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- W4384560960 abstract "Synaptic heterogeneity is a hallmark of complex nervous systems that enables reliable and responsive communication in neural circuits. In this study, we investigated the contributions of voltage-gated calcium channels (VGCCs) to synaptic heterogeneity at two closely related Drosophila glutamatergic motor neurons, one low-and one high-Pr. We find that VGCC levels are highly predictive of heterogeneous release probability among individual active zones (AZs) of low-or high-Pr inputs, but not between neuronal subtypes. Underlying organizational differences in the AZ cytomatrix, VGCC composition, and a more compact arrangement of VGCCs alter the relationship between VGCC levels and Pr at AZs of low-vs. high-Pr inputs, explaining this apparent paradox. We further find that the CAST/ELKS AZ scaffolding protein Bruchpilot differentially regulates VGCC levels at low-and high-Pr AZs following acute glutamate receptor inhibition, indicating that synapse-specific organization also impacts adaptive plasticity. These findings reveal intersecting levels of molecular and spatial diversity with context-specific effects on heterogeneity in synaptic strength and plasticity." @default.
- W4384560960 created "2023-07-18" @default.
- W4384560960 creator A5026995692 @default.
- W4384560960 date "2023-07-17" @default.
- W4384560960 modified "2023-10-16" @default.
- W4384560960 title "eLife assessment: Molecular and organizational diversity intersect to generate functional synaptic heterogeneity within and between excitatory neuronal subtypes" @default.
- W4384560960 doi "https://doi.org/10.7554/elife.88412.1.sa0" @default.
- W4384560960 hasPublicationYear "2023" @default.
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