthorship W4384498339A5081419733 @default.
- W4384498339 hasAuthorship W4384498339A5087876704 @default.
- W4384498339 hasConcept C104317684 @default.
- W4384498339 hasConcept C126322002 @default.
- W4384498339 hasConcept C127561419 @default.
- W4384498339 hasConcept C178790620 @default.
- W4384498339 hasConcept C185592680 @default.
- W4384498339 hasConcept C2776107976 @default.
- W4384498339 hasConcept C2777609662 @default.
- W4384498339 hasConcept C2777658100 @default.
- W4384498339 hasConcept C2779081379 @default.
- W4384498339 hasConcept C2780394083 @default.
- W4384498339 hasConcept C2993207723 @default.
- W4384498339 hasConcept C3020616263 @default.
- W4384498339 hasConcept C502942594 @default.
- W4384498339 hasConcept C509974204 @default.
- W4384498339 hasConcept C540031477 @default.
- W4384498339 hasConcept C55493867 @default.
- W4384498339 hasConcept C62478195 @default.
- W4384498339 hasConcept C6929976 @default.
- W4384498339 hasConcept C71924100 @default.
- W4384498339 hasConcept C7836513 @default.
- W4384498339 hasConcept C86554907 @default.
- W4384498339 hasConcept C86803240 @default.
- W4384498339 hasConcept C95444343 @default.
- W4384498339 hasConceptScore W4384498339C104317684 @default.
- W4384498339 hasConceptScore W4384498339C126322002 @default.
- W4384498339 hasConceptScore W4384498339C127561419 @default.
- W4384498339 hasConceptScore W4384498339C178790620 @default.
- W4384498339 hasConceptScore W4384498339C185592680 @default.
- W4384498339 hasConceptScore W4384498339C2776107976 @default.