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- W4384499319 endingPage "174" @default.
- W4384499319 startingPage "167" @default.
- W4384499319 abstract "Platelet mitochondrial dysfunction is both caused by, as well as a source of oxidative stress. Oxidative stress is a key hallmark of metabolic disorders such as dyslipidemia and diabetes, which are known to have higher risks for thrombotic complications.Increasing evidence supports a critical role for platelet mitochondria beyond energy production and apoptosis. Mitochondria are key regulators of reactive oxygen species and procoagulant platelets, which both contribute to pathological thrombosis. Studies targeting platelet mitochondrial pathways have reported promising results suggesting antithrombotic effects with limited impact on hemostasis in animal models.Targeting platelet mitochondria holds promise for the reduction of thrombotic complications in patients with metabolic disorders. Future studies should aim at validating these preclinical findings and translate them to the clinic." @default.
- W4384499319 created "2023-07-18" @default.
- W4384499319 creator A5020237271 @default.
- W4384499319 creator A5037659762 @default.
- W4384499319 creator A5091378889 @default.
- W4384499319 date "2023-07-17" @default.
- W4384499319 modified "2023-10-12" @default.
- W4384499319 title "Platelet mitochondria: the mighty few" @default.
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