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• W4384563225 endingPage "102024" @default.
• W4384563225 startingPage "102024" @default.
• W4384563225 abstract "Monkeypox virus (Mpox) is a zoonotic infectious disease that threatens human and animal health, with a global outbreak of the low-pathogenic Mpox beginning from 2022. In this study, we analyzed the codon usage of Mpox between two clades, Clade-I and Clade-IIb-B, to understand changes in host adaptation. Clade-IIb-B of the Mpox genome underwent non-adaptive evolution making it less adapted to its host than Clade-I. The analysis of individual genes revealed that 48 genes exhibited non-adaptive mutation, while 38 genes underwent adaptive mutations. Genes involved in replication, transcription, and host-modulation exhibited a mix of adaptive and non-adaptive evolutionary patterns. This study also found that the mutations of Mpox led to changes in non-adaptative genes in different organs. Additionally, we found that codon usage of Mpox was less similar to that of up-regulated host genes and more similar to that of down-regulated host genes post-infection, indicating that codon usage affects host gene expression. Overall, the study highlights the non-adaptive changes in codon usage as a potential cause of differences in Mpox virulence and provides insights into the evolutionary and adaptive mechanisms of Mpox and its potential impact on pathogenicity and host adaptation." @default.
• W4384563225 created "2023-07-18" @default.
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• W4384563225 date "2023-09-01" @default.
• W4384563225 modified "2023-10-18" @default.
• W4384563225 title "Non-adaptive evolution in codon usage of human-origin monkeypox virus" @default.
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• W4384563225 doi "https://doi.org/10.1016/j.cimid.2023.102024" @default.
• W4384563225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37487313" @default.
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