Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384627442> ?p ?o ?g. }
- W4384627442 abstract "Despite advances in biomedical research, fracture nonunion rates have remained stable throughout the years. Long-bone fractures have a high likelihood of nonunion, but the specific biological pathways involved in this severe consequence are unknown. Fractures often heal in an organized sequence, including the production of a hematoma and an early stage of inflammation, the development of a soft callus and hard callus, and eventually the stage of bone remodeling. Deficient healing can result in a persistent bone defect with instability, discomfort, and loss of function. In the treatment of nonunions, mesenchymal stem cells (MSCs) prove to be a promising and safe alternative to the standard therapeutic strategies. Moreover, novel scaffolds are being created in order to use a synergistic biomimetic technique to rapidly generate bone tissue. MSCs respond to acellular biomimetic matrices by regenerating bone. Extracellular vesicles (EVs) derived from MSCs have recently gained interest in the field of musculoskeletal regeneration. Although many of these techniques and technologies are still in the preclinical stage and have not yet been approved for use in humans, novel approaches to accelerate bone healing via MSCs and/or MSC derivatives have the potential to reduce the physical, economic, and social burdens associated with nonhealing fractures and bone defects. In this review, we focus on providing an up-to-date summary of recent scientific studies dealing with the treatment of nonunion fractures in clinical and preclinical settings employing MSC-based therapeutic techniques." @default.
- W4384627442 created "2023-07-19" @default.
- W4384627442 creator A5002592093 @default.
- W4384627442 creator A5046705684 @default.
- W4384627442 creator A5049900497 @default.
- W4384627442 creator A5071013688 @default.
- W4384627442 date "2023-01-01" @default.
- W4384627442 modified "2023-10-12" @default.
- W4384627442 title "Stem Cells and Their Derivatives: An Implication for the Regeneration of Nonunion Fractures" @default.
- W4384627442 cites W1551118958 @default.
- W4384627442 cites W1648831305 @default.
- W4384627442 cites W1966994557 @default.
- W4384627442 cites W1972785590 @default.
- W4384627442 cites W1978776792 @default.
- W4384627442 cites W1979493465 @default.
- W4384627442 cites W1980248118 @default.
- W4384627442 cites W1994169116 @default.
- W4384627442 cites W1996656034 @default.
- W4384627442 cites W1998614074 @default.
- W4384627442 cites W2010247131 @default.
- W4384627442 cites W2022577997 @default.
- W4384627442 cites W2028641849 @default.
- W4384627442 cites W2029205063 @default.
- W4384627442 cites W2032051482 @default.
- W4384627442 cites W2043082218 @default.
- W4384627442 cites W2062547357 @default.
- W4384627442 cites W2073473970 @default.
- W4384627442 cites W2074226229 @default.
- W4384627442 cites W2074645659 @default.
- W4384627442 cites W2079830794 @default.
- W4384627442 cites W2080418767 @default.
- W4384627442 cites W2081225883 @default.
- W4384627442 cites W2084128762 @default.
- W4384627442 cites W2091250479 @default.
- W4384627442 cites W2104295191 @default.
- W4384627442 cites W2109937981 @default.
- W4384627442 cites W2111463416 @default.
- W4384627442 cites W2114430387 @default.
- W4384627442 cites W2128829595 @default.
- W4384627442 cites W2141045060 @default.
- W4384627442 cites W2151253830 @default.
- W4384627442 cites W2159999899 @default.
- W4384627442 cites W2164045396 @default.
- W4384627442 cites W2211541075 @default.
- W4384627442 cites W2270560321 @default.
- W4384627442 cites W2335178464 @default.
- W4384627442 cites W2421141056 @default.
- W4384627442 cites W2527248350 @default.
- W4384627442 cites W2549903646 @default.
- W4384627442 cites W2554244120 @default.
- W4384627442 cites W2575108039 @default.
- W4384627442 cites W2587573568 @default.
- W4384627442 cites W2591880036 @default.
- W4384627442 cites W2603605162 @default.
- W4384627442 cites W2604655234 @default.
- W4384627442 cites W2615201841 @default.
- W4384627442 cites W2616005400 @default.
- W4384627442 cites W2779915224 @default.
- W4384627442 cites W2779981387 @default.
- W4384627442 cites W2790917774 @default.
- W4384627442 cites W2801124446 @default.
- W4384627442 cites W2808973838 @default.
- W4384627442 cites W2891768161 @default.
- W4384627442 cites W2899279394 @default.
- W4384627442 cites W2899949902 @default.
- W4384627442 cites W2905083850 @default.
- W4384627442 cites W2955032361 @default.
- W4384627442 cites W2997363480 @default.
- W4384627442 cites W3007016063 @default.
- W4384627442 cites W3007395396 @default.
- W4384627442 cites W3009973917 @default.
- W4384627442 cites W3014382901 @default.
- W4384627442 cites W3128862004 @default.
- W4384627442 cites W3207448104 @default.
- W4384627442 doi "https://doi.org/10.1177/09636897231183530" @default.
- W4384627442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37462248" @default.
- W4384627442 hasPublicationYear "2023" @default.
- W4384627442 type Work @default.
- W4384627442 citedByCount "0" @default.
- W4384627442 crossrefType "journal-article" @default.
- W4384627442 hasAuthorship W4384627442A5002592093 @default.
- W4384627442 hasAuthorship W4384627442A5046705684 @default.
- W4384627442 hasAuthorship W4384627442A5049900497 @default.
- W4384627442 hasAuthorship W4384627442A5071013688 @default.
- W4384627442 hasBestOaLocation W43846274421 @default.
- W4384627442 hasConcept C141071460 @default.
- W4384627442 hasConcept C142724271 @default.
- W4384627442 hasConcept C171056886 @default.
- W4384627442 hasConcept C198826908 @default.
- W4384627442 hasConcept C2779330695 @default.
- W4384627442 hasConcept C28328180 @default.
- W4384627442 hasConcept C60644358 @default.
- W4384627442 hasConcept C71924100 @default.
- W4384627442 hasConcept C8337478 @default.
- W4384627442 hasConcept C86803240 @default.
- W4384627442 hasConcept C95444343 @default.
- W4384627442 hasConceptScore W4384627442C141071460 @default.
- W4384627442 hasConceptScore W4384627442C142724271 @default.
- W4384627442 hasConceptScore W4384627442C171056886 @default.
- W4384627442 hasConceptScore W4384627442C198826908 @default.