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• W4384663443 abstract "Abstract Daboxin P, reported earlier from the venom of Daboia russellii , disturbs the blood coagulation cascade by targeting factor X and factor Xa. The present study exhibits that Daboxin P also inhibits platelet aggregation induced by various agonists. The thrombin‐induced platelet aggregation was inhibited maximum whereas inhibition of collagen‐induced platelet aggregation was found to be 50% and no inhibition of adenosine diphosphate (ADP) and arachidonic acid‐induced aggregation was observed. Daboxin P dose‐dependently inhibited the thrombin‐induced platelet aggregation with Anti‐Aggregation 50 (AD 50 ) dose of 55.166 nM and also reduced the thrombin‐mediated calcium influx. In‐silico interaction studies suggested that Daboxin P binds to thrombin and blocks its interaction with its receptor on the platelet surface. Quenching of thrombin's emission spectrum by Daboxin P and electrophoretic profiles of pull‐down assay further reveals the binding between Daboxin P and thrombin. Thus, the present study demonstrates that Daboxin P inhibits thrombin‐induced platelet aggregation by binding to thrombin." @default.
• W4384663443 created "2023-07-20" @default.
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• W4384663443 date "2023-07-19" @default.
• W4384663443 modified "2023-09-24" @default.
• W4384663443 title "Daboxin P, a phospholipase A₂ of Indian <i>Daboia russelii</i> venom, modulates thrombin‐mediated platelet aggregation" @default.
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• W4384663443 doi "https://doi.org/10.1002/jbt.23476" @default.
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• W4384663443 hasPublicationYear "2023" @default.
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