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• W4384522984 abstract "Abstract The present work demonstrates the biosynthesis of silver nanoparticles (AgNPs) using Coffea arabica (C. arabica) leaf extract. The AgNPs prepared by green route from C. arabica leaf were characterized through UV-Visible, X-ray diffraction (XRD), Transmission electron microscopy (TEM), and Energy dispersive electron spectroscopy (EDS). Later, the prepared NPs were conjugated with cysteamine-folic acid and utilized as a contrast medium for in vitro targeted imaging of folic acid receptor-expressing malignant cells by computerized tomography (CT). At 80 kVp, the targeted cells exhibited CT values which were two times greater than that of the non-targeted cells. The results were compared with the folic acid-negative cell lines as well as the effective inhibition of folic acid receptor using free folic acid substrate. The outcome of the study suggests that the fabricated cysteamine-folic acid conjugated silver nanoparticles (FA-Cys-AgNPs) could be utilized as a potential contrast agent for molecular CT imaging. This information can be taken into consideration for applying AgNPs in enhancing radiation dose where nanoparticles containing greater X-ray attenuation were applied." @default.
• W4384522984 created "2023-07-18" @default.
• W4384522984 creator A5039446355 @default.
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• W4384522984 date "2023-07-17" @default.
• W4384522984 modified "2023-09-27" @default.
• W4384522984 title "Fabrication of Folic acid-cysteamine modified AgNPs as promising contrast agent for CT imaging" @default.
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• W4384522984 doi "https://doi.org/10.21203/rs.3.rs-3160406/v1" @default.
• W4384522984 hasPublicationYear "2023" @default.
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