Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384563886> ?p ?o ?g. }
- W4384563886 endingPage "112823" @default.
- W4384563886 startingPage "112823" @default.
- W4384563886 abstract "Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of immune escape in human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), an aggressive disease with poor response to immunotherapy with pembrolizumab. SMYD3 depletion induces upregulation of multiple type I interferon (IFN) response and antigen presentation machinery genes in HNSCC cells. Mechanistically, SMYD3 binds to and regulates the transcription of UHRF1, encoding for a reader of H3K9me3, which binds to H3K9me3-enriched promoters of key immune-related genes, recruits DNMT1, and silences their expression. SMYD3 further maintains the repression of immune-related genes through intragenic deposition of H4K20me3. In vivo, Smyd3 depletion induces influx of CD8+ T cells and increases sensitivity to anti-programmed death 1 (PD-1) therapy. SMYD3 overexpression is associated with decreased CD8 T cell infiltration and poor response to neoadjuvant pembrolizumab. These data support combining SMYD3 depletion strategies with checkpoint blockade to overcome anti-PD-1 resistance in HPV-negative HNSCC." @default.
- W4384563886 created "2023-07-18" @default.
- W4384563886 creator A5000955480 @default.
- W4384563886 creator A5002532060 @default.
- W4384563886 creator A5008754012 @default.
- W4384563886 creator A5013717696 @default.
- W4384563886 creator A5013968811 @default.
- W4384563886 creator A5018443439 @default.
- W4384563886 creator A5018614325 @default.
- W4384563886 creator A5023528108 @default.
- W4384563886 creator A5032842088 @default.
- W4384563886 creator A5033843763 @default.
- W4384563886 creator A5035658805 @default.
- W4384563886 creator A5039865368 @default.
- W4384563886 creator A5042231020 @default.
- W4384563886 creator A5043999924 @default.
- W4384563886 creator A5044544485 @default.
- W4384563886 creator A5046465972 @default.
- W4384563886 creator A5046732440 @default.
- W4384563886 creator A5047456350 @default.
- W4384563886 creator A5053150423 @default.
- W4384563886 creator A5056677073 @default.
- W4384563886 creator A5058226349 @default.
- W4384563886 creator A5063253432 @default.
- W4384563886 creator A5066002385 @default.
- W4384563886 creator A5067031552 @default.
- W4384563886 creator A5067478276 @default.
- W4384563886 creator A5067560793 @default.
- W4384563886 creator A5067960602 @default.
- W4384563886 creator A5068100015 @default.
- W4384563886 creator A5068180537 @default.
- W4384563886 creator A5069837203 @default.
- W4384563886 creator A5072560123 @default.
- W4384563886 creator A5073969657 @default.
- W4384563886 creator A5074041292 @default.
- W4384563886 creator A5079171795 @default.
- W4384563886 creator A5080071348 @default.
- W4384563886 creator A5082657181 @default.
- W4384563886 creator A5085910751 @default.
- W4384563886 creator A5089609746 @default.
- W4384563886 date "2023-07-01" @default.
- W4384563886 modified "2023-10-05" @default.
- W4384563886 title "SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck" @default.
- W4384563886 cites W1490231232 @default.
- W4384563886 cites W1847375317 @default.
- W4384563886 cites W1953890763 @default.
- W4384563886 cites W1977709885 @default.
- W4384563886 cites W1980020952 @default.
- W4384563886 cites W1988323955 @default.
- W4384563886 cites W1989804575 @default.
- W4384563886 cites W1994120609 @default.
- W4384563886 cites W1997103956 @default.
- W4384563886 cites W2021846928 @default.
- W4384563886 cites W2026044471 @default.
- W4384563886 cites W2036357556 @default.
- W4384563886 cites W2047852384 @default.
- W4384563886 cites W2050158252 @default.
- W4384563886 cites W2065215000 @default.
- W4384563886 cites W2074051915 @default.
- W4384563886 cites W2075459950 @default.
- W4384563886 cites W2078387182 @default.
- W4384563886 cites W2079113729 @default.
- W4384563886 cites W2103021272 @default.
- W4384563886 cites W2114843025 @default.
- W4384563886 cites W2114850502 @default.
- W4384563886 cites W2115235717 @default.
- W4384563886 cites W2123738327 @default.
- W4384563886 cites W2135527553 @default.
- W4384563886 cites W2143680521 @default.
- W4384563886 cites W2146634563 @default.
- W4384563886 cites W2146784968 @default.
- W4384563886 cites W2149441684 @default.
- W4384563886 cites W2163078458 @default.
- W4384563886 cites W2163814058 @default.
- W4384563886 cites W2166408497 @default.
- W4384563886 cites W2169373040 @default.
- W4384563886 cites W2176126538 @default.
- W4384563886 cites W2284685321 @default.
- W4384563886 cites W2287573955 @default.
- W4384563886 cites W2769571214 @default.
- W4384563886 cites W2770495427 @default.
- W4384563886 cites W2771542157 @default.
- W4384563886 cites W2774935716 @default.
- W4384563886 cites W2788797147 @default.
- W4384563886 cites W2793226176 @default.
- W4384563886 cites W2795531081 @default.
- W4384563886 cites W2809237949 @default.
- W4384563886 cites W2902678397 @default.
- W4384563886 cites W2904360942 @default.
- W4384563886 cites W2914345456 @default.
- W4384563886 cites W2920695811 @default.
- W4384563886 cites W2931309428 @default.
- W4384563886 cites W2933558643 @default.
- W4384563886 cites W2946415704 @default.
- W4384563886 cites W2952481429 @default.
- W4384563886 cites W2953678018 @default.
- W4384563886 cites W2957748026 @default.
- W4384563886 cites W2962818280 @default.