Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384498930> ?p ?o ?g. }
- W4384498930 abstract "Abstract Impaired autophagy promotes Inflammatory Bowel Disease (IBD). Claudin-2 is upregulated in IBD however its role in the pathobiology remains uncertain due to its complex regulation, including by autophagy. Irrespective, claudin-2 expression protects mice from DSS colitis. This study was undertaken to examine if an interplay between autophagy and claudin-2 protects from colitis and associated epithelial injury. Crypt culture and intestinal epithelial cells (IECs) are subjected to stress, including starvation or DSS, the chemical that induces colitis in-vivo. Autophagy flux, cell survival, co-immunoprecipitation, proximity ligation assay, and gene mutational studies are performed. These studies reveal that under colitis/stress conditions, claudin-2 undergoes polyubiquitination and P62/SQSTM1-assisted degradation through autophagy. Inhibiting autophagy-mediated claudin-2 degradation promotes cell death and thus suggest that claudin-2 degradation promotes autophagy flux to promote cell survival. Overall, these data inform for the previously undescribed role for claudin-2 in facilitating IECs survival under stress conditions, which can be harnessed for therapeutic advantages." @default.
- W4384498930 created "2023-07-18" @default.
- W4384498930 creator A5000721960 @default.
- W4384498930 creator A5004546135 @default.
- W4384498930 creator A5017668904 @default.
- W4384498930 creator A5020207133 @default.
- W4384498930 creator A5052717470 @default.
- W4384498930 creator A5064087099 @default.
- W4384498930 date "2023-07-17" @default.
- W4384498930 modified "2023-09-27" @default.
- W4384498930 title "P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium" @default.
- W4384498930 cites W1523693806 @default.
- W4384498930 cites W1541181512 @default.
- W4384498930 cites W1598865329 @default.
- W4384498930 cites W1829556225 @default.
- W4384498930 cites W1971896370 @default.
- W4384498930 cites W1972434272 @default.
- W4384498930 cites W1977683874 @default.
- W4384498930 cites W1982062616 @default.
- W4384498930 cites W1995042437 @default.
- W4384498930 cites W2002148098 @default.
- W4384498930 cites W2009455555 @default.
- W4384498930 cites W2011197968 @default.
- W4384498930 cites W2011606158 @default.
- W4384498930 cites W2013544053 @default.
- W4384498930 cites W2014918593 @default.
- W4384498930 cites W2018636808 @default.
- W4384498930 cites W2021178651 @default.
- W4384498930 cites W2021996063 @default.
- W4384498930 cites W2025321701 @default.
- W4384498930 cites W2030070767 @default.
- W4384498930 cites W2043775908 @default.
- W4384498930 cites W2047919822 @default.
- W4384498930 cites W2048030072 @default.
- W4384498930 cites W2055768068 @default.
- W4384498930 cites W2056164308 @default.
- W4384498930 cites W2057604945 @default.
- W4384498930 cites W2065031087 @default.
- W4384498930 cites W2071374729 @default.
- W4384498930 cites W2072904998 @default.
- W4384498930 cites W2075468859 @default.
- W4384498930 cites W2076588832 @default.
- W4384498930 cites W2082884465 @default.
- W4384498930 cites W2096853390 @default.
- W4384498930 cites W2099002508 @default.
- W4384498930 cites W2101203073 @default.
- W4384498930 cites W2105409495 @default.
- W4384498930 cites W2122031852 @default.
- W4384498930 cites W2148888894 @default.
- W4384498930 cites W2159449385 @default.
- W4384498930 cites W2166710590 @default.
- W4384498930 cites W2551865970 @default.
- W4384498930 cites W2561943186 @default.
- W4384498930 cites W2580420191 @default.
- W4384498930 cites W2620344213 @default.
- W4384498930 cites W2626087669 @default.
- W4384498930 cites W2743254891 @default.
- W4384498930 cites W2770083151 @default.
- W4384498930 cites W2792549532 @default.
- W4384498930 cites W2793011044 @default.
- W4384498930 cites W2795535470 @default.
- W4384498930 cites W2895041287 @default.
- W4384498930 cites W2902636128 @default.
- W4384498930 cites W2917451824 @default.
- W4384498930 cites W2917960454 @default.
- W4384498930 cites W2923738147 @default.
- W4384498930 cites W2943836085 @default.
- W4384498930 cites W2945386610 @default.
- W4384498930 cites W2958739722 @default.
- W4384498930 cites W3080892123 @default.
- W4384498930 cites W3120866366 @default.
- W4384498930 cites W3159203388 @default.
- W4384498930 cites W4200094286 @default.
- W4384498930 cites W4223969418 @default.
- W4384498930 cites W4378602689 @default.
- W4384498930 cites W841963364 @default.
- W4384498930 doi "https://doi.org/10.1038/s42003-023-05116-2" @default.
- W4384498930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37460613" @default.
- W4384498930 hasPublicationYear "2023" @default.
- W4384498930 type Work @default.
- W4384498930 citedByCount "1" @default.
- W4384498930 countsByYear W43844989302023 @default.
- W4384498930 crossrefType "journal-article" @default.
- W4384498930 hasAuthorship W4384498930A5000721960 @default.
- W4384498930 hasAuthorship W4384498930A5004546135 @default.
- W4384498930 hasAuthorship W4384498930A5017668904 @default.
- W4384498930 hasAuthorship W4384498930A5020207133 @default.
- W4384498930 hasAuthorship W4384498930A5052717470 @default.
- W4384498930 hasAuthorship W4384498930A5064087099 @default.
- W4384498930 hasBestOaLocation W43844989301 @default.
- W4384498930 hasConcept C104317684 @default.
- W4384498930 hasConcept C127561419 @default.
- W4384498930 hasConcept C134018914 @default.
- W4384498930 hasConcept C177779419 @default.
- W4384498930 hasConcept C185592680 @default.
- W4384498930 hasConcept C190283241 @default.
- W4384498930 hasConcept C203014093 @default.
- W4384498930 hasConcept C203522944 @default.
- W4384498930 hasConcept C25602115 @default.
- W4384498930 hasConcept C2775862500 @default.