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• W4384664005 abstract "Abstract Introduction Iodine and FDG uptakes have been established as methods to define the biological properties of thyroid cancer. As various cells in the tumor microenvironment (TME) affect tumor metabolism, we investigated the association between glucose metabolism in thyroid cancer and the TME using transcriptomic analyses. Methods We used F‐18 FDG PET and RNA sequencing data of thyroid cancer to find associations between TME cell types and glucose metabolism. In addition, publicly available single‐cell RNA sequencing data of papillary thyroid cancer was used to investigate glucose metabolism in cell types of the TME. The correlations between the FDG uptake and biological properties of the TME, including glucose metabolism and tumor differentiation score (TDS) were evaluated. Estimation of the proportions of immune and cancer cells (EPIC) was performed. The biological properties of each cell type were also assessed in the single‐cell RNA sequencing data. Results FDG uptake showed a positive correlation with the enrichment score of macrophages and glycolysis activity. In single‐cell RNA sequencing, immune cells had both high glucose transporters (GLUTs) and glycolysis signatures, while thyrocytes including cancer cells showed relatively low GLUTs and glycolysis signatures, suggesting that FDG uptake mainly occurred in immune cells of the TME. Moreover, the high GLUTs of myeloid cells were negatively associated with TDS. Conclusions Our findings suggest that thyroid cancer with high FDG uptake can be mediated by enriched immune cells of the TME. We suggest that FDG uptake in thyroid cancer could be a marker for the immune‐rich type and provide clinical implications for treatment stratification." @default.
• W4384664005 created "2023-07-20" @default.
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• W4384664005 date "2023-07-19" @default.
• W4384664005 modified "2023-10-17" @default.
• W4384664005 title "<scp>FDG</scp> uptake reflects an immune‐enriched subtype of thyroid cancer: Clinical implications of imaging‐based molecular characterization" @default.
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• W4384664005 doi "https://doi.org/10.1002/cam4.6350" @default.
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