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• W4384562666 endingPage "110828" @default.
• W4384562666 startingPage "110828" @default.
• W4384562666 abstract "The gut microbiome plays a significant role in methamphetamine addiction. Previous studies using short-read amplicon sequencing have described alterations in microbiota at the genus level and predicted function, in which taxonomic resolution is insufficient for accurate functional measurements. To address this limitation, we employed metagenome sequencing to intuitively associate species to functions of gut microbiota in methamphetamine-induced conditioned place preference. We observed differential perturbations of species-level functional profiling of the gut microbiota across phases of METH-induced CPP, with alterations in SCFA metabolism and bacterial motility at the acquisition phase and substance dependence-alcoholism pathway and amino acid metabolism at the extinction phase. Our findings suggest that reduced beneficial bacteria, i.e., Lactobacillus reuteri, contributed to the alteration of SCFA metabolism, while the increased abundance of Akkermansia muciniphila during the extinction phase may be associated with altered phenylalanine, tyrosine, and tryptophan metabolism and substance dependence pathway. Our study further supports the association between specific microbial taxa and METH-induced rewarding." @default.
• W4384562666 created "2023-07-18" @default.
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• W4384562666 date "2023-12-01" @default.
• W4384562666 modified "2023-10-01" @default.
• W4384562666 title "Unraveling the differential perturbations of species-level functional profiling of gut microbiota among phases of methamphetamine-induced conditioned place preference" @default.
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• W4384562666 doi "https://doi.org/10.1016/j.pnpbp.2023.110828" @default.
• W4384562666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37459963" @default.
• W4384562666 hasPublicationYear "2023" @default.
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