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- W4384568460 abstract "Heterocyclic compounds especially, five or six-member heterocyclic compounds, having one to three hetero-atoms in their nucleus take part in metabolism of all living cells. And this information gives the lead for synthesizing heterocyclic derivatives. This research work has focused on development of new method for synthesis of some new amino acid substituted 1,2,4-trizole derivative from 1, 3, 4-Oxadizole nucleus. The nucleus of the 1, 3, 4-Oxadizole was first produced by reaction of Isoniazide and 3-chlorobenzeldehyde which is then converted into 1,2,4-trizole derivative by the loss of water molecule. After that incorporation of different amino acid (luecine and glycin) leads new amino acid substituted 1,2,4-trizole derivative. The newly synthesized derivative Compound A1 and A2 were characterized by optical rotation, melting point, TLC, UV spectroscopy and IR. The antibacterial was screened using Disc diffusion method with ciprofloxacin as reference drug and antioxidant activity by in-vitro DPPH method using ascorbic acid as standard drug. Synthesized compound A1 showed maximum MIC against S. aureus as compared to Compound A2. For antioxidant activity, compound A1 showed maximum percentage inhibition as compared to Compound A2." @default.
- W4384568460 created "2023-07-18" @default.
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- W4384568460 date "2023-05-31" @default.
- W4384568460 modified "2023-09-23" @default.
- W4384568460 title "Microwave-Assisted Synthesis of New 4-Amino Acid Substituted 1,2,4-Triazole Derivative Derived from 1,2,3-Oxadiazole Nucleus and Their Anti-Bacterial and Anti-Oxidant Potential" @default.
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- W4384568460 doi "https://doi.org/10.52711/0974-360x.2023.00382" @default.
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