Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384557890> ?p ?o ?g. }
- W4384557890 endingPage "3636" @default.
- W4384557890 startingPage "3636" @default.
- W4384557890 abstract "Penile squamous cell carcinoma (PSCC) is a rare malignancy in most parts of the world and the underlying mechanisms of this disease have not been fully investigated. About 30-50% of cases are associated with high-risk human papillomavirus (HPV) infection, which may have prognostic value. When PSCC becomes resistant to upfront therapies there are limited options, thus further research is needed in this venue. The extracellular domain-facing protein profile on the cell surface (i.e., the surfaceome) is a key area for biomarker and drug target discovery. This research employs computational methods combined with cell line translatomic (n = 5) and RNA-seq transcriptomic data from patient-derived tumors (n = 18) to characterize the PSCC surfaceome, evaluate the composition dependency on HPV infection, and explore the prognostic impact of identified surfaceome candidates. Immunohistochemistry (IHC) was used to validate the localization of select surfaceome markers. This analysis characterized a diverse surfaceome within patient tumors with 25% and 18% of the surfaceome represented by the functional classes of receptors and transporters, respectively. Significant differences in protein classes were noted by HPV status, with the most change being seen in transporter proteins (25%). IHC confirmed the robust surface expression of select surfaceome targets in the top 85% of expression and a superfamily immunoglobulin protein called BSG/CD147 was prognostic of survival. This study provides the first description of the PSCC surfaceome and its relation to HPV infection and sets a foundation for novel biomarker and drug target discovery in this rare cancer." @default.
- W4384557890 created "2023-07-18" @default.
- W4384557890 creator A5010264712 @default.
- W4384557890 creator A5014154182 @default.
- W4384557890 creator A5015862974 @default.
- W4384557890 creator A5019394129 @default.
- W4384557890 creator A5019842974 @default.
- W4384557890 creator A5029857449 @default.
- W4384557890 creator A5031277780 @default.
- W4384557890 creator A5043881927 @default.
- W4384557890 creator A5052728390 @default.
- W4384557890 creator A5052753948 @default.
- W4384557890 creator A5059162411 @default.
- W4384557890 creator A5087467089 @default.
- W4384557890 date "2023-07-15" @default.
- W4384557890 modified "2023-09-25" @default.
- W4384557890 title "An Assessment of the Penile Squamous Cell Carcinoma Surfaceome for Biomarker and Therapeutic Target Discovery" @default.
- W4384557890 cites W1983457010 @default.
- W4384557890 cites W1985255881 @default.
- W4384557890 cites W1988156053 @default.
- W4384557890 cites W2036956828 @default.
- W4384557890 cites W2072470496 @default.
- W4384557890 cites W2081927805 @default.
- W4384557890 cites W2103525038 @default.
- W4384557890 cites W2108206279 @default.
- W4384557890 cites W2109972881 @default.
- W4384557890 cites W2124056645 @default.
- W4384557890 cites W2125482006 @default.
- W4384557890 cites W2139405623 @default.
- W4384557890 cites W2152458080 @default.
- W4384557890 cites W2179438025 @default.
- W4384557890 cites W2195440971 @default.
- W4384557890 cites W2197124664 @default.
- W4384557890 cites W2483772557 @default.
- W4384557890 cites W2514489125 @default.
- W4384557890 cites W2556877281 @default.
- W4384557890 cites W2565008393 @default.
- W4384557890 cites W2767891136 @default.
- W4384557890 cites W2883260705 @default.
- W4384557890 cites W2892768851 @default.
- W4384557890 cites W2895894818 @default.
- W4384557890 cites W2898873576 @default.
- W4384557890 cites W2904918604 @default.
- W4384557890 cites W2986109151 @default.
- W4384557890 cites W3011203123 @default.
- W4384557890 cites W3013786702 @default.
- W4384557890 cites W3043781639 @default.
- W4384557890 cites W3044145717 @default.
- W4384557890 cites W3094407181 @default.
- W4384557890 cites W3098769160 @default.
- W4384557890 cites W3101791484 @default.
- W4384557890 cites W3119841150 @default.
- W4384557890 cites W3122621164 @default.
- W4384557890 cites W3128485166 @default.
- W4384557890 cites W3129873548 @default.
- W4384557890 cites W3144573330 @default.
- W4384557890 cites W3153529541 @default.
- W4384557890 cites W3165143074 @default.
- W4384557890 cites W3179907307 @default.
- W4384557890 cites W3194281465 @default.
- W4384557890 cites W3195899163 @default.
- W4384557890 cites W3198254690 @default.
- W4384557890 cites W4200116291 @default.
- W4384557890 cites W4205456515 @default.
- W4384557890 cites W4211226255 @default.
- W4384557890 cites W4214566503 @default.
- W4384557890 cites W4230802851 @default.
- W4384557890 cites W4280590261 @default.
- W4384557890 cites W4283213838 @default.
- W4384557890 cites W4285728803 @default.
- W4384557890 cites W4286697597 @default.
- W4384557890 cites W4307428866 @default.
- W4384557890 cites W4310639017 @default.
- W4384557890 cites W4317568240 @default.
- W4384557890 cites W4321378920 @default.
- W4384557890 cites W4324046116 @default.
- W4384557890 cites W4324360079 @default.
- W4384557890 doi "https://doi.org/10.3390/cancers15143636" @default.
- W4384557890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37509297" @default.
- W4384557890 hasPublicationYear "2023" @default.
- W4384557890 type Work @default.
- W4384557890 citedByCount "0" @default.
- W4384557890 crossrefType "journal-article" @default.
- W4384557890 hasAuthorship W4384557890A5010264712 @default.
- W4384557890 hasAuthorship W4384557890A5014154182 @default.
- W4384557890 hasAuthorship W4384557890A5015862974 @default.
- W4384557890 hasAuthorship W4384557890A5019394129 @default.
- W4384557890 hasAuthorship W4384557890A5019842974 @default.
- W4384557890 hasAuthorship W4384557890A5029857449 @default.
- W4384557890 hasAuthorship W4384557890A5031277780 @default.
- W4384557890 hasAuthorship W4384557890A5043881927 @default.
- W4384557890 hasAuthorship W4384557890A5052728390 @default.
- W4384557890 hasAuthorship W4384557890A5052753948 @default.
- W4384557890 hasAuthorship W4384557890A5059162411 @default.
- W4384557890 hasAuthorship W4384557890A5087467089 @default.
- W4384557890 hasBestOaLocation W43845578901 @default.
- W4384557890 hasConcept C104317684 @default.
- W4384557890 hasConcept C124535831 @default.