Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384564775> ?p ?o ?g. }
- W4384564775 endingPage "121953" @default.
- W4384564775 startingPage "121953" @default.
- W4384564775 abstract "Neonatal seizures are severe pathologies which may result in long-term neurological consequences. High plasma concentrations of homocysteine - hyperhomocysteinemia (hHCy) - are associated with epilepsy. In the present study, we evaluated susceptibility to seizure of neonatal rats with prenatal hHCy.Prenatal hHCy was induced by feeding females with a high-methionine diet. Experiments were performed on pups during the first three postnatal weeks. Flurothyl-induced epileptic behavior was assessed according to Racine's scale. Epileptiform activity in the hippocampus was recorded using electrophysiological methods. The balance of excitation/inhibition, functional GABAergic inhibition and GABA reversal potential in hippocampal neurons were analyzed.Rats with hHCy developed more severe stages of behavioral patterns during flurothyl-induced epilepsy with shorter latency. Electrophysiological recordings demonstrated higher background neuronal activity in rats with hHCy. Seizure-like events triggered by flurothyl (in vivo) or 4-aminopyridine (in vitro) showed shorter latency, higher power and amplitude. An increased glutamate/GABA synaptic ratio was shown in the pyramidal neurons of rats with hHCy and more slices demonstrated excitation by isoguvacine, a selective GABA(A) receptor agonist, during the first and second postnatal weeks. The GABA driving force and the reversal potential of GABA(A) currents were more positive during the second postnatal week for hHCy rats.The higher susceptibility to seizures in rats with prenatal hHCy due to a shift in the balance of excitation/inhibition toward excitation may underlie the clinical evidence about the association of hHCy with an increased risk of epilepsy." @default.
- W4384564775 created "2023-07-18" @default.
- W4384564775 creator A5022152990 @default.
- W4384564775 creator A5023221550 @default.
- W4384564775 creator A5027670823 @default.
- W4384564775 creator A5039229305 @default.
- W4384564775 creator A5041824506 @default.
- W4384564775 creator A5059198783 @default.
- W4384564775 date "2023-09-01" @default.
- W4384564775 modified "2023-10-06" @default.
- W4384564775 title "Maternal hyperhomocysteinemia increases seizures susceptibility of neonatal rats" @default.
- W4384564775 cites W181510641 @default.
- W4384564775 cites W1878092990 @default.
- W4384564775 cites W1968382122 @default.
- W4384564775 cites W1971932912 @default.
- W4384564775 cites W1974385252 @default.
- W4384564775 cites W1975011155 @default.
- W4384564775 cites W1977202953 @default.
- W4384564775 cites W1987521851 @default.
- W4384564775 cites W1987990061 @default.
- W4384564775 cites W1991091655 @default.
- W4384564775 cites W1991180711 @default.
- W4384564775 cites W1999511826 @default.
- W4384564775 cites W2002889165 @default.
- W4384564775 cites W2003078245 @default.
- W4384564775 cites W2003097264 @default.
- W4384564775 cites W2016541635 @default.
- W4384564775 cites W2019015591 @default.
- W4384564775 cites W2019707718 @default.
- W4384564775 cites W2024642025 @default.
- W4384564775 cites W2025076095 @default.
- W4384564775 cites W2028772345 @default.
- W4384564775 cites W2032613394 @default.
- W4384564775 cites W2036162045 @default.
- W4384564775 cites W2036219462 @default.
- W4384564775 cites W2042398065 @default.
- W4384564775 cites W2045095925 @default.
- W4384564775 cites W2051592475 @default.
- W4384564775 cites W2055345919 @default.
- W4384564775 cites W2056313120 @default.
- W4384564775 cites W2057684943 @default.
- W4384564775 cites W2064363302 @default.
- W4384564775 cites W2066909217 @default.
- W4384564775 cites W2066992394 @default.
- W4384564775 cites W2067976748 @default.
- W4384564775 cites W2069767789 @default.
- W4384564775 cites W2075555698 @default.
- W4384564775 cites W2076362005 @default.
- W4384564775 cites W2082480208 @default.
- W4384564775 cites W2092959372 @default.
- W4384564775 cites W2099387266 @default.
- W4384564775 cites W2103946141 @default.
- W4384564775 cites W2120681929 @default.
- W4384564775 cites W2132669570 @default.
- W4384564775 cites W2140723805 @default.
- W4384564775 cites W2145742822 @default.
- W4384564775 cites W2153955459 @default.
- W4384564775 cites W2157154651 @default.
- W4384564775 cites W2159204518 @default.
- W4384564775 cites W2164752897 @default.
- W4384564775 cites W2233171690 @default.
- W4384564775 cites W2462539746 @default.
- W4384564775 cites W2483528517 @default.
- W4384564775 cites W2505495934 @default.
- W4384564775 cites W2528301026 @default.
- W4384564775 cites W2530872782 @default.
- W4384564775 cites W2546512774 @default.
- W4384564775 cites W2546757431 @default.
- W4384564775 cites W2564487226 @default.
- W4384564775 cites W2759501766 @default.
- W4384564775 cites W2777631080 @default.
- W4384564775 cites W2805045270 @default.
- W4384564775 cites W2806111367 @default.
- W4384564775 cites W2900894832 @default.
- W4384564775 cites W2901393568 @default.
- W4384564775 cites W2948457966 @default.
- W4384564775 cites W2948969934 @default.
- W4384564775 cites W2952147612 @default.
- W4384564775 cites W2980832231 @default.
- W4384564775 cites W2998569728 @default.
- W4384564775 cites W3006653245 @default.
- W4384564775 cites W3033102927 @default.
- W4384564775 cites W3038417811 @default.
- W4384564775 cites W3092625492 @default.
- W4384564775 cites W3119613717 @default.
- W4384564775 cites W3129900856 @default.
- W4384564775 cites W3157362385 @default.
- W4384564775 cites W3176302064 @default.
- W4384564775 cites W4205655789 @default.
- W4384564775 cites W4207056716 @default.
- W4384564775 cites W4210614123 @default.
- W4384564775 cites W4281384404 @default.
- W4384564775 cites W4291464386 @default.
- W4384564775 cites W4306412465 @default.
- W4384564775 cites W4312113808 @default.
- W4384564775 cites W4313202817 @default.
- W4384564775 cites W795011208 @default.
- W4384564775 doi "https://doi.org/10.1016/j.lfs.2023.121953" @default.