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- W4384664034 abstract "A formal total synthesis of ecteinascidin 743 and lurbinectedin is achieved. Key features involve a Pictet-Spengler cyclization coupling of the tetrahydroisoquinoline and phenylalaninol moieties prepared by a common route with high yield and selectivity, a Parikh-Doering oxidation with good chemoselectivity and functionality tolerance, and a light-mediated A-ring elaboration of pentacyclic methoxyquinone substrates. By the approach, the known advanced intermediate (4-step conversion to Et-743) can be obtained conveniently in 21 total steps from N-Cbz-l-tyrosine." @default.
- W4384664034 created "2023-07-20" @default.
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- W4384664034 date "2023-07-18" @default.
- W4384664034 modified "2023-10-16" @default.
- W4384664034 title "Formal Synthesis of Ecteinascidin 743 from <i>N</i>-Cbz-<scp>l</scp>-tyrosine" @default.
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- W4384664034 doi "https://doi.org/10.1021/acs.joc.3c00931" @default.
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