Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384561807> ?p ?o ?g. }
- W4384561807 endingPage "1351" @default.
- W4384561807 startingPage "1337" @default.
- W4384561807 abstract "One lead genetic risk signal of obesity-the rs1421085 T>C variant within the FTO gene-is reported to be functional in vitro but lacks evidence at an organism level. Here we recapitulate the homologous human variant in mice with global and brown adipocyte-specific variant knock-in and reveal that mice carrying the C-allele show increased brown fat thermogenic capacity and resistance to high-fat diet-induced adiposity, whereas the obesity-related phenotypic changes are blunted at thermoneutrality. Both in vivo and in vitro data reveal that the C-allele in brown adipocytes enhances the transcription of the Fto gene, which is associated with stronger chromatin looping linking the enhancer region and Fto promoter. Moreover, FTO knockdown or inhibition effectively eliminates the increased thermogenic ability of brown adipocytes carrying the C-allele. Taken together, these findings identify rs1421085 T>C as a functional variant promoting brown fat thermogenesis." @default.
- W4384561807 created "2023-07-18" @default.
- W4384561807 creator A5005476934 @default.
- W4384561807 creator A5010620513 @default.
- W4384561807 creator A5012777958 @default.
- W4384561807 creator A5027708049 @default.
- W4384561807 creator A5028894967 @default.
- W4384561807 creator A5036560647 @default.
- W4384561807 creator A5043253350 @default.
- W4384561807 creator A5046430973 @default.
- W4384561807 creator A5047157625 @default.
- W4384561807 creator A5052830821 @default.
- W4384561807 creator A5052886867 @default.
- W4384561807 creator A5053216181 @default.
- W4384561807 creator A5069370278 @default.
- W4384561807 creator A5069611208 @default.
- W4384561807 creator A5070461940 @default.
- W4384561807 creator A5079357621 @default.
- W4384561807 creator A5082585026 @default.
- W4384561807 creator A5087010578 @default.
- W4384561807 creator A5087372897 @default.
- W4384561807 date "2023-07-17" @default.
- W4384561807 modified "2023-10-17" @default.
- W4384561807 title "The rs1421085 variant within FTO promotes brown fat thermogenesis" @default.
- W4384561807 cites W1251807482 @default.
- W4384561807 cites W1636205509 @default.
- W4384561807 cites W1943020955 @default.
- W4384561807 cites W1965079305 @default.
- W4384561807 cites W1976844911 @default.
- W4384561807 cites W1976938970 @default.
- W4384561807 cites W1976966203 @default.
- W4384561807 cites W1979915761 @default.
- W4384561807 cites W1991838121 @default.
- W4384561807 cites W1996638990 @default.
- W4384561807 cites W1999623479 @default.
- W4384561807 cites W2002848248 @default.
- W4384561807 cites W2020157585 @default.
- W4384561807 cites W2028335133 @default.
- W4384561807 cites W2034126438 @default.
- W4384561807 cites W2039153962 @default.
- W4384561807 cites W2040964350 @default.
- W4384561807 cites W2045435533 @default.
- W4384561807 cites W2047402752 @default.
- W4384561807 cites W2048002474 @default.
- W4384561807 cites W2053415882 @default.
- W4384561807 cites W2054804828 @default.
- W4384561807 cites W2056631165 @default.
- W4384561807 cites W2063020711 @default.
- W4384561807 cites W2064695336 @default.
- W4384561807 cites W2070800705 @default.
- W4384561807 cites W2079171740 @default.
- W4384561807 cites W2091141973 @default.
- W4384561807 cites W2092207134 @default.
- W4384561807 cites W2093071388 @default.
- W4384561807 cites W2097660065 @default.
- W4384561807 cites W2098583905 @default.
- W4384561807 cites W2099373794 @default.
- W4384561807 cites W2100934963 @default.
- W4384561807 cites W2108303181 @default.
- W4384561807 cites W2110456510 @default.
- W4384561807 cites W2128865541 @default.
- W4384561807 cites W2132358997 @default.
- W4384561807 cites W2138073275 @default.
- W4384561807 cites W2138783639 @default.
- W4384561807 cites W2148400263 @default.
- W4384561807 cites W2156714600 @default.
- W4384561807 cites W2158069164 @default.
- W4384561807 cites W2169648564 @default.
- W4384561807 cites W2219944656 @default.
- W4384561807 cites W2409729650 @default.
- W4384561807 cites W2414345279 @default.
- W4384561807 cites W2512007813 @default.
- W4384561807 cites W2612961779 @default.
- W4384561807 cites W2754165550 @default.
- W4384561807 cites W2772792536 @default.
- W4384561807 cites W2780943351 @default.
- W4384561807 cites W2789858140 @default.
- W4384561807 cites W2792532657 @default.
- W4384561807 cites W2793768356 @default.
- W4384561807 cites W2800258284 @default.
- W4384561807 cites W2935701257 @default.
- W4384561807 cites W2940805049 @default.
- W4384561807 cites W2952883732 @default.
- W4384561807 cites W2968498415 @default.
- W4384561807 cites W2999336198 @default.
- W4384561807 cites W2999574254 @default.
- W4384561807 cites W3004490498 @default.
- W4384561807 cites W3082268778 @default.
- W4384561807 cites W3131597949 @default.
- W4384561807 cites W3134939688 @default.
- W4384561807 cites W3137102179 @default.
- W4384561807 cites W3158393751 @default.
- W4384561807 cites W3164090582 @default.
- W4384561807 cites W3185232353 @default.
- W4384561807 cites W3193389306 @default.
- W4384561807 cites W4319656575 @default.
- W4384561807 doi "https://doi.org/10.1038/s42255-023-00847-2" @default.
- W4384561807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37460841" @default.