Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384559892> ?p ?o ?g. }
- W4384559892 abstract "Abstract Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart failure and even death. Multiple biological processes, such as smooth muscle proliferation, endothelial dysfunction, inflammation, and resistance to apoptosis, are associated with PAH. Increasing evidence suggests that epigenetic factors play an important role in PAH by regulating the chromatin structure and altering the expression of critical genes. For example, aberrant DNA methylation and histone modifications such as histone acetylation and methylation have been observed in patients with PAH and are linked to vascular remodeling and pulmonary vascular dysfunction. In this review article, we provide a comprehensive overview of the role of key epigenetic targets in PAH pathogenesis, including DNA methyltransferase (DNMT), ten-eleven translocation enzymes (TET), switch-independent 3A (SIN3A), enhancer of zeste homolog 2 (EZH2), histone deacetylase (HDAC), and bromodomain-containing protein 4 (BRD4). Finally, we discuss the potential of multi-omics integration to better understand the molecular signature and profile of PAH patients and how this approach can help identify personalized treatment approaches." @default.
- W4384559892 created "2023-07-18" @default.
- W4384559892 creator A5015891213 @default.
- W4384559892 creator A5024831711 @default.
- W4384559892 creator A5069506427 @default.
- W4384559892 creator A5092486484 @default.
- W4384559892 date "2023-07-17" @default.
- W4384559892 modified "2023-10-14" @default.
- W4384559892 title "Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development" @default.
- W4384559892 cites W1019995178 @default.
- W4384559892 cites W1433720415 @default.
- W4384559892 cites W1643375850 @default.
- W4384559892 cites W1799342040 @default.
- W4384559892 cites W1932584694 @default.
- W4384559892 cites W1973962086 @default.
- W4384559892 cites W1975437957 @default.
- W4384559892 cites W1980269624 @default.
- W4384559892 cites W1997453048 @default.
- W4384559892 cites W2002919375 @default.
- W4384559892 cites W2005012250 @default.
- W4384559892 cites W2007701028 @default.
- W4384559892 cites W2011672901 @default.
- W4384559892 cites W2022627833 @default.
- W4384559892 cites W2032033480 @default.
- W4384559892 cites W2037586946 @default.
- W4384559892 cites W2040553259 @default.
- W4384559892 cites W2040875973 @default.
- W4384559892 cites W2046623240 @default.
- W4384559892 cites W2046812959 @default.
- W4384559892 cites W2047592317 @default.
- W4384559892 cites W206348675 @default.
- W4384559892 cites W2077898783 @default.
- W4384559892 cites W2080620002 @default.
- W4384559892 cites W2083669780 @default.
- W4384559892 cites W2084203180 @default.
- W4384559892 cites W2087141463 @default.
- W4384559892 cites W2092301324 @default.
- W4384559892 cites W2102616688 @default.
- W4384559892 cites W2104584146 @default.
- W4384559892 cites W2105349784 @default.
- W4384559892 cites W2106929712 @default.
- W4384559892 cites W2108664872 @default.
- W4384559892 cites W2109897362 @default.
- W4384559892 cites W2112137254 @default.
- W4384559892 cites W2114552998 @default.
- W4384559892 cites W2115147255 @default.
- W4384559892 cites W2117991391 @default.
- W4384559892 cites W2137354848 @default.
- W4384559892 cites W2141262339 @default.
- W4384559892 cites W2142745453 @default.
- W4384559892 cites W2145988292 @default.
- W4384559892 cites W2147524392 @default.
- W4384559892 cites W2157391786 @default.
- W4384559892 cites W2158364013 @default.
- W4384559892 cites W2158891637 @default.
- W4384559892 cites W2159974171 @default.
- W4384559892 cites W2161312917 @default.
- W4384559892 cites W2177368991 @default.
- W4384559892 cites W2209705351 @default.
- W4384559892 cites W2253353716 @default.
- W4384559892 cites W2264682687 @default.
- W4384559892 cites W2314837355 @default.
- W4384559892 cites W2336511463 @default.
- W4384559892 cites W2398761323 @default.
- W4384559892 cites W2403874820 @default.
- W4384559892 cites W2408851452 @default.
- W4384559892 cites W2488545743 @default.
- W4384559892 cites W2514258009 @default.
- W4384559892 cites W2519225277 @default.
- W4384559892 cites W2560116827 @default.
- W4384559892 cites W2591618758 @default.
- W4384559892 cites W2731206995 @default.
- W4384559892 cites W2748299478 @default.
- W4384559892 cites W2753382365 @default.
- W4384559892 cites W2755561004 @default.
- W4384559892 cites W2775301755 @default.
- W4384559892 cites W2792825729 @default.
- W4384559892 cites W2793237841 @default.
- W4384559892 cites W2799467557 @default.
- W4384559892 cites W2801818213 @default.
- W4384559892 cites W2802324910 @default.
- W4384559892 cites W2884498099 @default.
- W4384559892 cites W2888679364 @default.
- W4384559892 cites W2896159189 @default.
- W4384559892 cites W2896181585 @default.
- W4384559892 cites W2896361705 @default.
- W4384559892 cites W2899197098 @default.
- W4384559892 cites W2900679912 @default.
- W4384559892 cites W2901850087 @default.
- W4384559892 cites W2904180601 @default.
- W4384559892 cites W2904543538 @default.
- W4384559892 cites W2905582258 @default.
- W4384559892 cites W2936168604 @default.
- W4384559892 cites W2942931819 @default.
- W4384559892 cites W2943493790 @default.
- W4384559892 cites W2945044240 @default.
- W4384559892 cites W2953433221 @default.
- W4384559892 cites W2957271817 @default.
- W4384559892 cites W2964046229 @default.
- W4384559892 cites W2966867212 @default.