FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384567819> ?p ?o ?g. }

• W4384567819 abstract "<h3>Introduction</h3> An abnormal Coronary Flow Reserve (CFR) is independently associated with impaired prognosis. The Coronary Vasomotor Disorders International Study Group (COVADIS) define a CFR of <2.0 as being evidence for coronary microvascular dysfunction. As such, CFR has a role in clinical practice for the diagnosis of microvascular angina. At the time of invasive coronary angiography, CFR can be measured by instrumenting the coronary artery with a combined Doppler/pressure or thermistor/pressure diagnostic guidewire. The Pressure-bounded CFR (Pb-CFR) has been proposed as a means of estimating the range in which the “true” CFR lies, as calculated from measured pressure readings at the time of invasive angiography. This theoretically obviates the need for invasive CFR measurement. We aimed to assess the clinical utility and sensitivity of Pb-CFR in patients undergoing coronary angiography, including those with ischaemia and no obstructive coronary artery disease (INOCA). <h3>Methods</h3> We retrospectively analysed data for patients undergoing invasive coronary microvascular function testing with a combined temperature/pressure diagnostic guidewire (PressureWire X, Abbott Vascular) in two large, tertiary-care cardiac hospitals between 2017 and 2022. Baseline demographics, clinical history, vital signs and coronary physiology data were obtained. Invasive aortic and coronary pressures, including the fractional flow reserve (FFR) were used to calculate the Pb-CFR (Figure 1). This value was compared to the thermodilution-derived CFR (thermoCFR) measured at the time of angiography. Agreement between the Pb-CFR and thermoCFR was then assessed. All patients provided written informed consent for research and/or clinical audit in the participating institutions. <h3>Results</h3> We obtained data in n= 768 coronary vessels from n=694 patients. Clinical characteristics include median age 61 years, 52.8% female, 47.5% smoking history, 53.1% hypertension, 14.6% diabetes mellitus, 11.1% previous myocardial infarction, 4.8% atrial fibrillation and 84.1% presenting as chronic coronary syndromes. Other characteristics are summarised in Table 1. The median FFR was 0.87 (IQR 0.83-0.92). FFR was ≤0.80 in n= 124 vessels studied. The median thermoCFR was 2.7 (IQR 1.9-3.9). The thermoCFR value fell within the Pb-CFR range in only 17.4% of cases. Using a cut-off of <2.0, the upper limit of Pb-CFR agreed with thermoCFR in 52.3% of cases, with a sensitivity for detecting CFR<2.0 of 72.6% (151/208) and specificity 55.6% (299/538). This improved to 72.1% agreement in vessels with FFR ≤0.80, sensitivity 78.7% (37/47) and specificity 68.0% (51/75). <h3>Conclusions</h3> Pb-CFR can be retrospectively derived from vessels with measured resting pressures and FFR, but correlates poorly with invasively measured CFR. Accuracy is only improved when FFR ≤0.80, which negates its utility in patients with INOCA. <h3>Conflict of Interest</h3> None" @default.
• W4384567819 created "2023-07-18" @default.
• W4384567819 creator A5012277022 @default.
• W4384567819 creator A5022051708 @default.
• W4384567819 creator A5040940965 @default.
• W4384567819 creator A5042816189 @default.
• W4384567819 creator A5062232887 @default.
• W4384567819 creator A5079308912 @default.
• W4384567819 creator A5085330671 @default.
• W4384567819 date "2023-06-01" @default.
• W4384567819 modified "2023-09-28" @default.
• W4384567819 title "40 Comparing pressure-bound coronary flow reserve versus thermodilution-derived coronary flow reserve" @default.
• W4384567819 doi "https://doi.org/10.1136/heartjnl-2023-bcs.40" @default.
• W4384567819 hasPublicationYear "2023" @default.
• W4384567819 type Work @default.
• W4384567819 citedByCount "0" @default.
• W4384567819 crossrefType "proceedings-article" @default.
• W4384567819 hasAuthorship W4384567819A5012277022 @default.
• W4384567819 hasAuthorship W4384567819A5022051708 @default.
• W4384567819 hasAuthorship W4384567819A5040940965 @default.
• W4384567819 hasAuthorship W4384567819A5042816189 @default.
• W4384567819 hasAuthorship W4384567819A5062232887 @default.
• W4384567819 hasAuthorship W4384567819A5079308912 @default.
• W4384567819 hasAuthorship W4384567819A5085330671 @default.
• W4384567819 hasBestOaLocation W43845678191 @default.
• W4384567819 hasConcept C126322002 @default.
• W4384567819 hasConcept C164705383 @default.
• W4384567819 hasConcept C178853913 @default.
• W4384567819 hasConcept C2777987666 @default.
• W4384567819 hasConcept C2778213512 @default.
• W4384567819 hasConcept C2778425758 @default.
• W4384567819 hasConcept C2778707443 @default.
• W4384567819 hasConcept C3019004856 @default.
• W4384567819 hasConcept C39124391 @default.
• W4384567819 hasConcept C500558357 @default.
• W4384567819 hasConcept C71924100 @default.
• W4384567819 hasConceptScore W4384567819C126322002 @default.
• W4384567819 hasConceptScore W4384567819C164705383 @default.
• W4384567819 hasConceptScore W4384567819C178853913 @default.
• W4384567819 hasConceptScore W4384567819C2777987666 @default.
• W4384567819 hasConceptScore W4384567819C2778213512 @default.
• W4384567819 hasConceptScore W4384567819C2778425758 @default.
• W4384567819 hasConceptScore W4384567819C2778707443 @default.
• W4384567819 hasConceptScore W4384567819C3019004856 @default.
• W4384567819 hasConceptScore W4384567819C39124391 @default.
• W4384567819 hasConceptScore W4384567819C500558357 @default.
• W4384567819 hasConceptScore W4384567819C71924100 @default.
• W4384567819 hasLocation W43845678191 @default.
• W4384567819 hasOpenAccess W4384567819 @default.
• W4384567819 hasPrimaryLocation W43845678191 @default.
• W4384567819 hasRelatedWork W2056990779 @default.
• W4384567819 hasRelatedWork W2544598118 @default.
• W4384567819 hasRelatedWork W2901491112 @default.
• W4384567819 hasRelatedWork W3032522106 @default.
• W4384567819 hasRelatedWork W3085613861 @default.
• W4384567819 hasRelatedWork W3145040827 @default.
• W4384567819 hasRelatedWork W3187558306 @default.
• W4384567819 hasRelatedWork W3206201424 @default.
• W4384567819 hasRelatedWork W4286721830 @default.
• W4384567819 hasRelatedWork W4313347031 @default.
• W4384567819 isParatext "false" @default.
• W4384567819 isRetracted "false" @default.
• W4384567819 workType "article" @default.