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- W4384564962 endingPage "106231" @default.
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- W4384564962 abstract "Astrocytes are in contact with the vasculature, neurons, oligodendrocytes and microglia, forming a local network with various functions critical for brain homeostasis. One of the primary responders to brain injury are astrocytes as they detect neuronal and vascular damage, change their phenotype with morphological, proteomic and transcriptomic transformations for an adaptive response. The role of astrocytic responses in brain dysfunction is not fully elucidated in adult, and even less described in the developing brain. Children are vulnerable to traumatic brain injury (TBI), which represents a leading cause of death and disability in the pediatric population. Pediatric brain trauma, even with mild severity, can lead to long-term health complications, such as cognitive impairments, emotional disorders and social dysfunction later in life. To date, the underlying pathophysiology is still not fully understood. In this review, we focus on the astrocytic response in pediatric TBI and propose a potential immune role of the astrocyte in response to trauma. We discuss the contribution of astrocytes in the local inflammatory cascades and secretion of various immunomodulatory factors involved in the recruitment of local microglial cells and peripheral immune cells through cerebral blood vessels. Taken together, we propose that early changes in the astrocytic phenotype can alter normal development of the brain, with long-term consequences on neurological outcomes, as described in preclinical models and patients." @default.
- W4384564962 created "2023-07-18" @default.
- W4384564962 creator A5044696234 @default.
- W4384564962 creator A5052687230 @default.
- W4384564962 creator A5076174254 @default.
- W4384564962 creator A5092487158 @default.
- W4384564962 date "2023-09-01" @default.
- W4384564962 modified "2023-10-14" @default.
- W4384564962 title "Do astrocytes act as immune cells after pediatric TBI?" @default.
- W4384564962 cites W1497157822 @default.
- W4384564962 cites W1503384439 @default.
- W4384564962 cites W1513901802 @default.
- W4384564962 cites W1547158446 @default.
- W4384564962 cites W1594747697 @default.
- W4384564962 cites W1600183911 @default.
- W4384564962 cites W1609153296 @default.
- W4384564962 cites W1640041938 @default.
- W4384564962 cites W1825604636 @default.
- W4384564962 cites W1907720726 @default.
- W4384564962 cites W1970863115 @default.
- W4384564962 cites W1971125401 @default.
- W4384564962 cites W1975372045 @default.
- W4384564962 cites W1976244656 @default.
- W4384564962 cites W1976442735 @default.
- W4384564962 cites W1977941840 @default.
- W4384564962 cites W1980405505 @default.
- W4384564962 cites W1985035247 @default.
- W4384564962 cites W1986462650 @default.
- W4384564962 cites W1989808869 @default.
- W4384564962 cites W1991182430 @default.
- W4384564962 cites W1994915568 @default.
- W4384564962 cites W1996347218 @default.
- W4384564962 cites W1998196587 @default.
- W4384564962 cites W1999004826 @default.
- W4384564962 cites W2002247284 @default.
- W4384564962 cites W2004008188 @default.
- W4384564962 cites W2004751985 @default.
- W4384564962 cites W2010247798 @default.
- W4384564962 cites W2012789061 @default.
- W4384564962 cites W2015551349 @default.
- W4384564962 cites W2016285277 @default.
- W4384564962 cites W2018455601 @default.
- W4384564962 cites W2021604946 @default.
- W4384564962 cites W2024549838 @default.
- W4384564962 cites W2025059233 @default.
- W4384564962 cites W2025269107 @default.
- W4384564962 cites W2026209203 @default.
- W4384564962 cites W2026652437 @default.
- W4384564962 cites W2027917639 @default.
- W4384564962 cites W2030688762 @default.
- W4384564962 cites W2031517843 @default.
- W4384564962 cites W2032730787 @default.
- W4384564962 cites W2033591334 @default.
- W4384564962 cites W2033665331 @default.
- W4384564962 cites W2033692470 @default.
- W4384564962 cites W2034264974 @default.
- W4384564962 cites W2035891650 @default.
- W4384564962 cites W2042822864 @default.
- W4384564962 cites W2043291008 @default.
- W4384564962 cites W2043503785 @default.
- W4384564962 cites W2045655730 @default.
- W4384564962 cites W2046832808 @default.
- W4384564962 cites W2052249006 @default.
- W4384564962 cites W2053937389 @default.
- W4384564962 cites W2056745170 @default.
- W4384564962 cites W2056760893 @default.
- W4384564962 cites W2057596964 @default.
- W4384564962 cites W2063703188 @default.
- W4384564962 cites W2064189084 @default.
- W4384564962 cites W2065082003 @default.
- W4384564962 cites W2065183388 @default.
- W4384564962 cites W2065802840 @default.
- W4384564962 cites W2068400560 @default.
- W4384564962 cites W2069498125 @default.
- W4384564962 cites W2071425128 @default.
- W4384564962 cites W2071623114 @default.
- W4384564962 cites W2074515925 @default.
- W4384564962 cites W2078442598 @default.
- W4384564962 cites W2082107386 @default.
- W4384564962 cites W2084566588 @default.
- W4384564962 cites W2085610321 @default.
- W4384564962 cites W2085878699 @default.
- W4384564962 cites W2090431569 @default.
- W4384564962 cites W2095384937 @default.
- W4384564962 cites W2099572487 @default.
- W4384564962 cites W2099929136 @default.
- W4384564962 cites W2102622410 @default.
- W4384564962 cites W2103044571 @default.
- W4384564962 cites W2107233898 @default.
- W4384564962 cites W2109909801 @default.
- W4384564962 cites W2111128053 @default.
- W4384564962 cites W2118661818 @default.
- W4384564962 cites W2120742253 @default.
- W4384564962 cites W2122828560 @default.
- W4384564962 cites W2125236750 @default.
- W4384564962 cites W2129567809 @default.
- W4384564962 cites W2129571101 @default.
- W4384564962 cites W2137401544 @default.