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- W4384565633 abstract "Descurainia sophia seeds methanol extract showed significant anti-influenza activity and we tried to isolate anti-influenza compounds from the D. sophia extract. D. sophia seeds were extracted with 80% methanol and fractionated with n-hexane, ethyl acetate, CHCl3 and n-butanol. The anti-influenza activity of each fraction was assessed using sulforhodamine B (SRB) method in A549 cells, human-derived lung cancer cells. The ethyl acetate and CHCl3 fractions showed the most potent anti-influenza activity. Seven compounds were isolated from CHCl₃ fraction and identified 1-decanol (1), 2-(3,4-dihydroxy-2-methylenebutoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (2), daucosterol (3), isorhamnetin (4), quercetin (5), sinapic acid (6), and helveticoside (7) by spectroscopic data such as UV, IR, ¹H-NMR, SUP13/SUPC-NMR and mass spectroscopy. Anti-influenza activities of isolated compounds were evaluated using SRB method in A549 cells. Compounds 3, 4 and 7 had significant antiinfluenza activity in a dose-dependent manner." @default.
- W4384565633 created "2023-07-18" @default.
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- W4384565633 date "2023-06-30" @default.
- W4384565633 modified "2023-09-25" @default.
- W4384565633 title "Anti-influenza Compounds Isolated from Descurainia sophia Seeds" @default.
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- W4384565633 doi "https://doi.org/10.20307/nps.2023.29.2.113" @default.
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