Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384564265> ?p ?o ?g. }
- W4384564265 endingPage "905.e7" @default.
- W4384564265 startingPage "893" @default.
- W4384564265 abstract "Protein glycosylation influences cellular recognition and regulates protein interactions, but how glycosylation functions alongside other common posttranslational modifications (PTMs), like tyrosine sulfation (sTyr), is unclear. We produced a library of 53 chemoenzymatically synthesized glycosulfopeptides representing N-terminal domains of human and murine P-selectin glycoprotein ligand-1 (PSGL-1), varying in sTyr and O-glycosylation (structure and site). Using these, we identified key roles of PSGL-1 O-glycosylation and sTyr in controlling interactions with specific chemokines. Results demonstrate that sTyr positively affects CCL19 and CCL21 binding to PSGL-1 N terminus, whereas O-glycan branching and sialylation reduced binding. For murine PSGL-1, interference between PTMs is greater, attributed to proximity between the two PTMs. Using fluorescence polarization, we found sTyr is a positive determinant for some chemokines. We showed that synthetic sulfopeptides are potent in decreasing chemotaxis of human dendritic cells toward CCL19 and CCL21. Our results provide new research avenues into the interplay of PTMs regulating leukocyte/chemokine interactions." @default.
- W4384564265 created "2023-07-18" @default.
- W4384564265 creator A5016108000 @default.
- W4384564265 creator A5019083727 @default.
- W4384564265 creator A5021248446 @default.
- W4384564265 creator A5023341393 @default.
- W4384564265 creator A5029218571 @default.
- W4384564265 creator A5035872776 @default.
- W4384564265 creator A5061598064 @default.
- W4384564265 creator A5064655232 @default.
- W4384564265 creator A5082895959 @default.
- W4384564265 creator A5083766160 @default.
- W4384564265 creator A5083832477 @default.
- W4384564265 creator A5085537512 @default.
- W4384564265 date "2023-08-01" @default.
- W4384564265 modified "2023-10-14" @default.
- W4384564265 title "Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation" @default.
- W4384564265 cites W14408915 @default.
- W4384564265 cites W1558765135 @default.
- W4384564265 cites W1690946024 @default.
- W4384564265 cites W1931863939 @default.
- W4384564265 cites W1978280598 @default.
- W4384564265 cites W1983177609 @default.
- W4384564265 cites W2004432012 @default.
- W4384564265 cites W2008497368 @default.
- W4384564265 cites W2010560388 @default.
- W4384564265 cites W2013909472 @default.
- W4384564265 cites W2030476868 @default.
- W4384564265 cites W2031618958 @default.
- W4384564265 cites W2037373268 @default.
- W4384564265 cites W2044890797 @default.
- W4384564265 cites W2055871852 @default.
- W4384564265 cites W2058023151 @default.
- W4384564265 cites W2061153055 @default.
- W4384564265 cites W2072918899 @default.
- W4384564265 cites W2076603801 @default.
- W4384564265 cites W2083430366 @default.
- W4384564265 cites W2085918210 @default.
- W4384564265 cites W2092664889 @default.
- W4384564265 cites W2098358122 @default.
- W4384564265 cites W2122028809 @default.
- W4384564265 cites W2139692296 @default.
- W4384564265 cites W2140449516 @default.
- W4384564265 cites W2142251390 @default.
- W4384564265 cites W2159708686 @default.
- W4384564265 cites W2168193216 @default.
- W4384564265 cites W2179531916 @default.
- W4384564265 cites W2210221948 @default.
- W4384564265 cites W2273967916 @default.
- W4384564265 cites W2336826778 @default.
- W4384564265 cites W2406555542 @default.
- W4384564265 cites W2412071739 @default.
- W4384564265 cites W2543636523 @default.
- W4384564265 cites W2728153976 @default.
- W4384564265 cites W2751565165 @default.
- W4384564265 cites W2777399253 @default.
- W4384564265 cites W2896143972 @default.
- W4384564265 cites W2953347000 @default.
- W4384564265 cites W2953910468 @default.
- W4384564265 cites W2981635494 @default.
- W4384564265 cites W2999570233 @default.
- W4384564265 cites W3011192824 @default.
- W4384564265 cites W3021411623 @default.
- W4384564265 cites W3039212038 @default.
- W4384564265 cites W3047968509 @default.
- W4384564265 cites W3136538919 @default.
- W4384564265 cites W3155392711 @default.
- W4384564265 cites W3158543463 @default.
- W4384564265 cites W3189396732 @default.
- W4384564265 cites W3202647383 @default.
- W4384564265 cites W4252353219 @default.
- W4384564265 cites W851028124 @default.
- W4384564265 cites W962458078 @default.
- W4384564265 doi "https://doi.org/10.1016/j.chembiol.2023.06.013" @default.
- W4384564265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37463583" @default.
- W4384564265 hasPublicationYear "2023" @default.
- W4384564265 type Work @default.
- W4384564265 citedByCount "1" @default.
- W4384564265 countsByYear W43845642652023 @default.
- W4384564265 crossrefType "journal-article" @default.
- W4384564265 hasAuthorship W4384564265A5016108000 @default.
- W4384564265 hasAuthorship W4384564265A5019083727 @default.
- W4384564265 hasAuthorship W4384564265A5021248446 @default.
- W4384564265 hasAuthorship W4384564265A5023341393 @default.
- W4384564265 hasAuthorship W4384564265A5029218571 @default.
- W4384564265 hasAuthorship W4384564265A5035872776 @default.
- W4384564265 hasAuthorship W4384564265A5061598064 @default.
- W4384564265 hasAuthorship W4384564265A5064655232 @default.
- W4384564265 hasAuthorship W4384564265A5082895959 @default.
- W4384564265 hasAuthorship W4384564265A5083766160 @default.
- W4384564265 hasAuthorship W4384564265A5083832477 @default.
- W4384564265 hasAuthorship W4384564265A5085537512 @default.
- W4384564265 hasConcept C108625454 @default.
- W4384564265 hasConcept C12823836 @default.
- W4384564265 hasConcept C13373296 @default.
- W4384564265 hasConcept C155138218 @default.
- W4384564265 hasConcept C170493617 @default.
- W4384564265 hasConcept C185592680 @default.