Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384564308> ?p ?o ?g. }
- W4384564308 abstract "Background: Per- and polyfluoroalkyl substances (PFAS) are a component of firefighting foams used at military installations. Although high PFAS exposures have been related to cancer risks among civilian populations, the effects for military personnel are unclear. Objectives: We investigated associations between serum PFAS concentrations and testicular germ cell tumors (TGCT) among U.S. Air Force servicemen. Methods: This nested case–control study involved active-duty Air Force servicemen with sera from the Department of Defense Serum Repository. We selected 530 cases and 530 controls individually matched on birth date, race and ethnicity, year entered the service, and year of sample collection, with prediagnostic serum samples collected between 1988 and 2017. A second prediagnostic sample, collected a median of 4 y after the first, was selected for 187 case–control pairs. Seven PFAS were quantified using isotope-dilution tandem mass spectrometry. Odds ratios (ORs) and 95% confidence intervals (CIs) from conditional logistic regression adjusting for military grade, number of deployments, and, in some models, other PFAS, estimated associations between PFAS concentrations (categorized using quartiles among controls) and TGCT. Results: Elevated concentrations of some PFAS were observed for military employment in firefighting [perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid] and service at a base with high PFAS concentrations in drinking water (PFHxS). Elevated PFOS concentrations in the second sample were positively associated with TGCT [OR for fourth vs. first quartile (ORQ4)=2.6, 95% CI: 1.1, 6.4; ptrend=0.02], including after adjustment for other PFAS (ORQ4=4.6, 95% CI: 1.4, 15.1; ptrend=0.009). Associations with PFOS in the first/only samples were weak and not statistically significant. Elevated concentrations of perfluorononanoic acid were inversely associated with TGCT, whereas results were null for other PFAS. Discussion: We identified service-related predictors of PFAS concentrations and increased TGCT relative risks with elevated PFOS concentrations among Air Force servicemen. These findings warrant further investigation in other populations and military service branches. https://doi.org/10.1289/EHP12603" @default.
- W4384564308 created "2023-07-18" @default.
- W4384564308 creator A5001740629 @default.
- W4384564308 creator A5019866236 @default.
- W4384564308 creator A5029106518 @default.
- W4384564308 creator A5034058169 @default.
- W4384564308 creator A5039739229 @default.
- W4384564308 creator A5040453230 @default.
- W4384564308 creator A5050414089 @default.
- W4384564308 creator A5061960203 @default.
- W4384564308 creator A5079448339 @default.
- W4384564308 date "2023-07-01" @default.
- W4384564308 modified "2023-10-05" @default.
- W4384564308 title "A Nested Case–Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen" @default.
- W4384564308 cites W1863128385 @default.
- W4384564308 cites W1964562937 @default.
- W4384564308 cites W1973186349 @default.
- W4384564308 cites W1979486878 @default.
- W4384564308 cites W1981313532 @default.
- W4384564308 cites W1995416991 @default.
- W4384564308 cites W1996863157 @default.
- W4384564308 cites W2022405790 @default.
- W4384564308 cites W2029484646 @default.
- W4384564308 cites W2050774050 @default.
- W4384564308 cites W2054550313 @default.
- W4384564308 cites W2077774531 @default.
- W4384564308 cites W2082473356 @default.
- W4384564308 cites W2087181963 @default.
- W4384564308 cites W2112558380 @default.
- W4384564308 cites W2131809066 @default.
- W4384564308 cites W2152051151 @default.
- W4384564308 cites W2258284255 @default.
- W4384564308 cites W2337909901 @default.
- W4384564308 cites W2413389454 @default.
- W4384564308 cites W2493857981 @default.
- W4384564308 cites W2497102241 @default.
- W4384564308 cites W2808680191 @default.
- W4384564308 cites W3006980152 @default.
- W4384564308 cites W3093945145 @default.
- W4384564308 cites W3139844945 @default.
- W4384564308 cites W3206455300 @default.
- W4384564308 cites W3208861935 @default.
- W4384564308 cites W326744937 @default.
- W4384564308 cites W4231822488 @default.
- W4384564308 cites W4283761503 @default.
- W4384564308 cites W4286433358 @default.
- W4384564308 cites W4361018081 @default.
- W4384564308 doi "https://doi.org/10.1289/ehp12603" @default.
- W4384564308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37458713" @default.
- W4384564308 hasPublicationYear "2023" @default.
- W4384564308 type Work @default.
- W4384564308 citedByCount "3" @default.
- W4384564308 countsByYear W43845643082023 @default.
- W4384564308 crossrefType "journal-article" @default.
- W4384564308 hasAuthorship W4384564308A5001740629 @default.
- W4384564308 hasAuthorship W4384564308A5019866236 @default.
- W4384564308 hasAuthorship W4384564308A5029106518 @default.
- W4384564308 hasAuthorship W4384564308A5034058169 @default.
- W4384564308 hasAuthorship W4384564308A5039739229 @default.
- W4384564308 hasAuthorship W4384564308A5040453230 @default.
- W4384564308 hasAuthorship W4384564308A5050414089 @default.
- W4384564308 hasAuthorship W4384564308A5061960203 @default.
- W4384564308 hasAuthorship W4384564308A5079448339 @default.
- W4384564308 hasBestOaLocation W43845643081 @default.
- W4384564308 hasConcept C107872376 @default.
- W4384564308 hasConcept C126322002 @default.
- W4384564308 hasConcept C146304588 @default.
- W4384564308 hasConcept C156957248 @default.
- W4384564308 hasConcept C185592680 @default.
- W4384564308 hasConcept C2775979320 @default.
- W4384564308 hasConcept C44249647 @default.
- W4384564308 hasConcept C68443243 @default.
- W4384564308 hasConcept C71924100 @default.
- W4384564308 hasConcept C99454951 @default.
- W4384564308 hasConceptScore W4384564308C107872376 @default.
- W4384564308 hasConceptScore W4384564308C126322002 @default.
- W4384564308 hasConceptScore W4384564308C146304588 @default.
- W4384564308 hasConceptScore W4384564308C156957248 @default.
- W4384564308 hasConceptScore W4384564308C185592680 @default.
- W4384564308 hasConceptScore W4384564308C2775979320 @default.
- W4384564308 hasConceptScore W4384564308C44249647 @default.
- W4384564308 hasConceptScore W4384564308C68443243 @default.
- W4384564308 hasConceptScore W4384564308C71924100 @default.
- W4384564308 hasConceptScore W4384564308C99454951 @default.
- W4384564308 hasIssue "7" @default.
- W4384564308 hasLocation W43845643081 @default.
- W4384564308 hasLocation W43845643082 @default.
- W4384564308 hasLocation W43845643083 @default.
- W4384564308 hasOpenAccess W4384564308 @default.
- W4384564308 hasPrimaryLocation W43845643081 @default.
- W4384564308 hasRelatedWork W2009748009 @default.
- W4384564308 hasRelatedWork W2040394175 @default.
- W4384564308 hasRelatedWork W2055211800 @default.
- W4384564308 hasRelatedWork W2116633522 @default.
- W4384564308 hasRelatedWork W2147746313 @default.
- W4384564308 hasRelatedWork W2151165832 @default.
- W4384564308 hasRelatedWork W3023816155 @default.
- W4384564308 hasRelatedWork W4309740539 @default.
- W4384564308 hasRelatedWork W4361879683 @default.
- W4384564308 hasRelatedWork W4361901229 @default.