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- W4384662952 endingPage "2405" @default.
- W4384662952 startingPage "2395" @default.
- W4384662952 abstract "Abstract Critically ill patients have increased variability in beta-lactam antibiotic (beta-lactam) exposure due to alterations in their volume of distribution and elimination. Therapeutic drug monitoring (TDM) of beta-lactams, as a dose optimization and individualization tool, has been recommended to overcome this variability in exposure. Despite its potential benefit, only a few centres worldwide perform beta-lactam TDM. An important reason for the low uptake is that the evidence for clinical benefits of beta-lactam TDM is not well established. TDM also requires the availability of specific infrastructure, knowledge and expertise. Observational studies and systematic reviews have demonstrated that TDM leads to an improvement in achieving target concentrations, a reduction in potentially toxic concentrations and improvement of clinical and microbiological outcomes. However, a small number of randomized controlled trials have not shown a mortality benefit. Opportunities for improved study design are apparent, as existing studies are limited by their inclusion of heterogeneous patient populations, including patients that may not even have infection, small sample size, variability in the types of beta-lactams included, infections caused by highly susceptible bacteria, and varied sampling, analytical and dosing algorithm methods. Here we review the fundamentals of beta-lactam TDM in critically ill patients, the existing clinical evidence and the practical aspects involved in beta-lactam TDM implementation." @default.
- W4384662952 created "2023-07-20" @default.
- W4384662952 creator A5004410393 @default.
- W4384662952 creator A5027455882 @default.
- W4384662952 creator A5051292794 @default.
- W4384662952 creator A5087023094 @default.
- W4384662952 date "2023-07-19" @default.
- W4384662952 modified "2023-10-14" @default.
- W4384662952 title "The clinical application of beta-lactam antibiotic therapeutic drug monitoring in the critical care setting" @default.
- W4384662952 cites W1867125196 @default.
- W4384662952 cites W1899209738 @default.
- W4384662952 cites W1949467400 @default.
- W4384662952 cites W1966741177 @default.
- W4384662952 cites W1968944814 @default.
- W4384662952 cites W1971624521 @default.
- W4384662952 cites W1982910325 @default.
- W4384662952 cites W1985435644 @default.
- W4384662952 cites W1992820454 @default.
- W4384662952 cites W1993637608 @default.
- W4384662952 cites W1993645909 @default.
- W4384662952 cites W1998344084 @default.
- W4384662952 cites W2027548739 @default.
- W4384662952 cites W2044526347 @default.
- W4384662952 cites W2047032202 @default.
- W4384662952 cites W2051007415 @default.
- W4384662952 cites W2057939341 @default.
- W4384662952 cites W2059412778 @default.
- W4384662952 cites W2062495428 @default.
- W4384662952 cites W2067912729 @default.
- W4384662952 cites W2068236756 @default.
- W4384662952 cites W2079691262 @default.
- W4384662952 cites W2080374429 @default.
- W4384662952 cites W2082321986 @default.
- W4384662952 cites W2085150747 @default.
- W4384662952 cites W2089600008 @default.
- W4384662952 cites W2101416655 @default.
- W4384662952 cites W2102663241 @default.
- W4384662952 cites W2105689903 @default.
- W4384662952 cites W2111805706 @default.
- W4384662952 cites W2112401566 @default.
- W4384662952 cites W2113177846 @default.
- W4384662952 cites W2113717321 @default.
- W4384662952 cites W2121189212 @default.
- W4384662952 cites W2133916602 @default.
- W4384662952 cites W2139814250 @default.
- W4384662952 cites W2141655637 @default.
- W4384662952 cites W2142365884 @default.
- W4384662952 cites W2144045506 @default.
- W4384662952 cites W2153641174 @default.
- W4384662952 cites W2153655781 @default.
- W4384662952 cites W2165839757 @default.
- W4384662952 cites W2167638718 @default.
- W4384662952 cites W2286156236 @default.
- W4384662952 cites W2305806245 @default.
- W4384662952 cites W2342390979 @default.
- W4384662952 cites W2416696399 @default.
- W4384662952 cites W2416809297 @default.
- W4384662952 cites W2460245878 @default.
- W4384662952 cites W2547781899 @default.
- W4384662952 cites W2560397278 @default.
- W4384662952 cites W2576933161 @default.
- W4384662952 cites W2584388311 @default.
- W4384662952 cites W2594110291 @default.
- W4384662952 cites W2735133396 @default.
- W4384662952 cites W2735505232 @default.
- W4384662952 cites W2770288655 @default.
- W4384662952 cites W2770585743 @default.
- W4384662952 cites W2771362836 @default.
- W4384662952 cites W2777633015 @default.
- W4384662952 cites W2791962771 @default.
- W4384662952 cites W2886772901 @default.
- W4384662952 cites W2887835365 @default.
- W4384662952 cites W2889613240 @default.
- W4384662952 cites W2889630471 @default.
- W4384662952 cites W2895593384 @default.
- W4384662952 cites W2915964033 @default.
- W4384662952 cites W2922803436 @default.
- W4384662952 cites W2923535117 @default.
- W4384662952 cites W2942319426 @default.
- W4384662952 cites W2952041617 @default.
- W4384662952 cites W2953583576 @default.
- W4384662952 cites W2957691104 @default.
- W4384662952 cites W2963222371 @default.
- W4384662952 cites W2972401648 @default.
- W4384662952 cites W2977600010 @default.
- W4384662952 cites W2977924451 @default.
- W4384662952 cites W2982416482 @default.
- W4384662952 cites W3006785449 @default.
- W4384662952 cites W3012161191 @default.
- W4384662952 cites W3015167435 @default.
- W4384662952 cites W3021307263 @default.
- W4384662952 cites W3022327571 @default.
- W4384662952 cites W3039071397 @default.
- W4384662952 cites W3041883222 @default.
- W4384662952 cites W3049761879 @default.
- W4384662952 cites W3086564993 @default.
- W4384662952 cites W3092173712 @default.
- W4384662952 cites W3094543155 @default.