Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384626705> ?p ?o ?g. }
- W4384626705 endingPage "34569" @default.
- W4384626705 startingPage "34554" @default.
- W4384626705 abstract "Nowadays, the combined use of chemotherapy and photodynamic therapy (PDT) remains the most popular strategy for cancer treatment with high theraprutic efficacy. However, targeted therapy with the on-demand release of drugs is what most clinical treatments lack, leading to heavy side effects. Herein, a new CD44-targeted and red-light-activatable nanosystem, Ru-HA@DOX nanoparticles (NPs), was developed by conjugating hydrophilic biodegradable hyaluronic acid (HA) and hydrophobic photoresponsive ruthenium (Ru) complexes, which could encapsulate the chemotherapeutic drug doxrubicin (DOX). Ru-HA@DOX NPs can selectively accumulate at the tumor through the enhanced permeability and retention (EPR) effect and CD44-mediated endocytosis, thus avoiding off-target toxicity during circulation. After 660 nm of irradiation at the tumor site, Ru-HA@DOX NPs, as a photoactivatable bomb, was split via the photocleavable Ru-N coordination bond to fast release DOX and produce singlet oxygen (1O2) for PDT. In general, Ru-HA@DOX NPs retained its integrity before irradiation and possessed minimal cytotoxicity, while under red-light irradiation, Ru-HA@DOX NPs showed significant cytotoxicity due to the release of DOX and production of 1O2 at the tumor. Chemotherapy-PDT of Ru-HA@DOX NPs resulted in a significant inhibition of tumor growth in A549-tumor-bearing mice and reduced the cardiotoxicity of DOX. Therefore, this study offers a novel CD44-targeted drug-delivery system with on-demand drug release for synergistic chemotherapy-PDT." @default.
- W4384626705 created "2023-07-19" @default.
- W4384626705 creator A5003065832 @default.
- W4384626705 creator A5012342690 @default.
- W4384626705 creator A5023484982 @default.
- W4384626705 creator A5023826377 @default.
- W4384626705 creator A5039123158 @default.
- W4384626705 creator A5041911754 @default.
- W4384626705 creator A5063481044 @default.
- W4384626705 creator A5067090257 @default.
- W4384626705 creator A5083759592 @default.
- W4384626705 creator A5087054079 @default.
- W4384626705 date "2023-07-18" @default.
- W4384626705 modified "2023-10-16" @default.
- W4384626705 title "CD44-Targeted Photoactivatable Polymeric Nanosystem with On-Demand Drug Release as a “Photoactivatable Bomb” for Combined Photodynamic Therapy–Chemotherapy of Cancer" @default.
- W4384626705 cites W2003163223 @default.
- W4384626705 cites W2033612573 @default.
- W4384626705 cites W2034642786 @default.
- W4384626705 cites W2061532024 @default.
- W4384626705 cites W2072498342 @default.
- W4384626705 cites W2095505118 @default.
- W4384626705 cites W2104799708 @default.
- W4384626705 cites W2106787323 @default.
- W4384626705 cites W2113924048 @default.
- W4384626705 cites W2122265695 @default.
- W4384626705 cites W2130784417 @default.
- W4384626705 cites W2132925947 @default.
- W4384626705 cites W2200801731 @default.
- W4384626705 cites W2208847826 @default.
- W4384626705 cites W2263667682 @default.
- W4384626705 cites W2559999038 @default.
- W4384626705 cites W2605214678 @default.
- W4384626705 cites W2735519026 @default.
- W4384626705 cites W2737792392 @default.
- W4384626705 cites W2750972108 @default.
- W4384626705 cites W2772249853 @default.
- W4384626705 cites W2777338358 @default.
- W4384626705 cites W2884685900 @default.
- W4384626705 cites W2889359317 @default.
- W4384626705 cites W2889646458 @default.
- W4384626705 cites W2890825810 @default.
- W4384626705 cites W2897031729 @default.
- W4384626705 cites W2905124068 @default.
- W4384626705 cites W2913220041 @default.
- W4384626705 cites W2917351875 @default.
- W4384626705 cites W2929038257 @default.
- W4384626705 cites W3034840694 @default.
- W4384626705 cites W3034856439 @default.
- W4384626705 cites W3046853626 @default.
- W4384626705 cites W3080700318 @default.
- W4384626705 cites W3081472276 @default.
- W4384626705 cites W3093272187 @default.
- W4384626705 cites W3103361989 @default.
- W4384626705 cites W3107402128 @default.
- W4384626705 cites W3111401131 @default.
- W4384626705 cites W3114180258 @default.
- W4384626705 cites W3166619205 @default.
- W4384626705 cites W3206384984 @default.
- W4384626705 cites W4206168331 @default.
- W4384626705 cites W4281630742 @default.
- W4384626705 doi "https://doi.org/10.1021/acsami.3c05645" @default.
- W4384626705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37462246" @default.
- W4384626705 hasPublicationYear "2023" @default.
- W4384626705 type Work @default.
- W4384626705 citedByCount "0" @default.
- W4384626705 crossrefType "journal-article" @default.
- W4384626705 hasAuthorship W4384626705A5003065832 @default.
- W4384626705 hasAuthorship W4384626705A5012342690 @default.
- W4384626705 hasAuthorship W4384626705A5023484982 @default.
- W4384626705 hasAuthorship W4384626705A5023826377 @default.
- W4384626705 hasAuthorship W4384626705A5039123158 @default.
- W4384626705 hasAuthorship W4384626705A5041911754 @default.
- W4384626705 hasAuthorship W4384626705A5063481044 @default.
- W4384626705 hasAuthorship W4384626705A5067090257 @default.
- W4384626705 hasAuthorship W4384626705A5083759592 @default.
- W4384626705 hasAuthorship W4384626705A5087054079 @default.
- W4384626705 hasConcept C109316439 @default.
- W4384626705 hasConcept C12554922 @default.
- W4384626705 hasConcept C126322002 @default.
- W4384626705 hasConcept C126511603 @default.
- W4384626705 hasConcept C171250308 @default.
- W4384626705 hasConcept C178790620 @default.
- W4384626705 hasConcept C185592680 @default.
- W4384626705 hasConcept C192562407 @default.
- W4384626705 hasConcept C202751555 @default.
- W4384626705 hasConcept C20639190 @default.
- W4384626705 hasConcept C2776694085 @default.
- W4384626705 hasConcept C2777516457 @default.
- W4384626705 hasConcept C2778233292 @default.
- W4384626705 hasConcept C2779820397 @default.
- W4384626705 hasConcept C2780035454 @default.
- W4384626705 hasConcept C2780932548 @default.
- W4384626705 hasConcept C2781303535 @default.
- W4384626705 hasConcept C2781323092 @default.
- W4384626705 hasConcept C29730261 @default.
- W4384626705 hasConcept C502942594 @default.
- W4384626705 hasConcept C540031477 @default.
- W4384626705 hasConcept C55493867 @default.