FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384521669> ?p ?o ?g. }

• W4384521669 endingPage "e0288619" @default.
• W4384521669 startingPage "e0288619" @default.
• W4384521669 abstract "Introduction We describe transition of HIV-positive children from efavirenz- or nevirapine-based antiretroviral therapy (ART) to optimal dolutegravir (DTG) or lopinavir/ritonavir (LPV/r) (solid formulation)-based ART in Lesotho. Methods We followed a cohort of children less than 15 years of age who were initiated on ART on or after January 1, 2018 from 21 selected health facilities in Lesotho. From March 2020 to May 2022, we collected data retrospectively through chart abstraction and prospectively through caregiver interviews to cover a period of 24 months following treatment initiation. We used a structured questionnaire to collect data on demographics, ART regimen, drug formulations and switches, viral suppression, retention, and drug administration challenges. Data were summarized as frequencies and percentages, using SAS ver.9.4. Results Of 310 children enrolled in the study, 169 (54.5%) were female, and median age at ART initiation was 5.9 years (IQR 1.1–11.1). During follow-up, 19 (6.1%) children died, 41 (13.2%) were lost to follow-up and 74 (23.9%) transferred to non-study sites. At baseline, 144 (46.4%) children were receiving efavirenz-based ART regimen, 133 (42.9%) LPV/r, 27 (8.7%) DTG, 5 (1.6%) nevirapine; 1 child had incomplete records. By study end, 143 (46.1%) children were receiving LPV/r-based ART regimen, 109 (35.2%) DTG, and 58 (18.7%) were on efavirenz or nevirapine-based regimen. Of 116 children with viral load results after six months or more on a consistent regimen, viral suppression was seen in 35/53 (66.0%) children on LPV/r, 36/38 (94.7%) children on DTG and 19/24 (79.2%) children on efavirenz. Conclusion Following optimal ART introduction in Lesotho, most children in the cohort were transitioned and many attained or maintained viral suppression after transition; however, we recommend more robust viral load monitoring and patient tracking to reduce losses and improve outcomes after ART transition." @default.
• W4384521669 created "2023-07-18" @default.
• W4384521669 creator A5031205643 @default.
• W4384521669 creator A5032624737 @default.
• W4384521669 creator A5039621943 @default.
• W4384521669 creator A5065078027 @default.
• W4384521669 creator A5065526412 @default.
• W4384521669 creator A5067672049 @default.
• W4384521669 creator A5078884120 @default.
• W4384521669 date "2023-07-17" @default.
• W4384521669 modified "2023-10-16" @default.
• W4384521669 title "Optimizing antiretroviral therapy for children living with HIV: Experience from an observational cohort in Lesotho" @default.
• W4384521669 cites W1535394682 @default.
• W4384521669 cites W1865791593 @default.
• W4384521669 cites W1997148448 @default.
• W4384521669 cites W2002432974 @default.
• W4384521669 cites W2005274373 @default.
• W4384521669 cites W2162986610 @default.
• W4384521669 cites W2317258756 @default.
• W4384521669 cites W2344624438 @default.
• W4384521669 cites W2476161020 @default.
• W4384521669 cites W2526215611 @default.
• W4384521669 cites W2530271251 @default.
• W4384521669 cites W2562872029 @default.
• W4384521669 cites W2578556124 @default.
• W4384521669 cites W2595330763 @default.
• W4384521669 cites W2671862462 @default.
• W4384521669 cites W2762908497 @default.
• W4384521669 cites W2771047178 @default.
• W4384521669 cites W2904720540 @default.
• W4384521669 cites W2914830514 @default.
• W4384521669 cites W2936355118 @default.
• W4384521669 cites W2971781573 @default.
• W4384521669 cites W3031215372 @default.
• W4384521669 cites W3123963737 @default.
• W4384521669 cites W3131185266 @default.
• W4384521669 cites W3142355365 @default.
• W4384521669 cites W3159611925 @default.
• W4384521669 cites W4220673468 @default.
• W4384521669 cites W4226030902 @default.
• W4384521669 cites W4236479494 @default.
• W4384521669 cites W4288032966 @default.
• W4384521669 cites W4289527614 @default.
• W4384521669 doi "https://doi.org/10.1371/journal.pone.0288619" @default.
• W4384521669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37459349" @default.
• W4384521669 hasPublicationYear "2023" @default.
• W4384521669 type Work @default.
• W4384521669 citedByCount "0" @default.
• W4384521669 crossrefType "journal-article" @default.
• W4384521669 hasAuthorship W4384521669A5031205643 @default.
• W4384521669 hasAuthorship W4384521669A5032624737 @default.
• W4384521669 hasAuthorship W4384521669A5039621943 @default.
• W4384521669 hasAuthorship W4384521669A5065078027 @default.
• W4384521669 hasAuthorship W4384521669A5065526412 @default.
• W4384521669 hasAuthorship W4384521669A5067672049 @default.
• W4384521669 hasAuthorship W4384521669A5078884120 @default.
• W4384521669 hasBestOaLocation W43845216691 @default.
• W4384521669 hasConcept C126322002 @default.
• W4384521669 hasConcept C142462285 @default.
• W4384521669 hasConcept C187212893 @default.
• W4384521669 hasConcept C201903717 @default.
• W4384521669 hasConcept C203014093 @default.
• W4384521669 hasConcept C2777182164 @default.
• W4384521669 hasConcept C2779130552 @default.
• W4384521669 hasConcept C2779298103 @default.
• W4384521669 hasConcept C2779502633 @default.
• W4384521669 hasConcept C2781413609 @default.
• W4384521669 hasConcept C2781432083 @default.
• W4384521669 hasConcept C2993143319 @default.
• W4384521669 hasConcept C3013748606 @default.
• W4384521669 hasConcept C71924100 @default.
• W4384521669 hasConcept C72563966 @default.
• W4384521669 hasConceptScore W4384521669C126322002 @default.
• W4384521669 hasConceptScore W4384521669C142462285 @default.
• W4384521669 hasConceptScore W4384521669C187212893 @default.
• W4384521669 hasConceptScore W4384521669C201903717 @default.
• W4384521669 hasConceptScore W4384521669C203014093 @default.
• W4384521669 hasConceptScore W4384521669C2777182164 @default.
• W4384521669 hasConceptScore W4384521669C2779130552 @default.
• W4384521669 hasConceptScore W4384521669C2779298103 @default.
• W4384521669 hasConceptScore W4384521669C2779502633 @default.
• W4384521669 hasConceptScore W4384521669C2781413609 @default.
• W4384521669 hasConceptScore W4384521669C2781432083 @default.
• W4384521669 hasConceptScore W4384521669C2993143319 @default.
• W4384521669 hasConceptScore W4384521669C3013748606 @default.
• W4384521669 hasConceptScore W4384521669C71924100 @default.
• W4384521669 hasConceptScore W4384521669C72563966 @default.
• W4384521669 hasIssue "7" @default.
• W4384521669 hasLocation W43845216691 @default.
• W4384521669 hasLocation W43845216692 @default.
• W4384521669 hasOpenAccess W4384521669 @default.
• W4384521669 hasPrimaryLocation W43845216691 @default.
• W4384521669 hasRelatedWork W1939864032 @default.
• W4384521669 hasRelatedWork W2147344269 @default.
• W4384521669 hasRelatedWork W2943600197 @default.
• W4384521669 hasRelatedWork W3131635279 @default.
• W4384521669 hasRelatedWork W3214001157 @default.
• W4384521669 hasRelatedWork W4282827346 @default.

• next