FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384499247> ?p ?o ?g. }

• W4384499247 endingPage "1274" @default.
• W4384499247 startingPage "1263" @default.
• W4384499247 abstract "Abstract Thyroid hormones are essential during developmental myelination and may play a direct role in remyelination and repair in the adult central nervous system by promoting the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. Since tri-iodothyronine (T3) is believed to mediate the majority of important thyroid hormone actions, liothyronine (synthetic T3) has the potential to induce reparative mechanisms and limit neurodegeneration in multiple sclerosis (MS). We completed a phase 1b clinical trial to determine the safety and tolerability of ascending doses of liothyronine in individuals with relapsing and progressive MS. A total of 20 people with MS were enrolled in this single-center trial of oral liothyronine. Eighteen participants completed the 24-week study. Our study cohort included mostly women (11/20), majority relapsing MS (12/20), mean age of 46, and baseline median EDSS of 3.5. Liothyronine was tolerated well without treatment-related severe/serious adverse events or evidence of disease activation/clinical deterioration. The most common adverse events included gastrointestinal distress and abnormal thyroid function tests. No clinical thyrotoxicosis occurred. Importantly, we did not observe a negative impact on secondary clinical outcome measures. The CSF proteomic changes suggest a biological effect of T3 treatment within the CNS. We noted changes primarily in proteins associated with immune cell function and angiogenesis. Liothyronine appeared safe and was well tolerated in people with MS. A larger clinical trial will help assess whether liothyronine can promote oligodendrogenesis and enhance remyelination in vivo, limit axonal degeneration, or improve function." @default.
• W4384499247 created "2023-07-18" @default.
• W4384499247 creator A5010022210 @default.
• W4384499247 creator A5010284667 @default.
• W4384499247 creator A5019515700 @default.
• W4384499247 creator A5022243901 @default.
• W4384499247 creator A5023506438 @default.
• W4384499247 creator A5036301538 @default.
• W4384499247 creator A5044684613 @default.
• W4384499247 creator A5061851273 @default.
• W4384499247 creator A5062693491 @default.
• W4384499247 creator A5076230774 @default.
• W4384499247 creator A5080257392 @default.
• W4384499247 creator A5081367873 @default.
• W4384499247 date "2023-07-17" @default.
• W4384499247 modified "2023-10-14" @default.
• W4384499247 title "A Phase 1b, Open-Label Study to Evaluate the Safety and Tolerability of the Putative Remyelinating Agent, Liothyronine, in Individuals with MS" @default.
• W4384499247 cites W1501481090 @default.
• W4384499247 cites W1965505826 @default.
• W4384499247 cites W1970751485 @default.
• W4384499247 cites W1982603528 @default.
• W4384499247 cites W1998275001 @default.
• W4384499247 cites W2009162206 @default.
• W4384499247 cites W2014602172 @default.
• W4384499247 cites W2017820296 @default.
• W4384499247 cites W2022157317 @default.
• W4384499247 cites W2026877602 @default.
• W4384499247 cites W2028683480 @default.
• W4384499247 cites W2033638549 @default.
• W4384499247 cites W2036847119 @default.
• W4384499247 cites W2050713728 @default.
• W4384499247 cites W2056653636 @default.
• W4384499247 cites W2058358434 @default.
• W4384499247 cites W2070532347 @default.
• W4384499247 cites W2094409389 @default.
• W4384499247 cites W2098230394 @default.
• W4384499247 cites W2102033822 @default.
• W4384499247 cites W2106575819 @default.
• W4384499247 cites W2106769294 @default.
• W4384499247 cites W2136658595 @default.
• W4384499247 cites W2147134485 @default.
• W4384499247 cites W2150195459 @default.
• W4384499247 cites W2155055250 @default.
• W4384499247 cites W2155841310 @default.
• W4384499247 cites W2431082173 @default.
• W4384499247 cites W3006830647 @default.
• W4384499247 cites W3116007315 @default.
• W4384499247 cites W3121364493 @default.
• W4384499247 cites W4214939985 @default.
• W4384499247 doi "https://doi.org/10.1007/s13311-023-01402-3" @default.
• W4384499247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37460763" @default.
• W4384499247 hasPublicationYear "2023" @default.
• W4384499247 type Work @default.
• W4384499247 citedByCount "0" @default.
• W4384499247 crossrefType "journal-article" @default.
• W4384499247 hasAuthorship W4384499247A5010022210 @default.
• W4384499247 hasAuthorship W4384499247A5010284667 @default.
• W4384499247 hasAuthorship W4384499247A5019515700 @default.
• W4384499247 hasAuthorship W4384499247A5022243901 @default.
• W4384499247 hasAuthorship W4384499247A5023506438 @default.
• W4384499247 hasAuthorship W4384499247A5036301538 @default.
• W4384499247 hasAuthorship W4384499247A5044684613 @default.
• W4384499247 hasAuthorship W4384499247A5061851273 @default.
• W4384499247 hasAuthorship W4384499247A5062693491 @default.
• W4384499247 hasAuthorship W4384499247A5076230774 @default.
• W4384499247 hasAuthorship W4384499247A5080257392 @default.
• W4384499247 hasAuthorship W4384499247A5081367873 @default.
• W4384499247 hasBestOaLocation W43844992471 @default.
• W4384499247 hasConcept C126322002 @default.
• W4384499247 hasConcept C197934379 @default.
• W4384499247 hasConcept C203014093 @default.
• W4384499247 hasConcept C2777619251 @default.
• W4384499247 hasConcept C2778375690 @default.
• W4384499247 hasConcept C2778609137 @default.
• W4384499247 hasConcept C2780640218 @default.
• W4384499247 hasConcept C529278444 @default.
• W4384499247 hasConcept C71924100 @default.
• W4384499247 hasConceptScore W4384499247C126322002 @default.
• W4384499247 hasConceptScore W4384499247C197934379 @default.
• W4384499247 hasConceptScore W4384499247C203014093 @default.
• W4384499247 hasConceptScore W4384499247C2777619251 @default.
• W4384499247 hasConceptScore W4384499247C2778375690 @default.
• W4384499247 hasConceptScore W4384499247C2778609137 @default.
• W4384499247 hasConceptScore W4384499247C2780640218 @default.
• W4384499247 hasConceptScore W4384499247C529278444 @default.
• W4384499247 hasConceptScore W4384499247C71924100 @default.
• W4384499247 hasFunder F4320306161 @default.
• W4384499247 hasIssue "5" @default.
• W4384499247 hasLocation W43844992471 @default.
• W4384499247 hasLocation W43844992472 @default.
• W4384499247 hasOpenAccess W4384499247 @default.
• W4384499247 hasPrimaryLocation W43844992471 @default.
• W4384499247 hasRelatedWork W1968358500 @default.
• W4384499247 hasRelatedWork W2026159064 @default.
• W4384499247 hasRelatedWork W2044340152 @default.
• W4384499247 hasRelatedWork W2058358434 @default.
• W4384499247 hasRelatedWork W2243144343 @default.
• W4384499247 hasRelatedWork W2322717930 @default.

• next