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- W4384564720 abstract "Gentamicin (GTN) is an extensively used aminoglycoside. Contrary to its antibacterial potential, it can induce oxidative stress in several organs, including kidney. Amentoflavone (AMN) is a biflavonoid with conspicuous pharmacological activities. The current examination was held to estimate the curative efficacy of AMN to antagonize the nephrotoxic effects instigated by GTN. 48 albino rats were separated into IV groups: control group, GTN administrated group (80mgk-1 intraperitoneally), the GTN + AMN treated group (80mgkg-1 + 40mgkg-1) and only amn administrated group (40mgkg-1). Following 30 days of administration, results showed that GTN disturbed antioxidant enzymes i.e., glutathione (GSH), glutathione reductase (GSR), glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT) activity, besides elevated malondialdehyde (MDA) along with reactive oxygen species (ROS) level. Besides this, level of inflammatory cytokines involving interleukin-6 (IL-6), nuclear factor-kappa B (NF-κB), interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α) & cyclo-oxygenase-2 (COX-2) were escalated. Furthermore, treatment with GTN enhanced the expression of apoptotic proteins comprising of Bax, caspase-9 along with caspase-3 besides lessened the expression of Bcl-2. In addition to this, GTN reduced the level of albumin, creatinine clearance & augmented the level of creatinine, urea, urobilinogen, urinary protein as well as kidney injury molecules-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) as well as instigated various histopathological damages. However, co-treated group (AMN + GTN) revoked abovementioned renal dysregulations instigated by GTN. Taken together, AMN could significantly counteract GTN-instigated nephrotoxic effect due to its antioxidant capabilities." @default.
- W4384564720 created "2023-07-18" @default.
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- W4384564720 date "2023-10-01" @default.
- W4384564720 modified "2023-10-16" @default.
- W4384564720 title "Antioxidant, anti-inflammatory and anti-apoptotic effects of amentoflavone on gentamicin-induced kidney damage in rats" @default.
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- W4384564720 doi "https://doi.org/10.1016/j.jksus.2023.102791" @default.
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