FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384627412> ?p ?o ?g. }

• W4384627412 endingPage "1030" @default.
• W4384627412 startingPage "1020" @default.
• W4384627412 abstract "Abstract Objective This study aimed to investigate the correlation between the expression levels of C3b and C4b in human gingival tissue (GT) and gingival crevicular fluid (GCF) and disease severity in human periodontitis and to determine whether C3b and C4b are significant site‐specific complementary diagnostic markers for periodontitis. Background A variety of biomarkers that have potential for informing diagnoses of periodontitis have been proposed. The complement components C3b and C4b were found to be positively correlated with disease severity. The therapeutic effect of targeting C3b and C4b on inflammatory bone loss in experimental periodontitis models has been studied. However, studies on the diagnostic potential of the gingival C3b and C4b expression levels for periodontitis are scarce. Methods The expression levels of C3b and C4b in the GT and GCF were investigated via immunohistochemistry and enzyme‐linked immunosorbent assay, respectively. The correlation between the expression levels of C3b and C4b and disease severity with probing depth as well as the clinical attachment level were determined. To evaluate the diagnostic accuracy of the C3b and C4b expression levels at the periodontitis sites, the receiver operating characteristic (ROC) curve, cut‐off point, area under the ROC curve, sensitivity, and specificity were analyzed. Results The expression levels of C3b and C4b in human GT and GCF were significantly positively correlated with periodontitis severity. The expression levels of combined C3b + C4b in the GT can significantly differentiate the disease status at the tissue level ( p < .0001). Similarly, the expression levels of C3b + C4b in GCF can statistically distinguish periodontitis sites from healthy ones ( p < .0001). Conclusions Locally deposited C3b and C4b were positively correlated with periodontitis severity and recognized as site‐specific diagnostic biomarkers for clinicopathological features in periodontitis. The association between the C3b and C4b network and periodontitis may be further understood and provide a basis for the development of novel screening as well as diagnostic and therapeutic strategies for periodontitis." @default.
• W4384627412 created "2023-07-19" @default.
• W4384627412 creator A5010356868 @default.
• W4384627412 creator A5010850545 @default.
• W4384627412 creator A5014230085 @default.
• W4384627412 creator A5014250467 @default.
• W4384627412 creator A5035130258 @default.
• W4384627412 creator A5042888831 @default.
• W4384627412 creator A5061741374 @default.
• W4384627412 creator A5080871070 @default.
• W4384627412 creator A5081866212 @default.
• W4384627412 date "2023-07-18" @default.
• W4384627412 modified "2023-10-16" @default.
• W4384627412 title "Complement components C3b and C4b as potential reliable site‐specific diagnostic biomarkers for periodontitis" @default.
• W4384627412 cites W1810648060 @default.
• W4384627412 cites W1884635290 @default.
• W4384627412 cites W1969787878 @default.
• W4384627412 cites W2007559967 @default.
• W4384627412 cites W2011705160 @default.
• W4384627412 cites W2020008649 @default.
• W4384627412 cites W2020667482 @default.
• W4384627412 cites W2025335147 @default.
• W4384627412 cites W2066151306 @default.
• W4384627412 cites W2069697252 @default.
• W4384627412 cites W2113408951 @default.
• W4384627412 cites W2135800998 @default.
• W4384627412 cites W2136648677 @default.
• W4384627412 cites W2143901124 @default.
• W4384627412 cites W2147711127 @default.
• W4384627412 cites W2159578097 @default.
• W4384627412 cites W2337946020 @default.
• W4384627412 cites W2397512299 @default.
• W4384627412 cites W2466285639 @default.
• W4384627412 cites W2564311184 @default.
• W4384627412 cites W2565176913 @default.
• W4384627412 cites W2741071665 @default.
• W4384627412 cites W2778590077 @default.
• W4384627412 cites W2809416758 @default.
• W4384627412 cites W2921267532 @default.
• W4384627412 cites W2942790287 @default.
• W4384627412 cites W3013777079 @default.
• W4384627412 cites W3014529666 @default.
• W4384627412 cites W3022540031 @default.
• W4384627412 cites W3023972696 @default.
• W4384627412 cites W3043302681 @default.
• W4384627412 cites W3133428707 @default.
• W4384627412 cites W3134991047 @default.
• W4384627412 cites W3198761043 @default.
• W4384627412 cites W4214585063 @default.
• W4384627412 cites W4224236934 @default.
• W4384627412 cites W4225568570 @default.
• W4384627412 cites W4239400484 @default.
• W4384627412 cites W4281653686 @default.
• W4384627412 cites W4292528167 @default.
• W4384627412 cites W4293769629 @default.
• W4384627412 cites W4309660867 @default.
• W4384627412 cites W4315640714 @default.
• W4384627412 doi "https://doi.org/10.1111/jre.13164" @default.
• W4384627412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37462259" @default.
• W4384627412 hasPublicationYear "2023" @default.
• W4384627412 type Work @default.
• W4384627412 citedByCount "0" @default.
• W4384627412 crossrefType "journal-article" @default.
• W4384627412 hasAuthorship W4384627412A5010356868 @default.
• W4384627412 hasAuthorship W4384627412A5010850545 @default.
• W4384627412 hasAuthorship W4384627412A5014230085 @default.
• W4384627412 hasAuthorship W4384627412A5014250467 @default.
• W4384627412 hasAuthorship W4384627412A5035130258 @default.
• W4384627412 hasAuthorship W4384627412A5042888831 @default.
• W4384627412 hasAuthorship W4384627412A5061741374 @default.
• W4384627412 hasAuthorship W4384627412A5080871070 @default.
• W4384627412 hasAuthorship W4384627412A5081866212 @default.
• W4384627412 hasConcept C111684460 @default.
• W4384627412 hasConcept C126322002 @default.
• W4384627412 hasConcept C142724271 @default.
• W4384627412 hasConcept C159654299 @default.
• W4384627412 hasConcept C203014093 @default.
• W4384627412 hasConcept C204232928 @default.
• W4384627412 hasConcept C2778883934 @default.
• W4384627412 hasConcept C2780385504 @default.
• W4384627412 hasConcept C58471807 @default.
• W4384627412 hasConcept C71924100 @default.
• W4384627412 hasConceptScore W4384627412C111684460 @default.
• W4384627412 hasConceptScore W4384627412C126322002 @default.
• W4384627412 hasConceptScore W4384627412C142724271 @default.
• W4384627412 hasConceptScore W4384627412C159654299 @default.
• W4384627412 hasConceptScore W4384627412C203014093 @default.
• W4384627412 hasConceptScore W4384627412C204232928 @default.
• W4384627412 hasConceptScore W4384627412C2778883934 @default.
• W4384627412 hasConceptScore W4384627412C2780385504 @default.
• W4384627412 hasConceptScore W4384627412C58471807 @default.
• W4384627412 hasConceptScore W4384627412C71924100 @default.
• W4384627412 hasFunder F4320322004 @default.
• W4384627412 hasIssue "5" @default.
• W4384627412 hasLocation W43846274121 @default.
• W4384627412 hasLocation W43846274122 @default.
• W4384627412 hasOpenAccess W4384627412 @default.
• W4384627412 hasPrimaryLocation W43846274121 @default.

• next