Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384500529> ?p ?o ?g. }
- W4384500529 abstract "Abstract Despite recent advancements in cancer immunotherapy, challenges have yet to be surmounted to achieve two major goals of magnifying antitumor immunity and remodeling the immunosuppressive tumor microenvironment. Here, a nanosystem (ODM‐R) that integrates oxygen‐deficient molybdenum oxide (ODM) nanosonosensitizers and R7 peptides with tumor metabolism regulation effects is designed and fabricated for synergistic sonodynamic–immunometabolic therapy of spinal‐metastasized tumors. The ODM generates reactive oxygen species upon ultrasound irradiation to implement sonodynamic therapy (SDT), inducing cancer cell apoptosis and immunogenic cell death. The R7 attached on ODM markedly inhibits the uptake of glucose and excretion of lactic acid in cancer cells by perturbing the glycolysis process. The combination of SDT and tumor glycolysis obstruction by ODM‐R guarantees satisfactory efficacy in synergizing with PD‐L1 antibody to eradicate spinal‐metastasized tumors, achieving concurrent sonodynamic‐triggered immune activation and immunosuppressive tumor microenvironment remodeling. This work provides a proof‐of‐concept of nanosonosensitizers for boosting cancer immunotherapy by SDT and tumor metabolic regulation." @default.
- W4384500529 created "2023-07-18" @default.
- W4384500529 creator A5001631757 @default.
- W4384500529 creator A5004258040 @default.
- W4384500529 creator A5024493594 @default.
- W4384500529 creator A5026429110 @default.
- W4384500529 creator A5030749858 @default.
- W4384500529 creator A5037386990 @default.
- W4384500529 creator A5050140916 @default.
- W4384500529 creator A5075247746 @default.
- W4384500529 creator A5081262148 @default.
- W4384500529 date "2023-09-15" @default.
- W4384500529 modified "2023-10-17" @default.
- W4384500529 title "Peptide‐appended Nanosonosensitizers Targeting Tumor Glycolysis for Synergistic Sonodynamic‐Immunometabolic Therapy of Spinal‐Metastasized Tumor" @default.
- W4384500529 cites W1587050401 @default.
- W4384500529 cites W1914973957 @default.
- W4384500529 cites W2015207840 @default.
- W4384500529 cites W2044835625 @default.
- W4384500529 cites W2066671159 @default.
- W4384500529 cites W2067632426 @default.
- W4384500529 cites W2111524632 @default.
- W4384500529 cites W2117570650 @default.
- W4384500529 cites W2150123812 @default.
- W4384500529 cites W2257916459 @default.
- W4384500529 cites W2465658363 @default.
- W4384500529 cites W2533513686 @default.
- W4384500529 cites W2771639621 @default.
- W4384500529 cites W2810661705 @default.
- W4384500529 cites W2887239313 @default.
- W4384500529 cites W2890342126 @default.
- W4384500529 cites W2907564726 @default.
- W4384500529 cites W2924849767 @default.
- W4384500529 cites W2942224185 @default.
- W4384500529 cites W2942900492 @default.
- W4384500529 cites W2946392195 @default.
- W4384500529 cites W2953592429 @default.
- W4384500529 cites W2956997767 @default.
- W4384500529 cites W2986793362 @default.
- W4384500529 cites W3004414073 @default.
- W4384500529 cites W3012644262 @default.
- W4384500529 cites W3019242636 @default.
- W4384500529 cites W3028868129 @default.
- W4384500529 cites W3047618013 @default.
- W4384500529 cites W3100370737 @default.
- W4384500529 cites W3112874652 @default.
- W4384500529 cites W3134143734 @default.
- W4384500529 cites W3180220806 @default.
- W4384500529 cites W3181103086 @default.
- W4384500529 cites W3202827870 @default.
- W4384500529 cites W3205828230 @default.
- W4384500529 cites W3206546024 @default.
- W4384500529 cites W3208486179 @default.
- W4384500529 cites W3213992268 @default.
- W4384500529 cites W4200481514 @default.
- W4384500529 cites W4206911311 @default.
- W4384500529 cites W4210291515 @default.
- W4384500529 cites W4220988523 @default.
- W4384500529 cites W4225524746 @default.
- W4384500529 cites W4229332731 @default.
- W4384500529 cites W4231457728 @default.
- W4384500529 cites W4281737917 @default.
- W4384500529 cites W4283011418 @default.
- W4384500529 cites W4283123087 @default.
- W4384500529 cites W4285731139 @default.
- W4384500529 cites W4293546655 @default.
- W4384500529 cites W4295082414 @default.
- W4384500529 cites W4297459873 @default.
- W4384500529 cites W4301392719 @default.
- W4384500529 cites W4303946052 @default.
- W4384500529 cites W4310942340 @default.
- W4384500529 cites W4311769517 @default.
- W4384500529 cites W4313403193 @default.
- W4384500529 cites W4321457619 @default.
- W4384500529 cites W4323305871 @default.
- W4384500529 cites W4323347687 @default.
- W4384500529 cites W4365504131 @default.
- W4384500529 cites W4376848646 @default.
- W4384500529 doi "https://doi.org/10.1002/adma.202304246" @default.
- W4384500529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37460111" @default.
- W4384500529 hasPublicationYear "2023" @default.
- W4384500529 type Work @default.
- W4384500529 citedByCount "0" @default.
- W4384500529 crossrefType "journal-article" @default.
- W4384500529 hasAuthorship W4384500529A5001631757 @default.
- W4384500529 hasAuthorship W4384500529A5004258040 @default.
- W4384500529 hasAuthorship W4384500529A5024493594 @default.
- W4384500529 hasAuthorship W4384500529A5026429110 @default.
- W4384500529 hasAuthorship W4384500529A5030749858 @default.
- W4384500529 hasAuthorship W4384500529A5037386990 @default.
- W4384500529 hasAuthorship W4384500529A5050140916 @default.
- W4384500529 hasAuthorship W4384500529A5075247746 @default.
- W4384500529 hasAuthorship W4384500529A5081262148 @default.
- W4384500529 hasConcept C121608353 @default.
- W4384500529 hasConcept C126322002 @default.
- W4384500529 hasConcept C20251656 @default.
- W4384500529 hasConcept C203014093 @default.
- W4384500529 hasConcept C2776107976 @default.
- W4384500529 hasConcept C2777701055 @default.
- W4384500529 hasConcept C2778448707 @default.
- W4384500529 hasConcept C2779013556 @default.