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- W4384642719 abstract "Decreased NADH-induced and increased reduced FADH2 -induced respiration rates at high temperatures are associated with thermal tolerance in Drosophila. Here, we determined whether this change was associated with adjustments of adenosine triphosphate (ATP) production rate and coupling efficiency (ATP/O) in Drosophila melanogaster. We show that decreased pyruvate + malate oxidation at 35°C is associated with a collapse of ATP synthesis and a drop in ATP/O ratio. However, adding succinate triggered a full compensation of both oxygen consumption and ATP synthesis rates at this high temperature. Addition of glycerol-3-phosphate (G3P) led to a huge increase in respiration with no further advantage in terms of ATP production. We conclude that succinate is the only alternative substrate able to compensate both oxygen consumption and ATP production rates during oxidative phosphorylation at high temperature, which has important implications for thermal adaptation." @default.
- W4384642719 created "2023-07-19" @default.
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- W4384642719 date "2023-07-27" @default.
- W4384642719 modified "2023-09-26" @default.
- W4384642719 title "Succinate oxidation rescues mitochondrial <scp>ATP</scp> synthesis at high temperature in <i>Drosophila melanogaster</i>" @default.
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- W4384642719 doi "https://doi.org/10.1002/1873-3468.14701" @default.
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