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• W4384627091 abstract "This review provides an update on recent advances in mechanistic studies of thromboinflammatory mechanisms that contribute to the disease pathology in sickle cell disease (SCD). There is a focus on novel pathways, clinical relevance, and translational potential of these findings. We hope to encourage more advances in this area to reduce organ damage in young patients prior to gene therapy, and to serve the aging SCD patient population.Novel insights into the roles of neutrophils, the ADAMTS-13/VWF axis, oxidative stress, and the intrinsic coagulation cascade, as well as relevant clinical trials, are discussed.Several studies implicate dysregulation of the ADAMTS-13/VWF axis as playing a major role in vaso-occlusive events (VOE) in SCD. Another highlight is reducing iron overload, which has beneficial effects on erythrocyte and neutrophil function that reduce VOE and inflammation. Multiple studies suggest that targeting HO-1/ROS in erythrocytes, platelets, and endothelium can attenuate disease pathology. New insights into coagulation activation identify intrinsic coagulation factor XII as a central regulator of many thromboinflammatory pathologies in SCD. The complement cascade and modulators of neutrophil function and release of neutrophil extracellular traps are also discussed." @default.
• W4384627091 created "2023-07-19" @default.
• W4384627091 creator A5011299651 @default.
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• W4384627091 date "2023-07-14" @default.
• W4384627091 modified "2023-10-17" @default.
• W4384627091 title "The invisible string of coagulation, complement, iron, and inflammation in sickle cell disease" @default.
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• W4384627091 doi "https://doi.org/10.1097/moh.0000000000000773" @default.
• W4384627091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37462409" @default.
• W4384627091 hasPublicationYear "2023" @default.
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