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• W4384559624 abstract "The self-organization of embryonic stem cells (ESCs) into organized tissues with three distinct germ layers is critical to morphogenesis and early development. While the regulation of this self-organization by soluble signals is well established, the involvement of mechanical force gradients in this process remains unclear due to the lack of a suitable platform to study this process. In this study, we developed a 3D microenvironment to examine the influence of mechanical tension gradients on ESC-patterned differentiation during morphogenesis by controlling the geometrical signals (shape and size) of ESC colonies. We found that changes in colony geometry impacted the germ layer pattern, with Cdx2-positive cells being more abundant at edges and in areas with high curvatures. The differentiation patterns were determined by geometry-mediated cell tension gradients, with an extraembryonic mesoderm-like layer forming in high-tension regions and ectodermal-like lineages at low-tension regions in the center. Suppression of cytoskeletal tension hindered ESC self-organization. These results indicate that geometric confinement-mediated mechanical tension plays a crucial role in linking multicellular organization to cell differentiation and impacting tissue patterning." @default.
• W4384559624 created "2023-07-18" @default.
• W4384559624 creator A5087200876 @default.
• W4384559624 creator A5088450769 @default.
• W4384559624 date "2023-07-17" @default.
• W4384559624 modified "2023-09-27" @default.
• W4384559624 title "Geometric Confinement-Mediated Mechanical Tension Directs Patterned Differentiation of Mouse ESCs into Organized Germ Layers" @default.
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• W4384559624 doi "https://doi.org/10.1021/acsami.3c03798" @default.
• W4384559624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37458389" @default.
• W4384559624 hasPublicationYear "2023" @default.
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