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- W4384564862 abstract "Endocrine disruptors (EDCs) are emerging contaminants that are harmful to health. Human exposure occurs mainly through ingestion or dermal contact, but inhalation could be an additional exposure route; therefore, this study was conducted to evaluate the oestrogenic activity of airborne particulate matter (PM). Outdoor PM was collected for a year in five Italian sites and extracted with organic solvents (four seasonal extracts/site). The oestrogenic activity was assessed using a gene reporter assay (MELN), and the risk to human health through inhalation was quantified using the results. Moreover, extracts were analysed to assess cytotoxicity (WST-1 and LDH assays) on human bronchial cells (BEAS-2B). The extracts induced a significant cytotoxicity and oestrogenic activity. Oestrogenic activity showed a seasonal trend and was correlated with concentrations of benzo(a)pyrene and toxic equivalency factor. Although a low inhalation cancer risk was found, this study confirmed that oestrogenic activity in air could contribute to overall health risks due to EDC exposure." @default.
- W4384564862 created "2023-07-18" @default.
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- W4384564862 date "2023-09-01" @default.
- W4384564862 modified "2023-09-24" @default.
- W4384564862 title "Can oestrogenic activity in air contribute to the overall body burden of endocrine disruptors?" @default.
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- W4384564862 doi "https://doi.org/10.1016/j.etap.2023.104232" @default.
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