FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384522130> ?p ?o ?g. }

• W4384522130 abstract "Abstract Background Because of high mutation rate, overrepresentation in genic regions, and link with various neurological, neurodegenerative, and movement disorders, GGC and GCC short tandem repeats (STRs) are prone to natural selection. Among a number of lacking data on those STRs, the 3-repeats of these STRs remain widely unexplored. Results In a genome-wide search in human, here we mapped GGC and GCC STRs of ≥ 3-repeats, and report islands of up to 45 of those STRs, populating spans of 1 to 2 kb of genomic DNA. RGPD4 and NOC4L harbored the densest (GGC)3 (probability 3.09061E-71) and (GCC)3 (probability 1.72376E-61) islands, respectively, and were human-specific. We also found prime instances of directional incremented density of STRs at a specific locus in human versus other species, including the FOXK2 and SKI GGC islands. The genes containing those islands significantly diverged in expression in human versus other species, and the proteins encoded by those genes interact closely in a physical interaction network, consequence of which may be human-specific characteristics such as higher order brain functions. Conclusion We report novel islands of GG C and GCC STRs of evolutionary relevance in human. The density, and in some instances, periodicity of these islands support them as a novel genomic entity, which need to be further explored in evolutionary, mechanistic, and functional platforms." @default.
• W4384522130 created "2023-07-18" @default.
• W4384522130 creator A5022514532 @default.
• W4384522130 creator A5028515672 @default.
• W4384522130 creator A5042797060 @default.
• W4384522130 creator A5046602267 @default.
• W4384522130 creator A5067344693 @default.
• W4384522130 creator A5069038046 @default.
• W4384522130 creator A5083282499 @default.
• W4384522130 date "2023-07-17" @default.
• W4384522130 modified "2023-09-27" @default.
• W4384522130 title "Novel islands of GGC and GCC repeats coincide with human evolution" @default.
• W4384522130 cites W1580242451 @default.
• W4384522130 cites W1721320694 @default.
• W4384522130 cites W1929249588 @default.
• W4384522130 cites W1980973068 @default.
• W4384522130 cites W1993864575 @default.
• W4384522130 cites W2000929500 @default.
• W4384522130 cites W2044110911 @default.
• W4384522130 cites W2045040686 @default.
• W4384522130 cites W2059920749 @default.
• W4384522130 cites W2071648302 @default.
• W4384522130 cites W2084748297 @default.
• W4384522130 cites W2094001311 @default.
• W4384522130 cites W2095907724 @default.
• W4384522130 cites W2107126732 @default.
• W4384522130 cites W2125042717 @default.
• W4384522130 cites W2140140672 @default.
• W4384522130 cites W2142877499 @default.
• W4384522130 cites W2765283293 @default.
• W4384522130 cites W2786119759 @default.
• W4384522130 cites W2912770510 @default.
• W4384522130 cites W2915072818 @default.
• W4384522130 cites W2949638707 @default.
• W4384522130 cites W2973583370 @default.
• W4384522130 cites W2976364525 @default.
• W4384522130 cites W2988655273 @default.
• W4384522130 cites W3033728751 @default.
• W4384522130 cites W3046118611 @default.
• W4384522130 cites W3122707914 @default.
• W4384522130 cites W3124195119 @default.
• W4384522130 cites W3164058565 @default.
• W4384522130 cites W3194226141 @default.
• W4384522130 cites W3205897064 @default.
• W4384522130 cites W3206008968 @default.
• W4384522130 cites W4205089832 @default.
• W4384522130 cites W4213272399 @default.
• W4384522130 cites W4288060543 @default.
• W4384522130 cites W4295700854 @default.
• W4384522130 cites W4308425295 @default.
• W4384522130 doi "https://doi.org/10.21203/rs.3.rs-3159062/v1" @default.
• W4384522130 hasPublicationYear "2023" @default.
• W4384522130 type Work @default.
• W4384522130 citedByCount "0" @default.
• W4384522130 crossrefType "posted-content" @default.
• W4384522130 hasAuthorship W4384522130A5022514532 @default.
• W4384522130 hasAuthorship W4384522130A5028515672 @default.
• W4384522130 hasAuthorship W4384522130A5042797060 @default.
• W4384522130 hasAuthorship W4384522130A5046602267 @default.
• W4384522130 hasAuthorship W4384522130A5067344693 @default.
• W4384522130 hasAuthorship W4384522130A5069038046 @default.
• W4384522130 hasAuthorship W4384522130A5083282499 @default.
• W4384522130 hasBestOaLocation W43845221301 @default.
• W4384522130 hasConcept C104317684 @default.
• W4384522130 hasConcept C141231307 @default.
• W4384522130 hasConcept C180754005 @default.
• W4384522130 hasConcept C197077220 @default.
• W4384522130 hasConcept C27149982 @default.
• W4384522130 hasConcept C2986302931 @default.
• W4384522130 hasConcept C54355233 @default.
• W4384522130 hasConcept C61320498 @default.
• W4384522130 hasConcept C70721500 @default.
• W4384522130 hasConcept C78458016 @default.
• W4384522130 hasConcept C84597430 @default.
• W4384522130 hasConcept C86803240 @default.
• W4384522130 hasConceptScore W4384522130C104317684 @default.
• W4384522130 hasConceptScore W4384522130C141231307 @default.
• W4384522130 hasConceptScore W4384522130C180754005 @default.
• W4384522130 hasConceptScore W4384522130C197077220 @default.
• W4384522130 hasConceptScore W4384522130C27149982 @default.
• W4384522130 hasConceptScore W4384522130C2986302931 @default.
• W4384522130 hasConceptScore W4384522130C54355233 @default.
• W4384522130 hasConceptScore W4384522130C61320498 @default.
• W4384522130 hasConceptScore W4384522130C70721500 @default.
• W4384522130 hasConceptScore W4384522130C78458016 @default.
• W4384522130 hasConceptScore W4384522130C84597430 @default.
• W4384522130 hasConceptScore W4384522130C86803240 @default.
• W4384522130 hasLocation W43845221301 @default.
• W4384522130 hasOpenAccess W4384522130 @default.
• W4384522130 hasPrimaryLocation W43845221301 @default.
• W4384522130 hasRelatedWork W1528307809 @default.
• W4384522130 hasRelatedWork W1986695036 @default.
• W4384522130 hasRelatedWork W2028087115 @default.
• W4384522130 hasRelatedWork W2059905092 @default.
• W4384522130 hasRelatedWork W2067757939 @default.
• W4384522130 hasRelatedWork W2105693258 @default.
• W4384522130 hasRelatedWork W2118062149 @default.
• W4384522130 hasRelatedWork W2121104507 @default.
• W4384522130 hasRelatedWork W2137445375 @default.
• W4384522130 hasRelatedWork W2152447148 @default.

• next