Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384661640> ?p ?o ?g. }
- W4384661640 abstract "Agricultural production is seriously threatened by plant pathogens. The development of new fungicides with high efficacy and low toxicity is urgently needed. In this study, a series of pyrazole carboxamide thiazole derivatives were designed, synthesized, and evaluated for their antifungal activities against nine plant pathogens in vitro. Bioassay results showed that most compounds (3i, 5i, 6i, 7i, 9i, 12i, 16i, 19i, and 23i) exhibited good antifungal activities against Valsa mali. In particular, compounds 6i and 19i exhibited better antifungal activities against Valsa mali with EC50 values of 1.77 and 1.97 mg/L, respectively, than the control drug boscalid (EC50 = 9.19 mg/L). Additionally, compound 23i exhibited excellent inhibitory activity against Rhizoctonia solani, with an EC50 value of 3.79 mg/L. Compound 6i at 40 mg/L showed a satisfactory in vivo protective effect against Valsa mali. Scanning electron microscopy analyses revealed that compound 6i could significantly damage the surface morphology to interfere with the growth of Valsa mali. In molecular docking, the results showed that compound 6i interacts with TRP O: 173, SER P: 39, TYR Q: 58, and ARG P: 43 of succinate dehydrogenase (SDH) through hydrogen bonding and σ–π interaction, and its binding mode is similar to that of boscalid and SDH. The enzyme activity experiment also further verified its action mode. Our studies suggested that pyrazole carboxamide thiazole derivative 6i provided a valuable reference for the further development of succinate dehydrogenase inhibitors." @default.
- W4384661640 created "2023-07-20" @default.
- W4384661640 creator A5010607811 @default.
- W4384661640 creator A5015996920 @default.
- W4384661640 creator A5027018165 @default.
- W4384661640 creator A5039989373 @default.
- W4384661640 creator A5054419328 @default.
- W4384661640 creator A5067447649 @default.
- W4384661640 creator A5087592842 @default.
- W4384661640 creator A5092492209 @default.
- W4384661640 date "2023-07-18" @default.
- W4384661640 modified "2023-10-06" @default.
- W4384661640 title "Design, Synthesis, and Evaluation of Antifungal Bioactivity of Novel Pyrazole Carboxamide Thiazole Derivatives as SDH Inhibitors" @default.
- W4384661640 cites W1989966205 @default.
- W4384661640 cites W2034055287 @default.
- W4384661640 cites W2102855570 @default.
- W4384661640 cites W2401400842 @default.
- W4384661640 cites W2515878624 @default.
- W4384661640 cites W2542625872 @default.
- W4384661640 cites W2582817511 @default.
- W4384661640 cites W2765503840 @default.
- W4384661640 cites W2769194429 @default.
- W4384661640 cites W2789803372 @default.
- W4384661640 cites W2804572516 @default.
- W4384661640 cites W2809115929 @default.
- W4384661640 cites W2914347154 @default.
- W4384661640 cites W2940112960 @default.
- W4384661640 cites W2946790573 @default.
- W4384661640 cites W2952821199 @default.
- W4384661640 cites W2992277605 @default.
- W4384661640 cites W3009229119 @default.
- W4384661640 cites W3014421663 @default.
- W4384661640 cites W3015143200 @default.
- W4384661640 cites W3019202954 @default.
- W4384661640 cites W3034234040 @default.
- W4384661640 cites W3103806837 @default.
- W4384661640 cites W3120609871 @default.
- W4384661640 cites W3186730541 @default.
- W4384661640 cites W3190329902 @default.
- W4384661640 cites W3195623637 @default.
- W4384661640 cites W3197823962 @default.
- W4384661640 cites W3200228454 @default.
- W4384661640 cites W3201653561 @default.
- W4384661640 cites W3214956837 @default.
- W4384661640 cites W4225276590 @default.
- W4384661640 cites W4290831124 @default.
- W4384661640 doi "https://doi.org/10.1021/acs.jafc.3c02671" @default.
- W4384661640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37463492" @default.
- W4384661640 hasPublicationYear "2023" @default.
- W4384661640 type Work @default.
- W4384661640 citedByCount "0" @default.
- W4384661640 crossrefType "journal-article" @default.
- W4384661640 hasAuthorship W4384661640A5010607811 @default.
- W4384661640 hasAuthorship W4384661640A5015996920 @default.
- W4384661640 hasAuthorship W4384661640A5027018165 @default.
- W4384661640 hasAuthorship W4384661640A5039989373 @default.
- W4384661640 hasAuthorship W4384661640A5054419328 @default.
- W4384661640 hasAuthorship W4384661640A5067447649 @default.
- W4384661640 hasAuthorship W4384661640A5087592842 @default.
- W4384661640 hasAuthorship W4384661640A5092492209 @default.
- W4384661640 hasConcept C104488531 @default.
- W4384661640 hasConcept C170493617 @default.
- W4384661640 hasConcept C181199279 @default.
- W4384661640 hasConcept C185592680 @default.
- W4384661640 hasConcept C202751555 @default.
- W4384661640 hasConcept C2777202666 @default.
- W4384661640 hasConcept C2777682936 @default.
- W4384661640 hasConcept C2777752497 @default.
- W4384661640 hasConcept C2778327999 @default.
- W4384661640 hasConcept C2778464347 @default.
- W4384661640 hasConcept C2781330172 @default.
- W4384661640 hasConcept C54355233 @default.
- W4384661640 hasConcept C55493867 @default.
- W4384661640 hasConcept C59822182 @default.
- W4384661640 hasConcept C61174792 @default.
- W4384661640 hasConcept C71240020 @default.
- W4384661640 hasConcept C74600772 @default.
- W4384661640 hasConcept C86803240 @default.
- W4384661640 hasConcept C96529984 @default.
- W4384661640 hasConcept C98274493 @default.
- W4384661640 hasConceptScore W4384661640C104488531 @default.
- W4384661640 hasConceptScore W4384661640C170493617 @default.
- W4384661640 hasConceptScore W4384661640C181199279 @default.
- W4384661640 hasConceptScore W4384661640C185592680 @default.
- W4384661640 hasConceptScore W4384661640C202751555 @default.
- W4384661640 hasConceptScore W4384661640C2777202666 @default.
- W4384661640 hasConceptScore W4384661640C2777682936 @default.
- W4384661640 hasConceptScore W4384661640C2777752497 @default.
- W4384661640 hasConceptScore W4384661640C2778327999 @default.
- W4384661640 hasConceptScore W4384661640C2778464347 @default.
- W4384661640 hasConceptScore W4384661640C2781330172 @default.
- W4384661640 hasConceptScore W4384661640C54355233 @default.
- W4384661640 hasConceptScore W4384661640C55493867 @default.
- W4384661640 hasConceptScore W4384661640C59822182 @default.
- W4384661640 hasConceptScore W4384661640C61174792 @default.
- W4384661640 hasConceptScore W4384661640C71240020 @default.
- W4384661640 hasConceptScore W4384661640C74600772 @default.
- W4384661640 hasConceptScore W4384661640C86803240 @default.
- W4384661640 hasConceptScore W4384661640C96529984 @default.
- W4384661640 hasConceptScore W4384661640C98274493 @default.