FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384564776> ?p ?o ?g. }

• W4384564776 endingPage "119540" @default.
• W4384564776 startingPage "119540" @default.
• W4384564776 abstract "Interleukin-6 (IL-6) is a multi-effective cytokine involved in multiple immune responses. Whether fibroblasts also turn out to be a cytokine IL-6 factory during interaction with Treponema pallidum is not yet understood. To explore whether fibroblasts participate in inflammation due to syphilis, a series of experiments were performed to explore the role of T. pallidum lipoprotein Tp47 in IL-6 production in human dermal fibroblasts. The Toll-like receptor 2 (TLR2) and participating signalling pathways in this process were also evaluated. The results showed that the expressions of IL-6 and the protein levels of TLR2 in fibroblasts were upregulated after stimulation with Tp47, and this effect was impeded by the TLR2 inhibitor C29. In addition, Tp47 promoted the phosphorylation of p38, PI3K/Akt, and nuclear factor-kappaB (NF-κB), and the translocation of NF-κB in fibroblasts. Moreover, p38, PI3K, and NF-κB inhibitors significantly reduced IL-6 production in fibroblasts stimulated with Tp47. Furthermore, the TLR2 inhibitor C29 inhibited the phosphorylation of p38, Akt, and NF-κB, and the translocation of NF-κB in fibroblasts. In conclusion, our results showed that Tp47 enhanced IL-6 secretion in human dermal fibroblasts through TLR2 via p38, PI3K/Akt, and NF-κB signalling pathways. These findings contribute to our understanding of syphilis inflammation." @default.
• W4384564776 created "2023-07-18" @default.
• W4384564776 creator A5000660688 @default.
• W4384564776 creator A5020161890 @default.
• W4384564776 creator A5033211215 @default.
• W4384564776 creator A5034640580 @default.
• W4384564776 creator A5037125555 @default.
• W4384564776 creator A5058814232 @default.
• W4384564776 creator A5062316263 @default.
• W4384564776 creator A5069888386 @default.
• W4384564776 date "2023-10-01" @default.
• W4384564776 modified "2023-09-26" @default.
• W4384564776 title "Treponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and NF-κB signalling pathways" @default.
• W4384564776 cites W1881979012 @default.
• W4384564776 cites W1954080920 @default.
• W4384564776 cites W1971281373 @default.
• W4384564776 cites W1977455495 @default.
• W4384564776 cites W2001473220 @default.
• W4384564776 cites W2047573521 @default.
• W4384564776 cites W2052183876 @default.
• W4384564776 cites W2058633294 @default.
• W4384564776 cites W2071378904 @default.
• W4384564776 cites W2076616598 @default.
• W4384564776 cites W2086905324 @default.
• W4384564776 cites W2096166085 @default.
• W4384564776 cites W2104386484 @default.
• W4384564776 cites W2105480794 @default.
• W4384564776 cites W2109491705 @default.
• W4384564776 cites W2135029107 @default.
• W4384564776 cites W2148658155 @default.
• W4384564776 cites W2162778769 @default.
• W4384564776 cites W2267931422 @default.
• W4384564776 cites W2470405284 @default.
• W4384564776 cites W2574419680 @default.
• W4384564776 cites W2709334163 @default.
• W4384564776 cites W2793325503 @default.
• W4384564776 cites W2805197831 @default.
• W4384564776 cites W2811481829 @default.
• W4384564776 cites W2897747897 @default.
• W4384564776 cites W2938774134 @default.
• W4384564776 cites W2943476675 @default.
• W4384564776 cites W2944130575 @default.
• W4384564776 cites W2946437991 @default.
• W4384564776 cites W2961517015 @default.
• W4384564776 cites W2994878813 @default.
• W4384564776 cites W3021867869 @default.
• W4384564776 cites W3207328751 @default.
• W4384564776 cites W4220665045 @default.
• W4384564776 cites W4237409271 @default.
• W4384564776 cites W4281678551 @default.
• W4384564776 doi "https://doi.org/10.1016/j.bbamcr.2023.119540" @default.
• W4384564776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37468070" @default.
• W4384564776 hasPublicationYear "2023" @default.
• W4384564776 type Work @default.
• W4384564776 citedByCount "0" @default.
• W4384564776 crossrefType "journal-article" @default.
• W4384564776 hasAuthorship W4384564776A5000660688 @default.
• W4384564776 hasAuthorship W4384564776A5020161890 @default.
• W4384564776 hasAuthorship W4384564776A5033211215 @default.
• W4384564776 hasAuthorship W4384564776A5034640580 @default.
• W4384564776 hasAuthorship W4384564776A5037125555 @default.
• W4384564776 hasAuthorship W4384564776A5058814232 @default.
• W4384564776 hasAuthorship W4384564776A5062316263 @default.
• W4384564776 hasAuthorship W4384564776A5069888386 @default.
• W4384564776 hasConcept C11960822 @default.
• W4384564776 hasConcept C136449434 @default.
• W4384564776 hasConcept C185592680 @default.
• W4384564776 hasConcept C203014093 @default.
• W4384564776 hasConcept C2776070231 @default.
• W4384564776 hasConcept C2776709828 @default.
• W4384564776 hasConcept C2776914184 @default.
• W4384564776 hasConcept C2778690821 @default.
• W4384564776 hasConcept C2781236682 @default.
• W4384564776 hasConcept C502942594 @default.
• W4384564776 hasConcept C51551487 @default.
• W4384564776 hasConcept C62478195 @default.
• W4384564776 hasConcept C75217442 @default.
• W4384564776 hasConcept C86554907 @default.
• W4384564776 hasConcept C86803240 @default.
• W4384564776 hasConcept C8891405 @default.
• W4384564776 hasConcept C95444343 @default.
• W4384564776 hasConcept C97029542 @default.
• W4384564776 hasConceptScore W4384564776C11960822 @default.
• W4384564776 hasConceptScore W4384564776C136449434 @default.
• W4384564776 hasConceptScore W4384564776C185592680 @default.
• W4384564776 hasConceptScore W4384564776C203014093 @default.
• W4384564776 hasConceptScore W4384564776C2776070231 @default.
• W4384564776 hasConceptScore W4384564776C2776709828 @default.
• W4384564776 hasConceptScore W4384564776C2776914184 @default.
• W4384564776 hasConceptScore W4384564776C2778690821 @default.
• W4384564776 hasConceptScore W4384564776C2781236682 @default.
• W4384564776 hasConceptScore W4384564776C502942594 @default.
• W4384564776 hasConceptScore W4384564776C51551487 @default.
• W4384564776 hasConceptScore W4384564776C62478195 @default.
• W4384564776 hasConceptScore W4384564776C75217442 @default.
• W4384564776 hasConceptScore W4384564776C86554907 @default.
• W4384564776 hasConceptScore W4384564776C86803240 @default.
• W4384564776 hasConceptScore W4384564776C8891405 @default.

• next