Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384564287> ?p ?o ?g. }
- W4384564287 endingPage "1793.e10" @default.
- W4384564287 startingPage "1778" @default.
- W4384564287 abstract "Unlike macrophage networks composed of long-lived tissue-resident cells within specific niches, conventional dendritic cells (cDCs) that generate a 3D network in lymph nodes (LNs) are short lived and continuously replaced by DC precursors (preDCs) from the bone marrow (BM). Here, we examined whether specific anatomical niches exist within which preDCs differentiate toward immature cDCs. In situ photoconversion and Prtn3-based fate-tracking revealed that the LN medullary cords are preferential entry sites for preDCs, serving as specific differentiation niches. Repopulation and fate-tracking approaches demonstrated that the cDC1 network unfolded from the medulla along the vascular tree toward the paracortex. During inflammation, collective maturation and migration of resident cDC1s to the paracortex created discontinuity in the medullary cDC1 network and temporarily impaired responsiveness. The decrease in local cDC1 density resulted in higher Flt3L availability in the medullary niche, which accelerated cDC1 development to restore the network. Thus, the spatiotemporal development of the cDC1 network is locally regulated in dedicated LN niches via sensing of cDC1 densities." @default.
- W4384564287 created "2023-07-18" @default.
- W4384564287 creator A5011718692 @default.
- W4384564287 creator A5013585406 @default.
- W4384564287 creator A5031460147 @default.
- W4384564287 creator A5037220835 @default.
- W4384564287 creator A5038479837 @default.
- W4384564287 creator A5052581073 @default.
- W4384564287 creator A5053205603 @default.
- W4384564287 creator A5054121448 @default.
- W4384564287 creator A5072579237 @default.
- W4384564287 creator A5078231624 @default.
- W4384564287 creator A5083429758 @default.
- W4384564287 creator A5087500670 @default.
- W4384564287 creator A5087764267 @default.
- W4384564287 creator A5091922961 @default.
- W4384564287 creator A5092487067 @default.
- W4384564287 date "2023-08-01" @default.
- W4384564287 modified "2023-10-14" @default.
- W4384564287 title "Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks" @default.
- W4384564287 cites W1512208922 @default.
- W4384564287 cites W1545564541 @default.
- W4384564287 cites W1574742039 @default.
- W4384564287 cites W1742769645 @default.
- W4384564287 cites W1752957211 @default.
- W4384564287 cites W1996384179 @default.
- W4384564287 cites W2010562798 @default.
- W4384564287 cites W2012571305 @default.
- W4384564287 cites W2014035331 @default.
- W4384564287 cites W2025635725 @default.
- W4384564287 cites W2035317074 @default.
- W4384564287 cites W2041061869 @default.
- W4384564287 cites W2046781420 @default.
- W4384564287 cites W2066033338 @default.
- W4384564287 cites W2070050178 @default.
- W4384564287 cites W2076358006 @default.
- W4384564287 cites W2087405903 @default.
- W4384564287 cites W2092632463 @default.
- W4384564287 cites W2097593754 @default.
- W4384564287 cites W2098425296 @default.
- W4384564287 cites W2104135721 @default.
- W4384564287 cites W2111435630 @default.
- W4384564287 cites W2111975769 @default.
- W4384564287 cites W2113594480 @default.
- W4384564287 cites W2131726410 @default.
- W4384564287 cites W2137670912 @default.
- W4384564287 cites W2138853264 @default.
- W4384564287 cites W2146512944 @default.
- W4384564287 cites W2149019783 @default.
- W4384564287 cites W2155326506 @default.
- W4384564287 cites W2164462649 @default.
- W4384564287 cites W2196638295 @default.
- W4384564287 cites W2230320310 @default.
- W4384564287 cites W2238741732 @default.
- W4384564287 cites W2345356016 @default.
- W4384564287 cites W2461271870 @default.
- W4384564287 cites W2469744638 @default.
- W4384564287 cites W2520191991 @default.
- W4384564287 cites W256420660 @default.
- W4384564287 cites W2586317281 @default.
- W4384564287 cites W2588618300 @default.
- W4384564287 cites W2611921452 @default.
- W4384564287 cites W2782793342 @default.
- W4384564287 cites W2787835497 @default.
- W4384564287 cites W2789293028 @default.
- W4384564287 cites W2805283148 @default.
- W4384564287 cites W2895129803 @default.
- W4384564287 cites W2902434850 @default.
- W4384564287 cites W2918516172 @default.
- W4384564287 cites W2949177718 @default.
- W4384564287 cites W2951799803 @default.
- W4384564287 cites W2953610917 @default.
- W4384564287 cites W2967647113 @default.
- W4384564287 cites W2970536272 @default.
- W4384564287 cites W2981900400 @default.
- W4384564287 cites W2983493611 @default.
- W4384564287 cites W2995261558 @default.
- W4384564287 cites W3012091956 @default.
- W4384564287 cites W3017023874 @default.
- W4384564287 cites W3123996313 @default.
- W4384564287 cites W3137573777 @default.
- W4384564287 cites W3145635506 @default.
- W4384564287 cites W3145969289 @default.
- W4384564287 cites W3196473874 @default.
- W4384564287 cites W3196565835 @default.
- W4384564287 cites W3216421083 @default.
- W4384564287 cites W4205534476 @default.
- W4384564287 cites W4321766771 @default.
- W4384564287 cites W4376256338 @default.
- W4384564287 doi "https://doi.org/10.1016/j.immuni.2023.06.020" @default.
- W4384564287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37463581" @default.
- W4384564287 hasPublicationYear "2023" @default.
- W4384564287 type Work @default.
- W4384564287 citedByCount "3" @default.
- W4384564287 countsByYear W43845642872023 @default.
- W4384564287 crossrefType "journal-article" @default.
- W4384564287 hasAuthorship W4384564287A5011718692 @default.
- W4384564287 hasAuthorship W4384564287A5013585406 @default.