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- W4384641241 abstract "The nicotinamide adenine dinucleotide (NAD+ ) precursor nicotinamide mononucleotide (NMN) is a proposed therapy for age-related disease, whereby it is assumed that NMN is incorporated into NAD+ through the canonical recycling pathway. During oral delivery, NMN is exposed to the gut microbiome, which could modify the NAD+ metabolome through enzyme activities not present in the mammalian host. We show that orally delivered NMN can undergo deamidation and incorporation in mammalian tissue via the de novo pathway, which is reduced in animals treated with antibiotics to ablate the gut microbiome. Antibiotics increased the availability of NAD+ metabolites, suggesting the microbiome could be in competition with the host for dietary NAD+ precursors. These findings highlight new interactions between NMN and the gut microbiome." @default.
- W4384641241 created "2023-07-19" @default.
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- W4384641241 date "2023-08-09" @default.
- W4384641241 modified "2023-10-14" @default.
- W4384641241 title "Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation" @default.
- W4384641241 cites W1497983863 @default.
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- W4384641241 cites W1717068853 @default.
- W4384641241 cites W183985036 @default.
- W4384641241 cites W1915186474 @default.
- W4384641241 cites W1970554352 @default.
- W4384641241 cites W1979573684 @default.
- W4384641241 cites W1988834965 @default.
- W4384641241 cites W2012848603 @default.
- W4384641241 cites W2013527743 @default.
- W4384641241 cites W2014300705 @default.
- W4384641241 cites W2018338154 @default.
- W4384641241 cites W2022450215 @default.
- W4384641241 cites W2026001461 @default.
- W4384641241 cites W2038011036 @default.
- W4384641241 cites W2039774617 @default.
- W4384641241 cites W2040163572 @default.
- W4384641241 cites W2040388799 @default.
- W4384641241 cites W2046766469 @default.
- W4384641241 cites W2048878532 @default.
- W4384641241 cites W2052830757 @default.
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- W4384641241 cites W2056279562 @default.
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- W4384641241 cites W2062200458 @default.
- W4384641241 cites W2068054518 @default.
- W4384641241 cites W2068128334 @default.
- W4384641241 cites W2069623008 @default.
- W4384641241 cites W2074985619 @default.
- W4384641241 cites W2082393205 @default.
- W4384641241 cites W2090442368 @default.
- W4384641241 cites W2097948853 @default.
- W4384641241 cites W2098215193 @default.
- W4384641241 cites W2108536847 @default.
- W4384641241 cites W2118964113 @default.
- W4384641241 cites W2131271579 @default.
- W4384641241 cites W2139212304 @default.
- W4384641241 cites W2157296254 @default.
- W4384641241 cites W2168268248 @default.
- W4384641241 cites W2171748049 @default.
- W4384641241 cites W2179683104 @default.
- W4384641241 cites W2294959829 @default.
- W4384641241 cites W2343193821 @default.
- W4384641241 cites W2403097891 @default.
- W4384641241 cites W2427895239 @default.
- W4384641241 cites W2468492854 @default.
- W4384641241 cites W2499764253 @default.
- W4384641241 cites W2526023525 @default.
- W4384641241 cites W2530388030 @default.
- W4384641241 cites W2531683815 @default.
- W4384641241 cites W2531686927 @default.
- W4384641241 cites W2537034621 @default.
- W4384641241 cites W2546015443 @default.
- W4384641241 cites W2722324655 @default.
- W4384641241 cites W2759726048 @default.
- W4384641241 cites W2775008495 @default.
- W4384641241 cites W2775095764 @default.
- W4384641241 cites W2785101149 @default.
- W4384641241 cites W2791288341 @default.
- W4384641241 cites W2791758888 @default.
- W4384641241 cites W2800314655 @default.
- W4384641241 cites W2888356897 @default.
- W4384641241 cites W2902471330 @default.
- W4384641241 cites W2903608921 @default.
- W4384641241 cites W2903854778 @default.
- W4384641241 cites W2922434422 @default.
- W4384641241 cites W2938269442 @default.
- W4384641241 cites W2944227504 @default.
- W4384641241 cites W2978252541 @default.
- W4384641241 cites W3005675840 @default.
- W4384641241 cites W3010636379 @default.
- W4384641241 cites W3185239096 @default.
- W4384641241 cites W3213809584 @default.
- W4384641241 cites W4283257951 @default.
- W4384641241 cites W4295214823 @default.
- W4384641241 cites W4311572757 @default.
- W4384641241 doi "https://doi.org/10.1002/1873-3468.14698" @default.
- W4384641241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37463842" @default.
- W4384641241 hasPublicationYear "2023" @default.
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