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- W4384659318 abstract "Triatoma infestans (Klug) is an insect recognized as not only an important vector of South-American trypanosomiasis (Chagas disease) but also a model of specific cellular morphofunctional organization and epigenetic characteristics. The purpose of the present review is to highlight certain cellular processes that are particularly unveiled in T. infestans, such as 1) somatic polyploidy involving nuclear and cell fusions that generate giant nuclei; 2) diversification of nuclear phenotypes in the Malpighian tubules during insect development; 3) heterochromatin compartmentalization into large bodies with specific spatial distribution and presumed mobility in the cell nuclei; 4) chromatin remodeling and co-occurrence of necrosis and apoptosis in the Malpighian tubules under stress conditions; 5) epigenetic markers; 6) unexplained response of heterochromatin to valproic acid, an epidrug that inhibits histone deacetylases and induces DNA demethylation in other cell systems. These cellular processes and epigenetic characteristics emphasize the role of T. infestans as an attractive model for cellular research." @default.
- W4384659318 created "2023-07-20" @default.
- W4384659318 creator A5045058897 @default.
- W4384659318 date "2023-07-18" @default.
- W4384659318 modified "2023-09-23" @default.
- W4384659318 title "Nuclear Morphofunctional Organization and Epigenetic Characteristics in Somatic Cells of <em>Triatoma infestans</em> (Klug)" @default.
- W4384659318 doi "https://doi.org/10.20944/preprints202307.1158.v1" @default.
- W4384659318 hasPublicationYear "2023" @default.
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