FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384522013> ?p ?o ?g. }

• W4384522013 abstract "Abstract Tumor-associated macrophages (TAMs) are known to promote tumor growth, invasion, metastasis, and protumor angiogenesis, but the role of TAMs in the radiotherapy of esophagus cancer remains unclear. In this study, we first induced TAMs from human monocytes (THP-1) and identified using immunofluorescence and Western blotting assays. We then co-cultured them with human esophageal cancer cell lines. CCK-8, colony formation, Transwell, scratch test, and TUNEL assays showed that TAMs could promote proliferation, survival rate, invasion, migration, and radio-resistance and could inhibit apoptosis of the esophageal squamous carcinoma cell lines KYSE-150 and TE-1 before and after radiotherapy both in vivo and in vitro. Using LV-VEGFA-RNAi lentiviral vectors, we also found that TAMs could increase the expression of VEGFA and that inhibition of VEGFA could inhibit the biological function caused by TAMs. Finally, a Western blotting assay was used to evaluate the expression of various factors underlying the mechanism of TAMs. VEGFA, MAPK, P-MAPK, BCL-2, and Snail proteins were found to be overexpressed in co-cultured groups, whereas after VEGFA inhibition, MAPK, P-MAPK, BCL-2, and Snail proteins were found to be significantly down-regulated in the radiotherapy group. These study results offer important information regarding the mechanism of radio-resistance in esophageal cancer." @default.
• W4384522013 created "2023-07-18" @default.
• W4384522013 creator A5004217588 @default.
• W4384522013 creator A5010617667 @default.
• W4384522013 creator A5042404360 @default.
• W4384522013 creator A5048307621 @default.
• W4384522013 creator A5057145656 @default.
• W4384522013 creator A5059762791 @default.
• W4384522013 creator A5067086355 @default.
• W4384522013 creator A5068937883 @default.
• W4384522013 date "2023-07-17" @default.
• W4384522013 modified "2023-09-27" @default.
• W4384522013 title "The role of tumor-associated macrophages in the radioresistance of esophageal cancer cells via regulation of the VEGF-mediated angiogenic pathway" @default.
• W4384522013 cites W1994156742 @default.
• W4384522013 cites W2135708639 @default.
• W4384522013 cites W2141461155 @default.
• W4384522013 cites W2252711380 @default.
• W4384522013 cites W2513641194 @default.
• W4384522013 cites W2594615455 @default.
• W4384522013 cites W2609512644 @default.
• W4384522013 cites W2805059421 @default.
• W4384522013 cites W2806077739 @default.
• W4384522013 cites W2914634683 @default.
• W4384522013 cites W2946878207 @default.
• W4384522013 cites W2974291499 @default.
• W4384522013 cites W3011940221 @default.
• W4384522013 cites W3015467025 @default.
• W4384522013 cites W3042752065 @default.
• W4384522013 cites W3045321727 @default.
• W4384522013 cites W3087953356 @default.
• W4384522013 cites W3093826348 @default.
• W4384522013 cites W3128646645 @default.
• W4384522013 cites W3132016985 @default.
• W4384522013 cites W3173400583 @default.
• W4384522013 cites W4200068909 @default.
• W4384522013 cites W4213130038 @default.
• W4384522013 cites W4221011813 @default.
• W4384522013 cites W4283660545 @default.
• W4384522013 cites W4283714737 @default.
• W4384522013 cites W4296997699 @default.
• W4384522013 doi "https://doi.org/10.21203/rs.3.rs-3150709/v1" @default.
• W4384522013 hasPublicationYear "2023" @default.
• W4384522013 type Work @default.
• W4384522013 citedByCount "0" @default.
• W4384522013 crossrefType "posted-content" @default.
• W4384522013 hasAuthorship W4384522013A5004217588 @default.
• W4384522013 hasAuthorship W4384522013A5010617667 @default.
• W4384522013 hasAuthorship W4384522013A5042404360 @default.
• W4384522013 hasAuthorship W4384522013A5048307621 @default.
• W4384522013 hasAuthorship W4384522013A5057145656 @default.
• W4384522013 hasAuthorship W4384522013A5059762791 @default.
• W4384522013 hasAuthorship W4384522013A5067086355 @default.
• W4384522013 hasAuthorship W4384522013A5068937883 @default.
• W4384522013 hasBestOaLocation W43845220131 @default.
• W4384522013 hasConcept C121608353 @default.
• W4384522013 hasConcept C146285616 @default.
• W4384522013 hasConcept C167734588 @default.
• W4384522013 hasConcept C190283241 @default.
• W4384522013 hasConcept C2777025900 @default.
• W4384522013 hasConcept C2779013556 @default.
• W4384522013 hasConcept C2780394083 @default.
• W4384522013 hasConcept C502942594 @default.
• W4384522013 hasConcept C54355233 @default.
• W4384522013 hasConcept C55493867 @default.
• W4384522013 hasConcept C57074206 @default.
• W4384522013 hasConcept C58962609 @default.
• W4384522013 hasConcept C62112901 @default.
• W4384522013 hasConcept C62478195 @default.
• W4384522013 hasConcept C81885089 @default.
• W4384522013 hasConcept C86803240 @default.
• W4384522013 hasConcept C95444343 @default.
• W4384522013 hasConceptScore W4384522013C121608353 @default.
• W4384522013 hasConceptScore W4384522013C146285616 @default.
• W4384522013 hasConceptScore W4384522013C167734588 @default.
• W4384522013 hasConceptScore W4384522013C190283241 @default.
• W4384522013 hasConceptScore W4384522013C2777025900 @default.
• W4384522013 hasConceptScore W4384522013C2779013556 @default.
• W4384522013 hasConceptScore W4384522013C2780394083 @default.
• W4384522013 hasConceptScore W4384522013C502942594 @default.
• W4384522013 hasConceptScore W4384522013C54355233 @default.
• W4384522013 hasConceptScore W4384522013C55493867 @default.
• W4384522013 hasConceptScore W4384522013C57074206 @default.
• W4384522013 hasConceptScore W4384522013C58962609 @default.
• W4384522013 hasConceptScore W4384522013C62112901 @default.
• W4384522013 hasConceptScore W4384522013C62478195 @default.
• W4384522013 hasConceptScore W4384522013C81885089 @default.
• W4384522013 hasConceptScore W4384522013C86803240 @default.
• W4384522013 hasConceptScore W4384522013C95444343 @default.
• W4384522013 hasLocation W43845220131 @default.
• W4384522013 hasOpenAccess W4384522013 @default.
• W4384522013 hasPrimaryLocation W43845220131 @default.
• W4384522013 hasRelatedWork W1980070195 @default.
• W4384522013 hasRelatedWork W2049739326 @default.
• W4384522013 hasRelatedWork W2116227441 @default.
• W4384522013 hasRelatedWork W2164621617 @default.
• W4384522013 hasRelatedWork W2754385197 @default.
• W4384522013 hasRelatedWork W3149132115 @default.
• W4384522013 hasRelatedWork W3178515596 @default.
• W4384522013 hasRelatedWork W4236894028 @default.
• W4384522013 hasRelatedWork W4283771460 @default.

• next