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• W4384568139 abstract "<h3>Introduction</h3> There is a high burden of gout in patients with coronary heart disease, heart failure, and atrial fibrillation, given shared risk factors including inflammation, and use of therapeutic agents such as diuretics which predispose to gout. However, there remains a paucity of data on the true burden of gout in hospitalized patients with atrial fibrillation and its impact on clinical outcomes and hospital length of stay. We sought to determine baseline characteristics of atrial fibrillation patients with and without gout, and in-hospital impact on mortality, length of stay (LOS) and total cost. <h3>Methods</h3> Patients with atrial fibrillation, with and without gout, were abstracted using International Classification of Diseases 10th Modification from the National Inpatient Sample Database (NIS). Baseline demographic, geographic, and hospital-related data along with associated comorbidities were also abstracted. The two groups were compared and outcomes of mortality, LOS and hospitalization cost were analysed. <h3>Results</h3> From 2016-2019, 3,058,934 atrial fibrillation patients were included in the analysis out of which 132,925 (4.3%) patients had gout. The gout cohort consisted of older patients (mean age, 74.3 vs 73.3 years), predominantly males (68.9% vs 48.4%), and had a lower prevalence of hypertension (42.0% vs 50.3%) when compared to atrial fibrillation patients without gout (p<0.01). However, patients with gout had a higher concomitant history of heart failure (27.0% vs 19.7%), hyperlipidaemia (61.1% vs 50.0%), ventricular tachycardia (2.1% vs 1.6%), peripheral vascular disease (5.8% vs 4.2%), obesity (23.1% vs 15.3%), smoking history (32.6% vs 28.3%), alcoholism (4.7% vs 3.7%), COPD (18.4% vs 17.4%), pulmonary hypertension (4.0% vs 3.0%), chronic kidney disease (17.5% vs 7.6%), chronic liver disease (3.3% vs 2.5%) and anaemia (24.3% vs 17.8%) [p<0.01]. Patients with gout had a higher mean LOS (3.9 vs 3.5 days, p=0.004) and mean charge ($48,137 vs $46,561, p<0.001). In patients undergoing catheter ablation, mortality was higher in patients with concomitant gout and AF (1.3% vs 0.4%, p=0.013) as well as in-patient mean LOS (4.5 days vs 3.7 days, p<0.001). <h3>Conclusion</h3> Presence of gout in patients with atrial fibrillation significantly increases LOS and health care costs but is associated with decreased mortality. Data regarding outcomes of patients with AF and comorbid gout is sparse and further studies, for example analysing effect of colchicine, are necessary to evaluate the lower mortality in this cohort. <h3>Conflict of Interest</h3> Nil" @default.
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• W4384568139 date "2023-06-01" @default.
• W4384568139 modified "2023-10-16" @default.
• W4384568139 title "107 Characteristics and in-hospital outcomes of gout in atrial fibrillation patients" @default.
• W4384568139 doi "https://doi.org/10.1136/heartjnl-2023-bcs.107" @default.
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