Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384563425> ?p ?o ?g. }
- W4384563425 endingPage "166805" @default.
- W4384563425 startingPage "166805" @default.
- W4384563425 abstract "Neoatherosclerosis (NA), the main pathological basis of late stent failure, is the main limitation of interventional therapy. However, the specific pathogenesis and treatment remain unclear. In vivo, NA model was established by carotid wire injury and high-fat feeding in ApoE−/− mice. Oxidized low-density lipoprotein receptor-1/lectin-like oxidized low-density lipoprotein receptor-1 (OLR1/LOX-1), a specific receptor for oxidized low-density lipoprotein (ox-LDL), was specifically ectopically overexpressed in hepatocytes by portal vein injection of adeno-associated serotype 8 (AAV8)-thyroid binding globulin (TBG)-Olr1 and the protective effect against NA was examined. In vitro, LOX-1 was overexpressed on HHL5 using lentivirus (LV)-OLR1 and the vascular smooth muscle cells (VSMCs)-HHL5 indirect co-culture system was established to examine its protective effect on VSMCs and the molecular mechanism. Functionally, we found that specific ectopic overexpression of LOX-1 by hepatocytes competitively engulfed and metabolized ox-LDL, alleviating its resulting phenotypic transformation of VSMCs including migration, downregulation of contractile shape markers (smooth muscle α-actin (SMαA) and smooth muscle-22α (SM22α)), and upregulation of proliferative/migratory shape markers (osteopontin (OPN) and Vimentin) as well as foaminess and apoptosis, thereby alleviating NA, which independent of low-density lipoprotein (LDL) lowering treatment (evolocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9)). Mechanistically, we found that overexpression of LOX-1 in hepatocytes competitively engulfed and metabolized ox-LDL through upregulation of arachidonate-15-lipoxygenase (ALOX15), which further upregulated scavenger receptor class B type I (SRBI) and ATP-binding cassette transporter A1 (ABCA1). In conclusion, the overexpression of LOX-1 in liver protects VSMCs from phenotypic transformation and wire injury induced carotid neoatherosclerosis through ALOX15." @default.
- W4384563425 created "2023-07-18" @default.
- W4384563425 creator A5001831218 @default.
- W4384563425 creator A5018411567 @default.
- W4384563425 creator A5033351939 @default.
- W4384563425 creator A5057610054 @default.
- W4384563425 creator A5069108050 @default.
- W4384563425 date "2023-12-01" @default.
- W4384563425 modified "2023-10-17" @default.
- W4384563425 title "Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15" @default.
- W4384563425 cites W1527614413 @default.
- W4384563425 cites W1861368551 @default.
- W4384563425 cites W1973243569 @default.
- W4384563425 cites W1979717214 @default.
- W4384563425 cites W1993222177 @default.
- W4384563425 cites W1995663832 @default.
- W4384563425 cites W2001222940 @default.
- W4384563425 cites W2002585927 @default.
- W4384563425 cites W2014193449 @default.
- W4384563425 cites W2018226841 @default.
- W4384563425 cites W2018911114 @default.
- W4384563425 cites W2021422705 @default.
- W4384563425 cites W2029200573 @default.
- W4384563425 cites W2030757537 @default.
- W4384563425 cites W2043080029 @default.
- W4384563425 cites W2043858356 @default.
- W4384563425 cites W2048300090 @default.
- W4384563425 cites W2049647259 @default.
- W4384563425 cites W2068829315 @default.
- W4384563425 cites W2074102438 @default.
- W4384563425 cites W2080883999 @default.
- W4384563425 cites W2083907156 @default.
- W4384563425 cites W2091246594 @default.
- W4384563425 cites W2101624540 @default.
- W4384563425 cites W2107233004 @default.
- W4384563425 cites W2112645925 @default.
- W4384563425 cites W2121881445 @default.
- W4384563425 cites W2139678977 @default.
- W4384563425 cites W2147918847 @default.
- W4384563425 cites W2149254606 @default.
- W4384563425 cites W2153647382 @default.
- W4384563425 cites W2155677898 @default.
- W4384563425 cites W2157157967 @default.
- W4384563425 cites W2157460962 @default.
- W4384563425 cites W2160204754 @default.
- W4384563425 cites W2168042733 @default.
- W4384563425 cites W2168175864 @default.
- W4384563425 cites W2197006860 @default.
- W4384563425 cites W2236488484 @default.
- W4384563425 cites W2272435313 @default.
- W4384563425 cites W2336178357 @default.
- W4384563425 cites W2402331083 @default.
- W4384563425 cites W2479004574 @default.
- W4384563425 cites W2488076079 @default.
- W4384563425 cites W2588820306 @default.
- W4384563425 cites W2592614291 @default.
- W4384563425 cites W2611410760 @default.
- W4384563425 cites W2620025187 @default.
- W4384563425 cites W2620254432 @default.
- W4384563425 cites W2739961756 @default.
- W4384563425 cites W2765145329 @default.
- W4384563425 cites W2770104862 @default.
- W4384563425 cites W2913862831 @default.
- W4384563425 cites W2925599397 @default.
- W4384563425 cites W2961458196 @default.
- W4384563425 cites W2979546032 @default.
- W4384563425 cites W2981278341 @default.
- W4384563425 cites W2989685742 @default.
- W4384563425 cites W2999535131 @default.
- W4384563425 cites W3022864527 @default.
- W4384563425 cites W3097362727 @default.
- W4384563425 cites W3124342352 @default.
- W4384563425 cites W3173321900 @default.
- W4384563425 cites W3211493750 @default.
- W4384563425 cites W4200250462 @default.
- W4384563425 cites W4214872977 @default.
- W4384563425 cites W4220713086 @default.
- W4384563425 cites W4220779730 @default.
- W4384563425 doi "https://doi.org/10.1016/j.bbadis.2023.166805" @default.
- W4384563425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37468019" @default.
- W4384563425 hasPublicationYear "2023" @default.
- W4384563425 type Work @default.
- W4384563425 citedByCount "0" @default.
- W4384563425 crossrefType "journal-article" @default.
- W4384563425 hasAuthorship W4384563425A5001831218 @default.
- W4384563425 hasAuthorship W4384563425A5018411567 @default.
- W4384563425 hasAuthorship W4384563425A5033351939 @default.
- W4384563425 hasAuthorship W4384563425A5057610054 @default.
- W4384563425 hasAuthorship W4384563425A5069108050 @default.
- W4384563425 hasBestOaLocation W43845634251 @default.
- W4384563425 hasConcept C104317684 @default.
- W4384563425 hasConcept C126322002 @default.
- W4384563425 hasConcept C127561419 @default.
- W4384563425 hasConcept C134018914 @default.
- W4384563425 hasConcept C185592680 @default.
- W4384563425 hasConcept C2778163477 @default.
- W4384563425 hasConcept C2779395532 @default.
- W4384563425 hasConcept C2779620165 @default.