Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384575897> ?p ?o ?g. }
- W4384575897 endingPage "332" @default.
- W4384575897 startingPage "325" @default.
- W4384575897 abstract "Recognition of peptide/MHC complexes by αβ TCRs has traditionally been viewed through the lens of conventional receptor-ligand theory. Recent work, however, has shown that TCR recognition and T cell signaling can be profoundly influenced and tuned by mechanical forces. One outcome of applied force is the catch bond, where TCR dissociation rates decrease (half-lives increase) when limited force is applied. Although catch bond behavior is believed to be widespread in biology, its counterintuitive nature coupled with the difficulties of describing mechanisms at the structural level have resulted in considerable mystique. In this review, we demonstrate that viewing catch bonds through the lens of energy landscapes, barriers, and the ensuing reaction rates can help demystify catch bonding and provide a foundation on which atomic-level TCR catch bond mechanisms can be built." @default.
- W4384575897 created "2023-07-18" @default.
- W4384575897 creator A5077419243 @default.
- W4384575897 creator A5079168905 @default.
- W4384575897 creator A5082462618 @default.
- W4384575897 date "2023-08-01" @default.
- W4384575897 modified "2023-09-27" @default.
- W4384575897 title "The Energetic Landscape of Catch Bonds in TCR Interfaces" @default.
- W4384575897 cites W1602179460 @default.
- W4384575897 cites W1778590861 @default.
- W4384575897 cites W1861250630 @default.
- W4384575897 cites W1884700299 @default.
- W4384575897 cites W1966086662 @default.
- W4384575897 cites W1967359088 @default.
- W4384575897 cites W1972631323 @default.
- W4384575897 cites W1974004204 @default.
- W4384575897 cites W1974782594 @default.
- W4384575897 cites W1978034352 @default.
- W4384575897 cites W1989199118 @default.
- W4384575897 cites W1989623499 @default.
- W4384575897 cites W1995039527 @default.
- W4384575897 cites W2005785099 @default.
- W4384575897 cites W2006070959 @default.
- W4384575897 cites W2009688266 @default.
- W4384575897 cites W2011584482 @default.
- W4384575897 cites W2014095962 @default.
- W4384575897 cites W2021534482 @default.
- W4384575897 cites W2022046477 @default.
- W4384575897 cites W2025735516 @default.
- W4384575897 cites W2028813239 @default.
- W4384575897 cites W2030080371 @default.
- W4384575897 cites W2030214324 @default.
- W4384575897 cites W2032984660 @default.
- W4384575897 cites W2041392692 @default.
- W4384575897 cites W2045527508 @default.
- W4384575897 cites W2047115921 @default.
- W4384575897 cites W2052192720 @default.
- W4384575897 cites W2065635440 @default.
- W4384575897 cites W2071423255 @default.
- W4384575897 cites W2084677920 @default.
- W4384575897 cites W2087427893 @default.
- W4384575897 cites W2089666002 @default.
- W4384575897 cites W2090400738 @default.
- W4384575897 cites W2094213517 @default.
- W4384575897 cites W2099598754 @default.
- W4384575897 cites W2101030382 @default.
- W4384575897 cites W2101271238 @default.
- W4384575897 cites W2104418223 @default.
- W4384575897 cites W2106320506 @default.
- W4384575897 cites W2113773464 @default.
- W4384575897 cites W2117612738 @default.
- W4384575897 cites W2123590972 @default.
- W4384575897 cites W2124186838 @default.
- W4384575897 cites W2128493116 @default.
- W4384575897 cites W2132826139 @default.
- W4384575897 cites W2136169984 @default.
- W4384575897 cites W2142843496 @default.
- W4384575897 cites W2145550546 @default.
- W4384575897 cites W2151958162 @default.
- W4384575897 cites W2152645204 @default.
- W4384575897 cites W2155708268 @default.
- W4384575897 cites W2160648230 @default.
- W4384575897 cites W2162959818 @default.
- W4384575897 cites W2166523933 @default.
- W4384575897 cites W2310257575 @default.
- W4384575897 cites W2343508276 @default.
- W4384575897 cites W2347077379 @default.
- W4384575897 cites W2417253274 @default.
- W4384575897 cites W2425907854 @default.
- W4384575897 cites W2545968080 @default.
- W4384575897 cites W2592976135 @default.
- W4384575897 cites W2616210709 @default.
- W4384575897 cites W2722104519 @default.
- W4384575897 cites W2741797758 @default.
- W4384575897 cites W2744739931 @default.
- W4384575897 cites W2744957082 @default.
- W4384575897 cites W2748062037 @default.
- W4384575897 cites W2749092846 @default.
- W4384575897 cites W2786841916 @default.
- W4384575897 cites W2810745017 @default.
- W4384575897 cites W2835938797 @default.
- W4384575897 cites W2884809460 @default.
- W4384575897 cites W2897614399 @default.
- W4384575897 cites W2899591402 @default.
- W4384575897 cites W2900084201 @default.
- W4384575897 cites W2900747079 @default.
- W4384575897 cites W2911501853 @default.
- W4384575897 cites W2933229048 @default.
- W4384575897 cites W2952713729 @default.
- W4384575897 cites W2958230540 @default.
- W4384575897 cites W2963886278 @default.
- W4384575897 cites W2965645347 @default.
- W4384575897 cites W2974245877 @default.
- W4384575897 cites W2994717723 @default.
- W4384575897 cites W3003340507 @default.
- W4384575897 cites W3037354511 @default.
- W4384575897 cites W3049123519 @default.
- W4384575897 cites W3049184299 @default.